CAS Number119-84-6
SynonymsDihydrocoumarin; MFCD00006881; 2-Chromanone; EINECS 204-354-9; 3,4-Dihydro-1-benzopyran-2-one,Benzodihydropyrone,Hydrocou; 3,4-dihydrochromen-2-one; 3,4-Dihydrocoumarin; Hydrocoumarin; chroman-2-one
Molecular FormulaC9H8O2
Molecular Weight148.16
Purity99%
Density1.2±0.1 g/cm3
Boiling Point272 °C (lit.)
Melting Point24-25 °C (lit.)
Appearanceliquid
EINECS204-354-9
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 119-84-6 |
| Catalog No. | 2A-9019056 |
| Chinese Name | 二氢香豆素 |
| Synonyms | Dihydrocoumarin; MFCD00006881; 2-Chromanone; EINECS 204-354-9; 3,4-Dihydro-1-benzopyran-2-one,Benzodihydropyrone,Hydrocou; 3,4-dihydrochromen-2-one; 3,4-Dihydrocoumarin; Hydrocoumarin; chroman-2-one |
| Molecular Formula | C9H8O2 |
| Molecular Weight | 148.16 |
| Purity | 99 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 272 °C (lit.) |
| Melting Point | 24-25 °C (lit.) |
| Appearance | liquid |
| Water Solubility | insoluble |
| Storage Condition | Keep it airtight and shielded from light, and stor |
| Application | Dihydrocumarin is a compound found in Melilotus officinalis. Dihydrocumarin is a yeast Sir2p inhibitor. Dihydrocumarin also inhibits human SIRT1 and SIRT2 with IC 50 of 208 μM and 295 μM, respectively |
| EINECS | 204-354-9 |
| HTC | 29322980 |
| PubChem ID | 24893333 |
| MDL Number | MFCD00006881 |
| SMILES | O=C1CCc2ccccc2O1 |
| InChI | 1S/C9H8O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-4H,5-6H2 |
| InChI Key | VMUXSMXIQBNMGZ-UHFFFAOYSA-N |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| Hazard Symbols | Transport |
| Bioactivity | Dihydrocoumarin is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin also inhibits human SIRT1 and SIRT2 with IC50s of 208 μM and 295 μM, respectively[1]. Related Catalog Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin Signaling Pathways >> Epigenetics >> Sirtuin Natural Products >> Phenylpropanoids Research Areas >> Cancer Target hSIRT1:208 μM (IC50) hSIRT2:295 μM (IC50) In Vitro Dihydrocoumarin induces a concentration-dependent inhibition of SIRT1 (IC50 of 208 μM) in an in vitro enzymatic assay. A decrease in SIRT1 deacetylase activity is observed even at micromolar doses (85±5.8 and 73±13.7% activity at 1.6 μM and 8 μM, respectively). The microtubule SIRT2 deacetylase is also inhibited with a similar dose dependency (IC50 of 295 μM)[1]. Dihydrocoumarin (1-5 mM) increases cytotoxicity in the TK6 cell line in a dose-dependent manner following a 24-h exposure. Dihydrocoumarin (1-5 mM) increases apoptosis in a dose-dependent manner in the TK6 cell line at the 6-h time point. A 5-mM dose of Dihydrocoumarin increases apoptosis at the 6-h time point in the TK6 cell line[1]. Dihydrocoumarin (1-5 mM) increases p53 lysine 373 and 382 acetylation in a dose-dependent manner in the TK6 cell line following a 24-h exposure period[1]. References [1]. Olaharski AJ, et al. The flavoring agent Dihydrocoumarin reverses epigenetic silencing and inhibits sirtuindeacetylases. PLoS Genet. 2005 Dec;1(6):e77. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 272.0±15.0 °C at 760 mmHg Melting Point 24-25 °C(lit.) Molecular Formula C9H8O2 Molecular Weight 148.159 Flash Point 108.4±17.8 °C Exact Mass 148.052429 PSA 26.30000 LogP 1.80 Vapour Pressure 0.0±0.6 mmHg at 25°C Index of Refraction 1.562 InChIKey VMUXSMXIQBNMGZ-UHFFFAOYSA-N SMILES O=C1CCc2ccccc2O1 Water Solubility insoluble |
| Use of | Dihydrocoumarin is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin also inhibits human SIRT1 and SIRT2 with IC50s of 208 μM and 295 μM, respectively[1]. Properties Articles22 Name 3,4-dihydrocoumarin Synonym More Synonyms Dihydrocoumarin Biological Activity Description Dihydrocoumarin is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin also inhibits human SIRT1 and SIRT2 with IC50s of 208 μM and 295 μM, respectively[1]. Related Catalog Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin Signaling Pathways >> Epigenetics >> Sirtuin Natural Products >> Phenylpropanoids Research Areas >> Cancer hSIRT1:208 μM (IC50) hSIRT2:295 μM (IC50) References [1]. Olaharski AJ, et al. The flavoring agent Dihydrocoumarin reverses epigenetic silencing and inhibits sirtuindeacetylases. PLoS Genet. 2005 Dec;1(6):e77. Chemical & Physical Properties Molecular Formula C9H8O2 Exact Mass 148.052429 PSA 26.30000 Index of Refraction 1.562 InChIKey VMUXSMXIQBNMGZ-UHFFFAOYSA-N Water Solubility insoluble |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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