EN
0
Home > Products > Specialty & Industrial Chemicals > Specialty Chemicals > N-PHENYL-4-[[(PHENYLAMINO)THIOXOMETHYL]AMINO]-BENZENESULFONAMIDE
N-PHENYL-4-[[(PHENYLAMINO)THIOXOMETHYL]AMINO]-BENZENESULFONAMIDE structure, CAS 245342-14-7

N-PHENYL-4-[[(PHENYLAMINO)THIOXOMETHYL]AMINO]-BENZENESULFONAMIDE

CAS Number245342-14-7

SynonymsLED209 hydrate; N-Phenyl-4-(3-phenylthioureido)benzenesulfonamide; N-Phenyl-4-[(phenylcarbamothioyl)amino]benzenesulfonamide; N-phenyl-4-[[(phenylamino)thioxomethyl]amino]benzenesulfonamide hydrate; LED209

Molecular FormulaC19H17N3O2S2

Molecular Weight383.487

Purity

Density1.4±0.1 g/cm3

Boiling Point549.4±60.0 °C at 760 mmHg

Melting Point

Flash Point

Appearance

EINECS

MSDSChineseEnglish

Symboltransportation

Signal WordWarning

Cat. No.: 2A-2187160 Purity:
Change View

Please Login or Create an Account to: See VlP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

Inquiry

Quality Control of [ 245342-14-7 ] SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number245342-14-7
Catalog No.2A-2187160
Chinese NameN-苯基-4-(3-苯基硫代脲基)苯磺酰胺
SynonymsLED209 hydrate; N-Phenyl-4-(3-phenylthioureido)benzenesulfonamide; N-Phenyl-4-[(phenylcarbamothioyl)amino]benzenesulfonamide; N-phenyl-4-[[(phenylamino)thioxomethyl]amino]benzenesulfonamide hydrate; LED209
Molecular FormulaC19H17N3O2S2
Molecular Weight383.487
Density1.4±0.1 g/cm3
Boiling Point549.4±60.0 °C at 760 mmHg
Storage Condition2-8℃
ApplicationLED209 is a potent small molecule inhibitor of the bacterial receptor QseC, a potent prodrug, and highly selective for QseC.
PubChem ID4567477
SMILESO=S(=O)(Nc1ccccc1)c1ccc(NC(=S)Nc2ccccc2)cc1
InChIInChI=1S/C19H17N3O2S2/c23-26(24,22-17-9-5-2-6-10-17)18-13-11-16(12-14-18)21-19(25)20-15-7-3-1-4-8-15/h1-14,22H,(H2,20,21,25)
InChI KeyHNDRSTUKPCLQLT-UHFFFAOYSA-N
Hazard Symbolstransportation
BioactivityLED209 is a potent small molecule inhibitor of bacterial receptor QseC, is a potent prodrug that is highly selective for QseC. Target: AntibacterialLED209 has desirable pharmacokinetics and does not present toxicity in vitro and in rodents. This is a unique antivirulence approach, with a proven broad-spectrum activity against multiple Gram-negative pathogens that cause mammalian infections.The LED209 QseC inhibitor has a unique mode of action by acting as a prodrug scaffold to deliver a warhead that allosterically modifies QseC, impeding virulence in several Gram-negative pathogens.[1] LED209 is QseC sensor kinase inhibitor , as a potential lead compound to combat infections with Legionella or Mycobacterium spp. [2] LED209 inhibits the binding of signals to QseC, preventing its autophosphorylation and consequently inhibiting QseC-mediated activation of virulence gene expression. LED209 inhibits EHEC virulence traits in vitro. LED209 markedly inhibits the virulence of several pathogens in animals. Inhibition of signaling offers a strategy for the development of broad-spectrum antimicrobial drugs. [3] Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [1]. Curtis MM, et al. QseC inhibitors as an antivirulence approach for Gram-negative pathogens. MBio. 2014 Nov 11;5(6):e02165. [2]. Harrison CF, et al. Adrenergic antagonists restrict replication of Legionella. Microbiology. 2015 Jul;161(7):1392-406. [3]. Rasko DA, et al. Targeting QseC signaling and virulence for antibiotic development. Science. 2008 Aug 22;321(5892):1078-80. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 549.4±60.0 °C at 760 mmHg Molecular Formula C19H17N3O2S2 Molecular Weight 383.487 Flash Point 286.1±32.9 °C Exact Mass 383.076202 PSA 110.70000 LogP 3.40 Vapour Pressure 0.0±1.5 mmHg at 25°C Index of Refraction 1.741 InChIKey HNDRSTUKPCLQLT-UHFFFAOYSA-N SMILES O=S(=O)(Nc1ccccc1)c1ccc(NC(=S)Nc2ccccc2)cc1 Storage condition 2-8℃
Use ofProperties Name 1-phenyl-3-[4-(phenylsulfamoyl)phenyl]thiourea Synonym More Synonyms LED209 Biological Activity Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [1]. Curtis MM, et al. QseC inhibitors as an antivirulence approach for Gram-negative pathogens. MBio. 2014 Nov 11;5(6):e02165. [2]. Harrison CF, et al. Adrenergic antagonists restrict replication of Legionella. Microbiology. 2015 Jul;161(7):1392-406. [3]. Rasko DA, et al. Targeting QseC signaling and virulence for antibiotic development. Science. 2008 Aug 22;321(5892):1078-80. Chemical & Physical Properties Molecular Formula C19H17N3O2S2 Exact Mass 383.076202 PSA 110.70000 Index of Refraction 1.741 InChIKey HNDRSTUKPCLQLT-UHFFFAOYSA-N Storage condition 2-8℃
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available
Related Products in Specialty Chemicals
IDX-1841036915-08-82A-2187152
Ortataxel1613081-64-32A-2187154
SB9200942123-43-52A-2187156
MK 5172 sodiuM salt1425038-27-22A-2187157
XENON DIFLUORIDE13709-36-92A-1187158
Difluoxacin hydrochloride91296-86-52A-2187161
PHYTOL150-86-72A-2187162
Lasalocid25999-31-92A-2187163
Dextrorotation nimorazole phosphate ester1124347-33-62A-2187164
squalamine148717-90-22A-2187165
Browse all Specialty Chemicals products »
Contact Us

Phone:

630-322-8886

630-322-8887

Email:

[email protected]

Office Locations:

Chicago, IL, USA

San Francisco, CA, USA