CAS Number25387-67-1
Synonymscamptothecinsodium; camptothecin,sodiumsalt; 21,22-Secocamptothecin-21-oic acid,monosodium salt 20(S)-camptothecin sodium salt; Fda 1660; 21,22-secocamptothecin-21-oicacid,monosodiumsalt; 20(s)-camptothecinsodiumsalt; camptothecin Na; camptothecinesodium; CaMphotecin sodiuM
Molecular FormulaC20H17N2NaO5
Molecular Weight388.34900
Boiling Point777.3ºC at 760 mmHg
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 25387-67-1 |
| Catalog No. | 2A-3185491 |
| Chinese Name | 喜树碱钠 |
| Synonyms | camptothecinsodium; camptothecin,sodiumsalt; 21,22-Secocamptothecin-21-oic acid,monosodium salt 20(S)-camptothecin sodium salt; Fda 1660; 21,22-secocamptothecin-21-oicacid,monosodiumsalt; 20(s)-camptothecinsodiumsalt; camptothecin Na; camptothecinesodium; CaMphotecin sodiuM |
| Molecular Formula | C20H17N2NaO5 |
| Molecular Weight | 388.34900 |
| Boiling Point | 777.3ºC at 760 mmHg |
| Storage Condition | The warehouse is ventilated and dry at low tempera |
| Application | Sodium Camptothecin is a plant alkaloid with antitumor activity. Sodium Camptothecin is a reversible inhibitor of RNA synthesis. Sodium Camptothecin is a potent inhibitor of adenovirus replication. So |
| HTC | 2942000000 |
| PubChem ID | 22423917 |
| SMILES | CCC(O)(C(=O)O)c1cc2n(c(=O)c1CO)Cc1cc3ccccc3nc1-2.[Na] |
| InChI | InChI=1S/C20H18N2O5.Na.H/c1-2-20(27,19(25)26)14-8-16-17-12(9-22(16)18(24)13(14)10-23)7-11-5-3-4-6-15(11)21-17;;/h3-8,23,27H,2,9-10H2,1H3,(H,25,26);;/q;+1;-1 |
| InChI Key | PBJLMBQVBUDNJL-BDQAORGHSA-N |
| Use of | Sodium Camptothecin is a plant alkaloid, with antitumor activity. Sodium Camptothecin is a reversible inhibitor of RNA synthesis. Sodium Camptothecin is an effective inhibitor of adenovirus replication. Sodium Camptothecin inhibits DNA synthesis and, intracellularly, causes breaks in preformed viral DNA[1][2]. Properties Name sodium camptothecin Synonym More Synonyms 20(S)-Camptothecin sodium salt Biological Activity Description Sodium Camptothecin is a plant alkaloid, with antitumor activity. Sodium Camptothecin is a reversible inhibitor of RNA synthesis. Sodium Camptothecin is an effective inhibitor of adenovirus replication. Sodium Camptothecin inhibits DNA synthesis and, intracellularly, causes breaks in preformed viral DNA[1][2]. Related Catalog Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis References [1]. R S Wu, et al. Ribosome formation is blocked by camptothecin, a reversible inhibitor of RNA synthesis. Proc Natl Acad Sci U S A. 1971 Dec;68(12):3009-14. [2]. M S Horwitz, et al. Camptothecin: mechanism of inhibition of adenovirus formation. Virology. 1972 Jun;48(3):690-8 Chemical & Physical Properties Molecular Formula C20H17N2NaO5 Exact Mass 388.10400 PSA 115.48000 LogP 0.26500 InChIKey PBJLMBQVBUDNJL-BDQAORGHSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Camptothecin, sodium salt CAS REGISTRY NUMBER : 25387-67-1 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C20-H18-N2-O5.Na MOLECULAR WEIGHT : WISWESSER LINE NOTATION : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : DOSE/DURATION : 2500 ug/kg/7D-I TOXIC EFFECTS : Blood - leukopenia Blood - thrombocytopenia Blood - changes in cell count (unspecified) REFERENCE : CCROBU Cancer Chemotherapy Reports, Part 1. (Washington, DC) V.52(6)-59, 1968-75. For publisher information, see CTRRDO. Volume(issue)/page/year: 56,515,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year: 9,1,1973 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : GTKRDX Gan to Kagaku Ryoho. Cancer and Chemotherapy. (1-8-9 Yaesu, Chuo-ku, Tokyo 103, Japan) V.1- 1974- Volume(issue)/page/year: 14,850,1987 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year: 9,1,1973 Safety Information Hazard Codes T+ HS Code 2942000000 Synthetic Route Total: 1 Page Campathecin CAS#:7689-03-4 20(S)-Camptothe... CAS#:25387-67-1 Literature: MediGene Oncology GmbH Patent: EP1547582 A1, 2005 ; Location in patent: Page/Page column 10 ; Precursor & DownStream Precursor 1 CAS#:7689-03-4 Campathecin DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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