CAS Number108-59-8
Synonymsdimethyl propanedioate; Propanedioic acid, dimethyl ester; Dimethyl malonate; MFCD00008460; Malonic acid dimethyl ester; methyl malonate; EINECS 203-597-8; Malonic acid, dimethyl ester
Molecular FormulaCH2(COOCH3)2
Molecular Weight132.11
Purity98%
Density1.1±0.1 g/cm3
Boiling Point180-181 °C (lit.)
Melting Point−62 °C (lit.)
Appearanceliquid
EINECS203-597-8
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 108-59-8 |
| Catalog No. | 2A-9018629 |
| Chinese Name | 丙二酸二甲酯 |
| Synonyms | dimethyl propanedioate; Propanedioic acid, dimethyl ester; Dimethyl malonate; MFCD00008460; Malonic acid dimethyl ester; methyl malonate; EINECS 203-597-8; Malonic acid, dimethyl ester |
| Molecular Formula | CH2(COOCH3)2 |
| Molecular Weight | 132.11 |
| Purity | 98 |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 180-181 °C (lit.) |
| Melting Point | −62 °C (lit.) |
| Appearance | liquid |
| Water Solubility | negligible |
| Storage Condition | Store in a cool, ventilated warehouse. Keep away f |
| Application | Dimethyl malonate is a competitive inhibitor of succinate dehydrogenase (SDH). Dimethylmalonate crosses the blood-brain barrier and is hydrolyzed to malonic acid. Dimethylmalonate reduces neuronal apo |
| EINECS | 203-597-8 |
| HTC | 29171910 |
| PubChem ID | 24848281 |
| MDL Number | MFCD00008460 |
| SMILES | COC(=O)CC(=O)OC |
| InChI | 1S/C5H8O4/c1-8-4(6)3-5(7)9-2/h3H2,1-2H3 |
| InChI Key | BEPAFCGSDWSTEL-UHFFFAOYSA-N |
| Beilstein/REAXYS | 774261 |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| MSDS | msds/18629_1_108_59_8.pdf |
| Bioactivity | Dimethyl malonate is a competitive inhibitor of succinate dehydrogenase (SDH). Dimethyl malonate is able to cross the blood-brain barrier and hydrolyse to malonate. Dimethyl malonate reduces neuronal apoptosis[1]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Neurological Disease In Vivo Dimethyl malonate (6 mg/kg/min; intravenous infusion; 51 min) promotes return of spontaneous circulation (ROSC) and neurological performance in rats after cardiac arrest[1]. Animal Model: Sprague-Dawley male rats, cardiac arrest model[1] Dosage: 6 mg/kg/min Administration: Intravenous infusion, 51 min Result: Improved ROSC after CA. Prevented the decline in neurological function and inhibited the apoptosis of hippocampal neurons at day 3 after CPR. Inhibited caspase-3 cleavage and increased HIF-1α expression at day 3 after CPR. Decreased the level of oxidative stress at day 3 after CPR. Inhibited excessive hyperpolarization of MMP and restrained the leakage of cytochrome C after 45 min reperfusion. References [1]. Xu J, et al. Inhibiting Succinate Dehydrogenase by Dimethyl Malonate Alleviates Brain Damage in a Rat Model of Cardiac Arrest. Neuroscience. 2018 Nov 21;393:24-32. Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 177.1±8.0 °C at 760 mmHg Melting Point −62 °C(lit.) Molecular Formula C5H8O4 Molecular Weight 132.115 Flash Point 90.0±0.0 °C Exact Mass 132.042252 PSA 52.60000 LogP -0.36 Vapour density >1 (vs air) Vapour Pressure 1.1±0.3 mmHg at 25°C Index of Refraction 1.402 InChIKey BEPAFCGSDWSTEL-UHFFFAOYSA-N SMILES COC(=O)CC(=O)OC Stability Stable. Incompatible with strong oxidizing agents. Flammable. Water Solubility negligible |
| Use of | Dimethyl malonate is a competitive inhibitor of succinate dehydrogenase (SDH). Dimethyl malonate is able to cross the blood-brain barrier and hydrolyse to malonate. Dimethyl malonate reduces neuronal apoptosis[1]. Properties Articles28 Name Dimethyl malonate Synonym More Synonyms Dimethyl malonate Biological Activity Description Dimethyl malonate is a competitive inhibitor of succinate dehydrogenase (SDH). Dimethyl malonate is able to cross the blood-brain barrier and hydrolyse to malonate. Dimethyl malonate reduces neuronal apoptosis[1]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Neurological Disease References [1]. Xu J, et al. Inhibiting Succinate Dehydrogenase by Dimethyl Malonate Alleviates Brain Damage in a Rat Model of Cardiac Arrest. Neuroscience. 2018 Nov 21;393:24-32. Chemical & Physical Properties Molecular Formula C5H8O4 Exact Mass 132.042252 PSA 52.60000 LogP -0.36 Vapour density >1 (vs air) Index of Refraction 1.402 InChIKey BEPAFCGSDWSTEL-UHFFFAOYSA-N SMILES COC(=O)CC(=O)OC Stability Stable. Incompatible with strong oxidizing agents. Flammable. Water Solubility negligible |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 0.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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