CAS Number34368-04-2
Synonyms4-[2-[[3-(4-Hydroxyphenyl)-1-methylpropyl]amino]ethyl]-1,2-benzenediol; DOBUTAMINE HCL; 1,2-Benzenediol,4-[2-[[3-(4-hydroxyphenyl)-1-methylpropyl]amino]ethyl]-,(+-); (±)-dobutamine; DOBUTAMINE HYDROCHLORIDE; 4-[2-[4-(4-HYDROXYPHENYL)BUTAN-2-YLAMINO]ETHYL]BENZENE-1,2-DIOL
Molecular FormulaC18H23NO3
Molecular Weight337.84
Purity98.00%
Density1.189g/cm3
Boiling Point527.7ºC at 760mmHg
AppearanceWhite or off-white crystalline powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 34368-04-2 |
| Catalog No. | 2A-1182828 |
| Chinese Name | 多巴酚丁胺 |
| Synonyms | 4-[2-[[3-(4-Hydroxyphenyl)-1-methylpropyl]amino]ethyl]-1,2-benzenediol; DOBUTAMINE HCL; 1,2-Benzenediol,4-[2-[[3-(4-hydroxyphenyl)-1-methylpropyl]amino]ethyl]-,(+-); (±)-dobutamine; DOBUTAMINE HYDROCHLORIDE; 4-[2-[4-(4-HYDROXYPHENYL)BUTAN-2-YLAMINO]ETHYL]BENZENE-1,2-DIOL |
| Molecular Formula | C18H23NO3 |
| Molecular Weight | 337.84 |
| Purity | 98.00 |
| Density | 1.189g/cm3 |
| Boiling Point | 527.7ºC at 760mmHg |
| Appearance | White or off-white crystalline powder |
| Storage Condition | 2-8°C |
| Application | Dobutamine is a synthetic catecholamine that acts on α1-AR, β1-AR and β2-AR (α1, β1 and β2 adrenergic receptors). Dobutamine is a selective β1-AR agonist with relatively weak activity at α1-AR and β2- |
| HTC | 2922509090 |
| PubChem ID | 329798764 |
| SMILES | CC(CCc1ccc(O)cc1)NCCc1ccc(O)c(O)c1 |
| InChI | InChI=1S/C18H23NO3/c1-13(2-3-14-4-7-16(20)8-5-14)19-11-10-15-6-9-17(21)18(22)12-15/h4-9,12-13,19-22H,2-3,10-11H2,1H3 |
| InChI Key | JRWZLRBJNMZMFE-UHFFFAOYSA-N |
| Use of | Dobutamine is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine can increase cardiac output and correct hypoperfusion[1][2][3][4]. Properties Name dobutamine Synonym More Synonyms dobutamine Biological Activity Description Dobutamine is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine can increase cardiac output and correct hypoperfusion[1][2][3][4]. Related Catalog Research Areas >> Cardiovascular Disease Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor References [1]. Tuttle RR, et al. Dobutamine: development of a new catecholamine to selectively increase cardiac contractility. Circ Res. 1975 Jan;36(1):185-96. [2]. Vallet B, et al. Dobutamine: mechanisms of action and use in acute cardiovascular pathology. Ann Cardiol Angeiol (Paris). 1991 Jun;40(6):397-402. [3]. Tyrankiewicz U , et al. Characterization of the cardiac response to a low and high dose of dobutamine in the mouse model of dilated cardiomyopathy by MRI in vivo. J Magn Reson Imaging. 2013 Mar;37(3):669-77. [4]. Tibayan FA, et al. Dobutamine increases alveolar liquid clearance in ventilated rats by beta-2 receptor stimulation. Am J Respir Crit Care Med. 1997 Aug;156(2 Pt 1):438-44. Chemical & Physical Properties Molecular Formula C18H23NO3 Exact Mass 301.16800 PSA 72.72000 LogP 3.34770 InChIKey JRWZLRBJNMZMFE-UHFFFAOYSA-N Safety Information Hazard Codes Xn: Harmful; WGK Germany 3 HS Code 2922509090 Synthetic Route Total: 1 Page N-(3,4-dimethox... CAS#:61413-44-3 dobutamine CAS#:34368-04-2 3,4-Dimethoxyph... CAS#:120-20-7 anisylidene acetone CAS#:3815-30-3 dobutamine CAS#:34368-04-2 N-(3,4-dimethox... CAS#:61413-44-3 Literature: US3987200 A1, ; CAS#:1020073-90-8 dobutamine CAS#:34368-04-2 Precursor & DownStream Precursor 3 CAS#:61413-44-3 N-(3,4-dimethox... CAS#:120-20-7 3,4-Dimethoxyph... CAS#:3815-30-3 anisylidene acetone DownStream 0 |
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