CAS Number293754-55-9
SynonymsN-[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide; MFCD03412028; N-[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxy-2-propanyl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide; T0901317
Molecular FormulaC17H12F9NO3S
Molecular Weight481.33
Purity98.00%
Density1.5±0.1 g/cm3
Boiling Point470.5±55.0 °C at 760 mmHg
Melting Point116-122° C
Appearancesolid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 293754-55-9 |
| Catalog No. | 2A-1182751 |
| Chinese Name | N-(2,2,2-三氟乙基)-N-[4-[2,2,2-三氟-1-羟基-1-(三氟甲基)乙基]苯基]-苯磺酰胺 |
| Synonyms | N-[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide; MFCD03412028; N-[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxy-2-propanyl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide; T0901317 |
| Molecular Formula | C17H12F9NO3S |
| Molecular Weight | 481.33 |
| Purity | 98.00 |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 470.5±55.0 °C at 760 mmHg |
| Melting Point | 116-122° C |
| Appearance | solid |
| Storage Condition | Sealed in a cool, dry environment at -20 ºC |
| Application | T0901317 is a potent, selective LXR and FXR agonist with EC50 of 50 nM and 5 μM, respectively. |
| PubChem ID | 24900032 |
| SMILES | O=S(=O)(c1ccccc1)N(CC(F)(F)F)c1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1 |
| InChI | InChI=1S/C17H12F9NO3S/c18-14(19,20)10-27(31(29,30)13-4-2-1-3-5-13)12-8-6-11(7-9-12)15(28,16(21,22)23)17(24,25)26/h1-9,28H,10H2 |
| InChI Key | SGIWFELWJPNFDH-UHFFFAOYSA-N |
| Hazard Symbols | transportation |
| Bioactivity | T0901317 is a potent and selective agonist for LXR and FXR, with EC50s of 50 nM and 5 μM, respectively. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> FXR Signaling Pathways >> Metabolic Enzyme/Protease >> LXR Research Areas >> Cancer References [1]. Ding H et al. LXR agonist T0901317 upregulates thrombomodulin expression in glomerular endothelial cells by inhibition of nuclear factor?κB. Mol Med Rep. 2016 Jun;13(6):4888-96 [2]. Baranowski M et al. Insulin-sensitizing effect of LXR agonist T0901317 in high-fat fed rats is associated with restored muscle GLUT4 expression and insulin-stimulated AS160 phosphorylation. Cell Physiol Biochem. 2014;33(4):1047-5 Chemical & Physical Properties Density 1.5±0.1 g/cm3 Boiling Point 470.5±55.0 °C at 760 mmHg Melting Point 116-122° C Molecular Formula C17H12F9NO3S Molecular Weight 481.333 Flash Point 238.4±31.5 °C Exact Mass 481.039429 PSA 65.99000 LogP 4.82 Vapour Pressure 0.0±1.2 mmHg at 25°C Index of Refraction 1.491 InChIKey SGIWFELWJPNFDH-UHFFFAOYSA-N SMILES O=S(=O)(c1ccccc1)N(CC(F)(F)F)c1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1 Storage condition -20°C |
| Use of | T0901317 is a potent and selective agonist for LXR and FXR, with EC50s of 50 nM and 5 μM, respectively. Properties Articles11 Name N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide Synonym More Synonyms T0901317 Biological Activity Description T0901317 is a potent and selective agonist for LXR and FXR, with EC50s of 50 nM and 5 μM, respectively. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> FXR Signaling Pathways >> Metabolic Enzyme/Protease >> LXR Research Areas >> Cancer References [1]. Ding H et al. LXR agonist T0901317 upregulates thrombomodulin expression in glomerular endothelial cells by inhibition of nuclear factor?κB. Mol Med Rep. 2016 Jun;13(6):4888-96 [2]. Baranowski M et al. Insulin-sensitizing effect of LXR agonist T0901317 in high-fat fed rats is associated with restored muscle GLUT4 expression and insulin-stimulated AS160 phosphorylation. Cell Physiol Biochem. 2014;33(4):1047-5 Chemical & Physical Properties Molecular Formula C17H12F9NO3S Exact Mass 481.039429 PSA 65.99000 Index of Refraction 1.491 InChIKey SGIWFELWJPNFDH-UHFFFAOYSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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