CAS Number36141-82-9
SynonymsDiamfenetide; bis-[2-(4-acetylamino-phenoxy)-ethyl]-ether; diamphenethide; Coryphamin; Bis-[2-(4-acetylamino-phenoxy)-aethyl]-aether; Acemidophene; EINECS 252-886-5; Diamfenetidum [INN-Latin]; Diamfenetida [INN-Spanish]
Molecular FormulaC20H24N2O5
Molecular Weight372.41500
Density1.225g/cm3
Boiling Point661.8ºC at 760 mmHg
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 36141-82-9 |
| Catalog No. | 2A-2181327 |
| Chinese Name | 双胺酚醚 |
| Synonyms | Diamfenetide; bis-[2-(4-acetylamino-phenoxy)-ethyl]-ether; diamphenethide; Coryphamin; Bis-[2-(4-acetylamino-phenoxy)-aethyl]-aether; Acemidophene; EINECS 252-886-5; Diamfenetidum [INN-Latin]; Diamfenetida [INN-Spanish] |
| Molecular Formula | C20H24N2O5 |
| Molecular Weight | 372.41500 |
| Density | 1.225g/cm3 |
| Boiling Point | 661.8ºC at 760 mmHg |
| Application | Diamfenetide for in vitro studies of Fasciola hepatica infection. Diamfenetide causes irreversible paralysis in adult and juvenile Fasciola hepatica. |
| HTC | 2924299090 |
| PubChem ID | 145522 |
| SMILES | CC(=O)Nc1ccc(OCCOCCOc2ccc(NC(C)=O)cc2)cc1 |
| InChI | InChI=1S/C20H24N2O5/c1-15(23)21-17-3-7-19(8-4-17)26-13-11-25-12-14-27-20-9-5-18(6-10-20)22-16(2)24/h3-10H,11-14H2,1-2H3,(H,21,23)(H,22,24) |
| InChI Key | JNEZCZPNQCQCFK-UHFFFAOYSA-N |
| Hazard Symbols | transportation |
| Bioactivity | Diamfenetide is used for the study of Fasciola hepatica infections in vitro. Diamfenetide leads to irreversible paralysis in vitro of immature and adult Fasciola hepatica[1]. Related Catalog Research Areas >> Infection In Vitro Diamfenetide (10-100 μM; 1-3 hours) treatment leads a time/dose-dependent, irreversible paralysis that involves an increase in muscular tension and decrease in contraction amplitude in vitro of immature and adult Fasciola hepatica[1]. Diamfenetide (100 μM; 6-24 hours) increases products of glucose metabolism by adult Fasciola hepatica in vitro. And the metabolic effects of Diamfenetide on F. hepatica may be secondary to the initial effects on surface membranes[2]. References [1]. R S Rew, et al. Fasciola Hepatica: Effects of Diamfenetide Free Amine on in Vitro Physiology, Biochemistry, and Morphology. Exp Parasitol [2]. R S Rew, et al. Effects of Diamfenetide on Metabolic and Excretory Functions of Fasciola Hepatica in Vitro. Comp Biochem Physiol C Chemical & Physical Properties Density 1.225g/cm3 Boiling Point 661.8ºC at 760 mmHg Molecular Formula C20H24N2O5 Molecular Weight 372.41500 Flash Point 354.1ºC Exact Mass 372.16900 PSA 85.89000 LogP 3.22380 Index of Refraction 1.595 InChIKey JNEZCZPNQCQCFK-UHFFFAOYSA-N SMILES CC(=O)Nc1ccc(OCCOCCOc2ccc(NC(C)=O)cc2)cc1 |
| Use of | Diamfenetide is used for the study of Fasciola hepatica infections in vitro. Diamfenetide leads to irreversible paralysis in vitro of immature and adult Fasciola hepatica[1]. Properties Name N-[4-[2-[2-(4-acetamidophenoxy)ethoxy]ethoxy]phenyl]acetamide Synonym More Synonyms Diamfenetide Biological Activity Description Diamfenetide is used for the study of Fasciola hepatica infections in vitro. Diamfenetide leads to irreversible paralysis in vitro of immature and adult Fasciola hepatica[1]. Related Catalog Research Areas >> Infection In Vitro Diamfenetide (10-100 μM; 1-3 hours) treatment leads a time/dose-dependent, irreversible paralysis that involves an increase in muscular tension and decrease in contraction amplitude in vitro of immature and adult Fasciola hepatica[1]. Diamfenetide (100 μM; 6-24 hours) increases products of glucose metabolism by adult Fasciola hepatica in vitro. And the metabolic effects of Diamfenetide on F. hepatica may be secondary to the initial effects on surface membranes[2]. References [1]. R S Rew, et al. Fasciola Hepatica: Effects of Diamfenetide Free Amine on in Vitro Physiology, Biochemistry, and Morphology. Exp Parasitol [2]. R S Rew, et al. Effects of Diamfenetide on Metabolic and Excretory Functions of Fasciola Hepatica in Vitro. Comp Biochem Physiol C Chemical & Physical Properties Molecular Formula C20H24N2O5 Exact Mass 372.16900 PSA 85.89000 LogP 3.22380 Index of Refraction 1.595 InChIKey JNEZCZPNQCQCFK-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 99.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Danger Regulations: 3077 International Maritime Transport Danger Regulations: 3077 International Air Transport Danger Regulations: 3077 14.2 Names specified by the United Nations (UN) European land transport hazard regulations: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (N-(4-(2-(2-(4- (acetylamino)phenoxy)ethoxy)ethoxy)phenyl)acetamide) IMDG Code: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (N-(4-(2-(2-(4- (acetylamino)phenoxy)ethoxy)ethoxy)phenyl)acetamide) International air transport hazard regulations: Environmentally hazardous substance, solid, n.o.s. (N-(4-(2-(2-(4- (acetylamino)phenoxy)ethoxy)ethoxy)phenyl)acetamide) 14.3 Transport hazard categories European land transport Dangerous Regulations: 9 International sea transport Dangerous Regulations: 9 International air transport Dangerous Regulations: 9 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Dangerous Regulations: Yes International Maritime Transport Dangerous Regulations Maritime Pollutants: Yes International Air Transport Dangerous Regulations: Yes 14.6 Special reminder to users further information Dangerous goods are individually packaged, with liquids exceeding 5 liters or solids exceeding 5 kilograms. The outer packaging of each independent package and the combined independent inner package must have EHS on it. Identification (according to European ADR Regulation 2.2.9.1.10, IMDG Regulation 2.10.3), |
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