CAS Number37860-51-8
SynonymsTETRAETHYLENE GLYCOL DI-P-TOSYLATE; Tetraethylene Glycol Bis(p-toluenesulfonate); Bis[2-[2-(p-toluenesulfonyloxy)ethoxy]ethyl] Ether; ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(4-methylbenzenesulfonate); Bis[2-(2-tosyloxyethoxy)ethyl] Ether; MFCD00075239
Molecular Formula(CH3C6H4SO3CH2CH2OCH2CH2)2O
Molecular Weight502.60
Density1.242 g/mL at 25ºC(lit.)
Boiling Point635ºC at 760 mmHg
Appearancecolorless to yellow
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 37860-51-8 |
| Catalog No. | 2A-2180470 |
| Chinese Name | 四乙二醇二对甲苯磺酸酯 |
| Synonyms | TETRAETHYLENE GLYCOL DI-P-TOSYLATE; Tetraethylene Glycol Bis(p-toluenesulfonate); Bis[2-[2-(p-toluenesulfonyloxy)ethoxy]ethyl] Ether; ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(4-methylbenzenesulfonate); Bis[2-(2-tosyloxyethoxy)ethyl] Ether; MFCD00075239 |
| Molecular Formula | (CH3C6H4SO3CH2CH2OCH2CH2)2O |
| Molecular Weight | 502.60 |
| Density | 1.242 g/mL at 25ºC(lit.) |
| Boiling Point | 635ºC at 760 mmHg |
| Appearance | colorless to yellow |
| Storage Condition | room temperature, sealed |
| Application | PROTAC Linker 16 is a PEG-type PROTAC link bridge. PROTAC Linker 16 can be used to synthesize a range of PROTAC molecules. PROTAC molecules contain two different ligands connected by a linking bridge; |
| HTC | 2909309090 |
| PubChem ID | 24860982 |
| MDL Number | MFCD00075239 |
| SMILES | Cc1ccc(S(=O)(=O)OCCOCCOCCOCCOS(=O)(=O)c2ccc(C)cc2)cc1 |
| InChI | InChI=1S/C22H30O9S2/c1-19-3-7-21(8-4-19)32(23,24)30-17-15-28-13-11-27-12-14-29-16-18-31-33(25,26)22-9-5-20(2)6-10-22/h3-10H,11-18H2,1-2H3 |
| InChI Key | SLAONPBUWDUSSO-UHFFFAOYSA-N |
| Beilstein/REAXYS | 1610992 |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| Hazard Symbols | transportation |
| Bioactivity | PROTAC Linker 16 is a polyethylene glycol (PEG)-based PROTAC linker. PROTAC Linker 16 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker Target PEGs References [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. Chemical & Physical Properties Density 1.242 g/mL at 25ºC(lit.) Boiling Point 635ºC at 760 mmHg Molecular Formula C22H30O9S2 Molecular Weight 502.59800 Flash Point >230 °F Exact Mass 502.13300 PSA 131.19000 LogP 4.62560 Index of Refraction n20/D 1.53(lit.) InChIKey SLAONPBUWDUSSO-UHFFFAOYSA-N SMILES Cc1ccc(S(=O)(=O)OCCOCCOCCOCCOS(=O)(=O)c2ccc(C)cc2)cc1 |
| Use of | Properties Name Tetraethylene Glycol DI-P-Tosylate Synonym More Synonyms PROTAC Linker 16 Biological Activity Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker References [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. Chemical & Physical Properties Molecular Formula C22H30O9S2 Exact Mass 502.13300 PSA 131.19000 LogP 4.62560 InChIKey SLAONPBUWDUSSO-UHFFFAOYSA-N |
| Tax Rebate | 9.0% |
| Supervision | none |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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