CAS Number98-92-0
SynonymsNiacinamide; MFCD00006395; Nicotinic acid amide; Vitamin- B3; Witamina PP; 3-Pyridinecarboxamide; Nicotinamide; Pyridine-3-carboxamide; T6NJ CVZ; Dipigyl; EINECS 202-713-4; Vi-noctyl
Molecular FormulaC6H6N2O
Molecular Weight122.12
Purity≥98 (HPLC)%
Density1.2±0.1 g/cm3
Boiling Point257.7±32.0 °C at 760 mmHg
Melting Point128-131 °C (lit.)
Appearancepowder
EINECS202-713-4
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 98-92-0 |
| Catalog No. | 2A-0200173 |
| Chinese Name | 烟酰胺 |
| Synonyms | Niacinamide; MFCD00006395; Nicotinic acid amide; Vitamin- B3; Witamina PP; 3-Pyridinecarboxamide; Nicotinamide; Pyridine-3-carboxamide; T6NJ CVZ; Dipigyl; EINECS 202-713-4; Vi-noctyl |
| Molecular Formula | C6H6N2O |
| Molecular Weight | 122.12 |
| Purity | ≥98 (HPLC) |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 257.7±32.0 °C at 760 mmHg |
| Melting Point | 128-131 °C (lit.) |
| Appearance | powder |
| Water Solubility | 1000 g/L (20 ºC) |
| Storage Condition | 1. Store in a cool, dry and well-ventilated wareho |
| Application | Nicotinamide is a B3 vitamin that plays an important role in cellular physiology by promoting NAD+ redox homeostasis and providing NAD+ as a substrate for a class of enzymes that catalyze non-redox re |
| EINECS | 202-713-4 |
| HTC | 2933399090 |
| PubChem ID | 24897434 |
| MDL Number | MFCD00006395 |
| SMILES | NC(=O)c1cccnc1 |
| InChI | 1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) |
| InChI Key | DFPAKSUCGFBDDF-UHFFFAOYSA-N |
| Beilstein/REAXYS | 383619 |
| NACRES Code | NA.75 |
| UNSPSC | 12352205 |
| MSDS | msds/18100_1_98_92_0.pdf |
| Use of | Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1. Properties Articles391 Name 3-Pyridinecarboxamide Synonym More Synonyms Nicotinamide Biological Activity Description Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1. Related Catalog Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin Signaling Pathways >> Epigenetics >> Sirtuin Research Areas >> Neurological Disease Natural Products >> Others Human Endogenous Metabolite References [1]. Bhansali SG, et al. Nicotinamide prevents apoptosis in human cortical neuronal cells. Toxicol Mech Methods. 2006;16(4):173-80. [2]. Roslan J, et al. Quercetin ameliorates oxidative stress, inflammation and apoptosis in the heart of streptozotocin-nicotinamide-induced adult male diabetic rats. Biomed Pharmacother. 2016 Dec 24;86:570-582 [3]. Fushima T, et al. Nicotinamide ameliorates a preeclampsia-like condition in mice with reduced uterine perfusion pressure. Am J Physiol Renal Physiol. 2016 Dec 7:ajprenal.00501.2016 [4]. Suzuki E, et al. Protective effect of nicotinamide against poly(ADP-ribose) polymerase-1-mediated astrocyte death depends on its transporter-mediated uptake. Life Sci. 2010 Apr 24;86(17-18):676-82. Chemical & Physical Properties Molecular Formula C6H6N2O Exact Mass 122.048012 PSA 55.98000 LogP -0.24 Appearance of Characters powder | white Index of Refraction 1.590 InChIKey DFPAKSUCGFBDDF-UHFFFAOYSA-N Stability Stable. Incompatible with strong oxidizing agents. Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Nicotinamide CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C6-H6-N2-O MOLECULAR WEIGHT : WISWESSER LINE NOTATION : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Lungs, Thorax, or Respiration - other changes TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Mammal - species unspecified DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value MUTATION DATA TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Rodent - hamster Ovary DOSE/DURATION : REFERENCE : Safety Information Signal Word Warning Hazard Statements H315-H319-H335 Precautionary Statements P261-P305 + P351 + P338 Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves Hazard Codes Xi Safety Phrases S26;S36 RIDADR NONH for all modes of transport WGK Germany 1 RTECS QS3675000 HS Code 2933399090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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