| Chemical & Physical Properties | |
|---|---|
| CAS Number | 875320-29-9 |
| Catalog No. | 2A-3178156 |
| Chinese Name | JNJ-26481585 |
| Synonyms | Quisinostat [USAN]; QUISINOSTAT; Quisinostat (USAN/INN); S1096_Selleck; UNII-9BJ85K1J8S; JNJ-26481585 |
| Molecular Formula | C21H26N6O2 |
| Molecular Weight | 394.47000 |
| Density | 1.358g/cm3 |
| Boiling Point | 615.103ºC at 760 mmHg |
| Appearance | Light yellow or yellow powder |
| Storage Condition | -20℃ |
| Application | Quisinostat (JNJ-26481585) is an orally active and highly effective HDAC inhibitor with an IC50 value of 0.11 nM for HDAC1. |
| HTC | 2933990090 |
| SMILES | Cn1cc(CNCC2CCN(c3ncc(C(=O)NO)cn3)CC2)c2ccccc21 |
| InChI Key | PAWIYAYFNXQGAP-UHFFFAOYSA-N |
| Use of | Quisinostat (JNJ-26481585) is an orally available, potent HDAC inhibitor with an IC50 of 0.11 nM for HDAC1. Properties Name N-hydroxy-2-[4-[[(1-methylindol-3-yl)methylamino]methyl]piperidin-1-yl]pyrimidine-5-carboxamide Synonym More Synonyms Quisinostat Biological Activity Description Quisinostat (JNJ-26481585) is an orally available, potent HDAC inhibitor with an IC50 of 0.11 nM for HDAC1. Related Catalog Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC Research Areas >> Cancer HDAC1:0.11 nM (IC50) HDAC2:0.33 nM (IC50) HDAC11:0.37 nM (IC50) HDAC10:0.46 nM (IC50) HDAC5:3.69 nM (IC50) HDAC8:4.26 nM (IC50) HDAC3:4.86 nM (IC50) HDAC9:32.1 nM (IC50) HDAC6:76.8 nM (IC50) HDAC7:119 nM (IC50) In Vivo JNJ-26481585 induces continuous H3 acetylation in tumor tissue in vivo. JNJ-26481585, a "second-generation" HDAC inhibitor with prolonged pharmacodynamic response in vivo. In agreement with the hypothesis, JNJ-26481585 showed superior efficacy compared with both standard of care agents and first-generation HDAC inhibitors in preclinical tumor models. These studies suggest that an HDAC inhibitor with continuous pharmacodynamic activity may show activity in solid tumor malignancies[1]. References [1]. Arts J, et al. JNJ-26481585, a novel "second-generation" oral histone deacetylase inhibitor, shows broad-spectrum preclinical antitumoral activity. Clin Cancer Res. 2009 Nov 15;15(22):6841-51. Chemical & Physical Properties Molecular Formula C21H26N6O2 Exact Mass 394.21200 PSA 95.31000 LogP 2.94030 Index of Refraction 1.688 InChIKey PAWIYAYFNXQGAP-UHFFFAOYSA-N Storage condition -20℃ Safety Information HS Code 2933990090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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