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Pralidoxime iodide structure, CAS 94-63-3

Pralidoxime iodide

CAS Number94-63-3

Synonyms2-Pyridinealdoxime methiodide; 2-hydroxyiminomethyl-1-methylpyridinium iodide; EINECS 202-349-6; 1-methyl-2-hydroxyiminomethylpyridinium iodide; Pyridinium, 2-[(E)-(hydroxyimino)methyl]-1-methyl-, iodide (1:1); pralidoximemethiodide; PRALIDOXIMELODIDE; PYRIDINE-2-CARBOXALDOXIME METHIODIDE; PRALIDOXIME IODIDE; MFCD00011982; pyridin-2-aldoxin; p-2-am; 2-PAM; 2-pamiodide; 2-[(E)-(Hydroxyimino)methyl]-1-methylpyridinium iodide; 2-[(hydroxyimino)methyl]-1-methylpyridinium iodide

Molecular FormulaC7H9IN2O

Molecular Weight266.08

Purity99%

Density1.7439 g/ml

Boiling Point

Melting Point220 °C (dec.) (lit.)

Flash Point

Appearancesolid

EINECS202-349-6

MSDSChineseEnglish

SymbolTransport

Signal WordWarning

Cat. No.: 2A-9017862 Purity: 99%
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Quality Control of [ 94-63-3 ] Purity: 99% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number94-63-3
Catalog No.2A-9017862
Chinese Name碘解磷定
Synonyms2-Pyridinealdoxime methiodide; 2-hydroxyiminomethyl-1-methylpyridinium iodide; EINECS 202-349-6; 1-methyl-2-hydroxyiminomethylpyridinium iodide; Pyridinium, 2-[(E)-(hydroxyimino)methyl]-1-methyl-, iodide (1:1); pralidoximemethiodide; PRALIDOXIMELODIDE; PYRIDINE-2-CARBOXALDOXIME METHIODIDE; PRALIDOXIME IODIDE; MFCD00011982; pyridin-2-aldoxin; p-2-am; 2-PAM; 2-pamiodide; 2-[(E)-(Hydroxyimino)methyl]-1-methylpyridinium iodide; 2-[(hydroxyimino)methyl]-1-methylpyridinium iodide
Molecular FormulaC7H9IN2O
Molecular Weight266.08
Purity99
Density1.7439 g/ml
Melting Point220 °C (dec.) (lit.)
Appearancesolid
Storage ConditionStore at room temperature in a cool and ventilated
ApplicationPralidoxime iodide is an activator of acetylcholinesterase (AChE). Pralidoxime iodide can activate nerve agents and inhibit the activity of acetylcholinesterase through direct nucleophilic attack by b
EINECS202-349-6
PubChem ID24898726
MDL NumberMFCD00011982
SMILES[I-].C[n+]1ccccc1\C=N\O
InChI1S/C7H8N2O.HI/c1-9-5-3-2-4-7(9)6-8-10;/h2-6H,1H3;1H
InChI KeyQNBVYCDYFJUNLO-UHFFFAOYSA-N
NACRES CodeNA.22
UNSPSC12352100
Hazard SymbolsTransport
MSDSmsds/17862_1_94_63_3.pdf
BioactivityPralidoxime iodide is a reactivator of acetylcholinesterase (AChE). Pralidoxime iodide reactivates nerve agent, which inhibits AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime iodide is an antidote for organophosphate poisoning[1][2]. Related Catalog Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE In Vivo Pralidoxime iodide (10-150 mg/kg; i.m.) reverses paraoxon-induced respiratory toxicity in mice[3]. Animal Model: Male F1B6D2 mice (toxic but non-lethal model of diethylparaoxon in awake, unrestrained mice)[3] Dosage: 10, 50, 100 and 150 mg/kg Administration: Intramuscularly Result: Reversal of diethylparaoxon-induced respiratory toxicity at 150 mg/kg. References [1]. Cadieux CL, et al. Probing the activity of a non-oxime reactivator for acetylcholinesterase inhibited by organophosphorus nerve agents. Chem Biol Interact. 2016;259(Pt B):133‐141. [2]. Eyer P, Buckley N. Pralidoxime for organophosphate poisoning. Lancet. 2006;368(9553):2110‐2111. [3]. Houzé P, et al. High Dose of Pralidoxime Reverses Paraoxon-Induced Respiratory Toxicity in Mice. Turk J Anaesthesiol Reanim. 2018;46(2):131‐138. Chemical & Physical Properties Density 1.7439 g/ml Melting Point 220 °C (dec.)(lit.) Molecular Formula C7H9IN2O Molecular Weight 264.064 Exact Mass 263.975952 PSA 36.47000 InChIKey QNBVYCDYFJUNLO-UHFFFAOYSA-O SMILES C[n+]1ccccc1C=NO.I Storage condition 2-8°C
Use ofPralidoxime iodide is a reactivator of acetylcholinesterase (AChE). Pralidoxime iodide reactivates nerve agent, which inhibits AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime iodide is an antidote for organophosphate poisoning[1][2]. Properties Articles38 Name pralidoxime iodide Synonym More Synonyms Pralidoxime Iodide Biological Activity Description Pralidoxime iodide is a reactivator of acetylcholinesterase (AChE). Pralidoxime iodide reactivates nerve agent, which inhibits AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime iodide is an antidote for organophosphate poisoning[1][2]. Related Catalog Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE References [1]. Cadieux CL, et al. Probing the activity of a non-oxime reactivator for acetylcholinesterase inhibited by organophosphorus nerve agents. Chem Biol Interact. 2016;259(Pt B):133‐141. [2]. Eyer P, Buckley N. Pralidoxime for organophosphate poisoning. Lancet. 2006;368(9553):2110‐2111. [3]. Houzé P, et al. High Dose of Pralidoxime Reverses Paraoxon-Induced Respiratory Toxicity in Mice. Turk J Anaesthesiol Reanim. 2018;46(2):131‐138. Chemical & Physical Properties Molecular Formula C7H9IN2O Exact Mass 263.975952 PSA 36.47000 InChIKey QNBVYCDYFJUNLO-UHFFFAOYSA-O
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available
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