CAS Number21414-41-5
SynonymsGLUCORAPHANIN POTASSIUM SALT(RG); 1-S-[5-(methylsulfinyl)-N-(sulfonatooxy)pentanimidoyl]-1-thio-β-D-glucopyranose; β-D-Glucopyranose, 1-thio-,1-(5-(methylsulfinyl)-N-(sulfooxy)pentanimidate); 4-(methylsulfinyl)butyl-glucosinolate; 4-methylsufinylbutyl glucosinolate; 4-Methylsulphinylbutyl glucosinolate; 1-S-[(1E)-5-(Methylsulfinyl)-N-(sulfonatooxy)pentanimidoyl]-1-thio-β-D-glucopyranose; GLUCORAPHANIN; β-D-Glucopyranose, 1-S-[(1E)-5-(methylsulfinyl)-1-[(sulfooxy)imino]pentyl]-1-thio-, ion(1-)
Molecular FormulaC12H23NO10S3
Molecular Weight475.60
Purity≥95.0 (HPLC)%
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| Chemical & Physical Properties | |
|---|---|
| CAS Number | 21414-41-5 |
| Catalog No. | 2A-1177820 |
| Chinese Name | 萝卜硫苷 |
| Synonyms | GLUCORAPHANIN POTASSIUM SALT(RG); 1-S-[5-(methylsulfinyl)-N-(sulfonatooxy)pentanimidoyl]-1-thio-β-D-glucopyranose; β-D-Glucopyranose, 1-thio-,1-(5-(methylsulfinyl)-N-(sulfooxy)pentanimidate); 4-(methylsulfinyl)butyl-glucosinolate; 4-methylsufinylbutyl glucosinolate; 4-Methylsulphinylbutyl glucosinolate; 1-S-[(1E)-5-(Methylsulfinyl)-N-(sulfonatooxy)pentanimidoyl]-1-thio-β-D-glucopyranose; GLUCORAPHANIN; β-D-Glucopyranose, 1-S-[(1E)-5-(methylsulfinyl)-1-[(sulfooxy)imino]pentyl]-1-thio-, ion(1-) |
| Molecular Formula | C12H23NO10S3 |
| Molecular Weight | 475.60 |
| Purity | ≥95.0 (HPLC) |
| Storage Condition | 2-8℃ |
| Application | Glucoraphanin is a glucosinolate found in cruciferous vegetables and is the precursor of the Nrf2 inducer sulforaphane, which has antioxidant, anti-inflammatory, and anti-cancer effects. |
| HTC | 2932999099 |
| SMILES | CS(=O)CCCCC(=NOS(=O)(=O)O)SC1OC(CO)C(O)C(O)C1O |
| InChI | 1S/C12H23NO10S3/c1-25(18)5-3-2-4-8(13-23-26(19,20)21)24-12-11(17)10(16)9(15)7(6-14)22-12/h7,9-12,14-17H,2-6H2,1H3,(H,19,20,21)/b13-8+/t7-,9-,10+,11-,12+,25?/m1/s1 |
| InChI Key | GMMLNKINDDUDCF-RFOBZYEESA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/178422_1_21414_41_5.pdf |
| Use of | Glucoraphanin, a natural glucosinolate found in cruciferous vegetable, is a stable precursor of the Nrf2 inducer sulforaphane, which possesses antioxidant, anti-inflammatory, and anti-carcinogenic effects. Properties Name glucoraphanin Synonym More Synonyms Glucoraphanin Biological Activity Description Glucoraphanin, a natural glucosinolate found in cruciferous vegetable, is a stable precursor of the Nrf2 inducer sulforaphane, which possesses antioxidant, anti-inflammatory, and anti-carcinogenic effects. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Cancer Natural Products >> Saccharides and Glycosides In Vivo Glucoraphanin reduces weight gain and increases energy expenditure in HFD-fed mice. Glucoraphanin can improves insulin sensitivity and glucose tolerance in HFD-fed mice. However, Glucoraphanin does not exert antiobesity and insulin-sensitizing effects in Nrf2−/− Mice. Glucoraphanin blocks HFD-induced reduction of Ucp1 protein levels in white adipose depots of wild-type mice but not in Nrf2−/− mice. Glucoraphanin alleviates HFD-induced hepatic steatosis and oxidative stress. Glucoraphanin suppresses HFD-induced proinflammatory activation of macrophages in liver and adipose tissue. Glucoraphanin also decreases circulating LPS and the relative abundance of proteobacteria in the gut microbiomes of HFD-fed mice[1]. Mice with pellets including 0.1% Glucoraphanin (GF) significantly attenuates the decreased social avoidance time in stressed mice. In the 1% sucrose preference test (SPT), treatment with pellets including 0.1% GF significantly attenuates the decreased sucrose preference of stressed mice[2]. References [1]. Nagata N, et al. Glucoraphanin Ameliorates Obesity and Insulin Resistance Through Adipose Tissue Browning and Reduction of Metabolic Endotoxemia in Mice. Diabetes. 2017 May;66(5):1222-1236. [2]. Yao W, et al. Role of Keap1-Nrf2 signaling in depression and dietary intake of glucoraphanin confers stress resilience in mice. Sci Rep. 2016 Jul 29;6:30659. Chemical & Physical Properties Molecular Formula C12H23NO10S3 Exact Mass 436.041138 PSA 236.07000 LogP -0.53 InChIKey GMMLNKINDDUDCF-BYNGITTOSA-N SMILES CS(=O)CCCCC(=NOS(=O)(=O)O)SC1OC(CO)C(O)C(O)C1O Storage condition 2-8℃ Safety Information HS Code 2932999099 Precursor & DownStream Precursor 0 DownStream 1 CAS#:4478-93-7 DL-Sulforaphane |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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