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HC TOXIN structure, CAS 83209-65-8

HC TOXIN

CAS Number83209-65-8

SynonymsMFCD00133388; Toxin I; HC TOXIN

Molecular FormulaC21H32N4O6

Molecular Weight436.50

Purity99.9%

Density1.3±0.1 g/cm3

Boiling Point819.2±65.0 °C at 760 mmHg

Melting Point

Flash Point

Appearancesolid

EINECS

MSDSChineseEnglish

Symboltransportation

Signal WordWarning

Cat. No.: 2A-1177727 Purity: 99.9%
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Quality Control of [ 83209-65-8 ] Purity: 99.9% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number83209-65-8
Catalog No.2A-1177727
Chinese NameHC毒素
SynonymsMFCD00133388; Toxin I; HC TOXIN
Molecular FormulaC21H32N4O6
Molecular Weight436.50
Purity99.9
Density1.3±0.1 g/cm3
Boiling Point819.2±65.0 °C at 760 mmHg
Appearancesolid
Storage ConditionSealed in a cool, dry environment at 2-8 ºC
ApplicationHC toxin is a cyclic tetrapeptide and a potent HDAC inhibitor with an IC50 of 30 nM [1]. HC toxin induces tumor cell apoptosis and has anti-cancer effects [2].
SMILES[H+].[I-][Pb+2]([I-])[I-].N=CN
InChIInChI=1S/CH4N2.3HI.Pb/c2-1-3;;;;/h1H,(H3,2,3);3*1H;/q;;;;+2/p-2
InChI KeyGNYCTMYOHGBSBI-KVUCBBCISA-N
Hazard Symbolstransportation
BioactivityHC-Toxin, a cyclic tetrapeptide, is a potent HDAC inhibitor with an IC50 of 30 nM[1]. HC-Toxin induces tumor cell apoptosis and has anticancer effects[2]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC In Vitro HC-Toxin shows potent antiproliferative efficacy and cell cycle arrest at G2/M in T47D human breast cancer cells in a dose-dependent manner. HC-Toxin evokes apoptosis of T47D cells and HC-toxin induced apoptosis might not be mediated through direct increase in caspase-3/7 activity[2]. References [1]. S J Darkin-Rattray, et al. Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13143-7. [2]. Ki Eun Joung, et al. Antiproliferative effect of trichostatin A and HC-toxin in T47D human breast cancer cells. Arch Pharm Res. 2004 Jun;27(6):640-5. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 819.2±65.0 °C at 760 mmHg Molecular Formula C21H32N4O6 Molecular Weight 436.50 Flash Point 449.2±34.3 °C Exact Mass 436.232178 PSA 137.21000 LogP -2.99 Vapour Pressure 0.0±3.0 mmHg at 25°C Index of Refraction 1.562 InChIKey GNYCTMYOHGBSBI-KVUCBBCISA-N SMILES CC1NC(=O)C(C)NC(=O)C2CCCN2C(=O)C(CCCCCC(=O)C2CO2)NC1=O
Use ofHC-Toxin, a cyclic tetrapeptide, is a potent HDAC inhibitor with an IC50 of 30 nM[1]. HC-Toxin induces tumor cell apoptosis and has anticancer effects[2]. Properties Articles27 Name HC toxin Synonym More Synonyms HC Toxin Biological Activity Description HC-Toxin, a cyclic tetrapeptide, is a potent HDAC inhibitor with an IC50 of 30 nM[1]. HC-Toxin induces tumor cell apoptosis and has anticancer effects[2]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC References [1]. S J Darkin-Rattray, et al. Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13143-7. [2]. Ki Eun Joung, et al. Antiproliferative effect of trichostatin A and HC-toxin in T47D human breast cancer cells. Arch Pharm Res. 2004 Jun;27(6):640-5. Chemical & Physical Properties Molecular Formula C21H32N4O6 Exact Mass 436.232178 PSA 137.21000 LogP -2.99 Index of Refraction 1.562 InChIKey GNYCTMYOHGBSBI-KVUCBBCISA-N
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 Names specified by the United Nations (UN) European land transport hazard regulations: TOXIC SOLID, ORGANIC, N.O.S. (HC toxin from Helminthosporium carbonum) IMDG Code: TOXIC SOLID, ORGANIC, N.O.S. (HC toxin from Helminthosporium carbonum) International air transport hazard regulations: Toxic solid, organic, n.o.s. (HC toxin from Helminthosporium carbonum) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available
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