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2',4',6'-Trihydroxyacetophenone

Name: 2',4',6'-Trihydroxyacetophenone
Brand: 2A Biotech
SKU: 2A-9001783

CAS Number480-66-0

Synonyms1-(2,4,6-Trihydroxyphenyl)-ethanone; 2-Acetylphloroglucinol; EINECS 207-556-5; 2-Acetylphloroglucinol Monohydrate; 2-Acetylphloroglucinol,THAP; 2',4',6'-Trihydroxyaceto-phenone; 1-(2,4,6-Trihydroxyphenyl)ethanone; MFCD00002287

Molecular FormulaC8H8O4

Molecular Weight168.151

Purity98%

Density1.4±0.1 g/cm3

Boiling Point333.2±22.0 °C at 760 mmHg

Melting Point219-221 °C(lit.)

Appearancelight yellow crystal

MSDSChinese English

Symbol

Signal WordWarning

Cat. No.: 2A-9001783 Purity: 98%

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Quality Control of [ 480-66-0 ] Purity: 98% SDS Specification MoL

Chemical & Physical Properties
CAS Number	480-66-0
Catalog No.	2A-9001783
Chinese Name	2',4',6'-三羟基苯乙酮
Synonyms	1-(2,4,6-Trihydroxyphenyl)-ethanone; 2-Acetylphloroglucinol; EINECS 207-556-5; 2-Acetylphloroglucinol Monohydrate; 2-Acetylphloroglucinol,THAP; 2',4',6'-Trihydroxyaceto-phenone; 1-(2,4,6-Trihydroxyphenyl)ethanone; MFCD00002287
Molecular Formula	C8H8O4
Molecular Weight	168.151
Purity	98
Density	1.4±0.1 g/cm3
Boiling Point	333.2±22.0 °C at 760 mmHg
Melting Point	219-221 °C(lit.)
Appearance	light yellow crystal
Storage Condition	Store in a sealed container in a ventilated and dr
Application	Phloracetophenone (2,4,6-trihydroxyacetophenone) is the aglycone part of the acetophenone glycoside in Curcuma comosa Roxb. It has a cholesterol-lowering effect and can enhance the activity of cholest
HTC	2942000000
MDL Number	MFCD00002287
SMILES	CC(=O)c1c(O)cc(O)cc1O
InChI	InChI=1S/C8H8O4/c1-4(9)8-6(11)2-5(10)3-7(8)12/h2-3,10-12H,1H3
InChI Key	XLEYFDVVXLMULC-UHFFFAOYSA-N
Hazard Symbols	Transport
MSDS	msds/1783_1_480_66_0.pdf
Bioactivity	Phloracetophenone (2,4,6-trihydroxyacetophenone) is the aglycone part of acetophenone glycoside obtained from Curcuma comosa Roxb, with cholesterol-lowering activity. Phloracetophenone enhances cholesterol 7α-hydroxylase (CYP7A1) activity[1]. Phloracetophenone stimulats bile secretion mediated through Mrp2[2]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Others Natural Products >> Phenols Target Cholesterol 7α-hydroxylase[1], Mrp2[2] In Vitro Phloracetophenone (2,4,6-trihydroxyacetophenone) is a cholesterol-lowering agent, enhances cholesterol 7α-hydroxylase (CYP7A1) activity, and elevates CYP7A1 mRNA level[1]. Phloracetophenone (1, 2, and 4 μmol/min) immediately and dose-dependently increases bile acid-independent bile flow in the isolated perfused rat liver[2]. In Vivo Phloracetophenone (2,4,6-trihydroxyacetophenone; 125 or 250 μmol/kg, intraduodenal injection) shows choleretic activity requiring multidrug resistance protein-2 (Mrp2) in rats. Phloracetophenone (40 μmol/min) partially prevents the E2-17G induced cholestasis[2]. References [1]. Charoenteeraboon J, et al. Induction of human cholesterol 7alpha-hydroxylase in HepG2 cells by 2,4,6-trihydroxyacetophenone. Eur J Pharmacol. 2005 May 16;515(1-3):43-6. [2]. Piyachaturawat P, et al. Choleretic activity of phloracetophenone in rats: structure-function studies using acetophenone analogues. Eur J Pharmacol. 2000 Jan 10;387(2):221-7. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 333.2±22.0 °C at 760 mmHg Melting Point 219-221 °C(lit.) Molecular Formula C8H8O4 Molecular Weight 168.147 Flash Point 169.5±18.8 °C Exact Mass 168.042252 PSA 77.76000 LogP 2.07 Vapour Pressure 0.0±0.8 mmHg at 25°C Index of Refraction 1.641 InChIKey XLEYFDVVXLMULC-UHFFFAOYSA-N SMILES CC(=O)c1c(O)cc(O)cc1O Storage condition Refrigerator
Use of	Phloracetophenone (2,4,6-trihydroxyacetophenone) is the aglycone part of acetophenone glycoside obtained from Curcuma comosa Roxb, with cholesterol-lowering activity. Phloracetophenone enhances cholesterol 7α-hydroxylase (CYP7A1) activity[1]. Phloracetophenone stimulats bile secretion mediated through Mrp2[2]. Properties Articles15 Name 2',4',6'-trihydroxyacetophenone Synonym More Synonyms Biological Activity Description Phloracetophenone (2,4,6-trihydroxyacetophenone) is the aglycone part of acetophenone glycoside obtained from Curcuma comosa Roxb, with cholesterol-lowering activity. Phloracetophenone enhances cholesterol 7α-hydroxylase (CYP7A1) activity[1]. Phloracetophenone stimulats bile secretion mediated through Mrp2[2]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Others Natural Products >> Phenols Cholesterol 7α-hydroxylase[1], Mrp2[2] In Vivo Phloracetophenone (2,4,6-trihydroxyacetophenone; 125 or 250 μmol/kg, intraduodenal injection) shows choleretic activity requiring multidrug resistance protein-2 (Mrp2) in rats. Phloracetophenone (40 μmol/min) partially prevents the E2-17G induced cholestasis[2]. References Chemical & Physical Properties Molecular Formula C8H8O4 Exact Mass 168.042252 PSA 77.76000 Index of Refraction 1.641 InChIKey XLEYFDVVXLMULC-UHFFFAOYSA-N Storage condition Refrigerator
Tax Rebate	9.0%
Supervision	none
Transport Info	Shipping Name: UN
MSDS Transport Info	Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available

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2',4',6'-Trihydroxyacetophenone

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