CAS Number92-43-3
Synonyms1-Phenyl-3-pyrazolidinone; PYRAZOLIDONE A; 1-Phenyl-3-oxopyrazolidine; Fenidon; 1-phenylpyrazolidin-3-one; 1-hydro-2-phenyl-pyrazol-5-one; phenitone; N-phenylpyrazolidin-3-one; 1-P-3-P; 1-Phenyl-3-pyrazolidone; UNII-H0U5612P6K; PHENIDONE A; 1-phenyl-1H-pyrazolidin-3-one; MFCD00003094; A PHENIDONE A; B PHENIDONE B; S PHENIDONE S; 1-phenyl-pyrazolidin-3-on; EINECS 202-155-1; graphidone
Molecular FormulaC9H10N2O
Molecular Weight162.19
Purity97%
Density1.2±0.1 g/cm3
Boiling Point304.1±25.0 °C at 760 mmHg
Melting Point119-121 °C (lit.)
Appearancepowder
EINECS202-155-1
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 92-43-3 |
| Catalog No. | 2A-9017747 |
| Chinese Name | 菲尼酮 |
| Synonyms | 1-Phenyl-3-pyrazolidinone; PYRAZOLIDONE A; 1-Phenyl-3-oxopyrazolidine; Fenidon; 1-phenylpyrazolidin-3-one; 1-hydro-2-phenyl-pyrazol-5-one; phenitone; N-phenylpyrazolidin-3-one; 1-P-3-P; 1-Phenyl-3-pyrazolidone; UNII-H0U5612P6K; PHENIDONE A; 1-phenyl-1H-pyrazolidin-3-one; MFCD00003094; A PHENIDONE A; B PHENIDONE B; S PHENIDONE S; 1-phenyl-pyrazolidin-3-on; EINECS 202-155-1; graphidone |
| Molecular Formula | C9H10N2O |
| Molecular Weight | 162.19 |
| Purity | 97 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 304.1±25.0 °C at 760 mmHg |
| Melting Point | 119-121 °C (lit.) |
| Appearance | powder |
| Water Solubility | SOLUBLE IN HOT WATER |
| Storage Condition | This product should be stored in a sealed, cool, d |
| Packaging | III |
| Application | Phenidone, an orally active, dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), improves paralysis in rats with experimental autoimmune encephalomyelitis. Phenidone is an effective antihyp |
| EINECS | 202-155-1 |
| HTC | 2933199090 |
| PubChem ID | 24847805 |
| MDL Number | MFCD00003094 |
| SMILES | O=C1CCN(N1)c2ccccc2 |
| InChI | 1S/C9H10N2O/c12-9-6-7-11(10-9)8-4-2-1-3-5-8/h1-5H,6-7H2,(H,10,12) |
| InChI Key | CMCWWLVWPDLCRM-UHFFFAOYSA-N |
| Beilstein/REAXYS | 131856 |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| Hazard Symbols | 6.1 |
| MSDS | msds/17747_1_92_43_3.pdf |
| Bioactivity | Phenidone, an orally active dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), ameliorates rat paralysis in experimental autoimmune encephalomyelitis. Phenidone is a potent hypotensive agent in the spontaneously hypertensive rat[1][2]. Phenidone is used as a photographic developer[3]. Related Catalog Research Areas >> Cardiovascular Disease Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase Target COX LOX In Vitro Phenidone significantly inhibits the increases in COX-1/-2 and 5-LOX in the spinal cords of rats with experimental autoimmune encephalomyelitis (EAE)[1]. In Vivo Phenidone inhibits the formation of vascular lipoxygenase products and to reduce blood pressure in the AII-dependent renovascular hypertensive rat[2]. References [1]. Moon C, et al. Phenidone, a dual inhibitor of cyclooxygenases and lipoxygenases, ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes. Brain Res. 2005;1035(2):206-210. [2]. Stern N, et al. The lipoxygenase inhibitor phenidone is a potent hypotensive agent in the spontaneously hypertensive rat. Am J Hypertens. 1993;6(1):52-58. [3]. Petrakiev A, et al. Emission spectral analysis using photographic plates treated with a phenidone developer. Talanta. 1969;16(12):1583-1587. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 304.1±25.0 °C at 760 mmHg Melting Point 119-121 °C(lit.) Molecular Formula C9H10N2O Molecular Weight 162.189 Flash Point 137.7±23.2 °C Exact Mass 162.079315 PSA 32.34000 LogP 0.20 Vapour Pressure 0.0±0.7 mmHg at 25°C Index of Refraction 1.620 InChIKey CMCWWLVWPDLCRM-UHFFFAOYSA-N SMILES O=C1CCN(c2ccccc2)N1 Stability Stable, but light sensitive. Incompatible with strong acids, strong oxidizing agents, strong bases. Water Solubility SOLUBLE IN HOT WATER |
| Use of | Phenidone, an orally active dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), ameliorates rat paralysis in experimental autoimmune encephalomyelitis. Phenidone is a potent hypotensive agent in the spontaneously hypertensive rat[1][2]. Phenidone is used as a photographic developer[3]. Properties Articles31 Name Phenidone Synonym More Synonyms Phenidone Biological Activity Description Phenidone, an orally active dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), ameliorates rat paralysis in experimental autoimmune encephalomyelitis. Phenidone is a potent hypotensive agent in the spontaneously hypertensive rat[1][2]. Phenidone is used as a photographic developer[3]. Related Catalog Research Areas >> Cardiovascular Disease Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase In Vivo Phenidone inhibits the formation of vascular lipoxygenase products and to reduce blood pressure in the AII-dependent renovascular hypertensive rat[2]. References [1]. Moon C, et al. Phenidone, a dual inhibitor of cyclooxygenases and lipoxygenases, ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes. Brain Res. 2005;1035(2):206-210. [2]. Stern N, et al. The lipoxygenase inhibitor phenidone is a potent hypotensive agent in the spontaneously hypertensive rat. Am J Hypertens. 1993;6(1):52-58. [3]. Petrakiev A, et al. Emission spectral analysis using photographic plates treated with a phenidone developer. Talanta. 1969;16(12):1583-1587. Chemical & Physical Properties Molecular Formula C9H10N2O Exact Mass 162.079315 PSA 32.34000 Index of Refraction 1.620 InChIKey CMCWWLVWPDLCRM-UHFFFAOYSA-N Stability Stable, but light sensitive. Incompatible with strong acids, strong oxidizing agents, strong bases. Water Solubility SOLUBLE IN HOT WATER |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.5% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (1-Phenyl-3-pyrazolidone) IMDG Code: TOXIC SOLID, ORGANIC, N.O.S. (1-Phenyl-3-pyrazolidone) International air transport hazard regulations: Toxic solid, organic, n.o.s. (1-Phenyl-3-pyrazolidone) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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