CAS Number932-53-6
Synonyms6-Methyl-2H-[1,2,4]triazin-3,5-dion; USAF CB-28; Azathymine; 6-methyl-2H-[1,2,4]triazine-3,5-dione; Azathymine,6; 6-azathymine; 1,2,4-Triazine-3,5(2H,4H)-dione,6-methyl; 6-methyl-2H-[1,2,4]triazin-3,5-dione; 6-methyl-2,3,4,5-tetrahydro-1,2,4-triazine-3,5-dione; 6-Methyl-1,2,4-triazine-3,5(2H,4H)-dione; 6-methyl-1,2,4-triazine-3,5-diol; 5-Methyl-6-azauracil; MFCD00006457; EINECS 213-253-9
Molecular FormulaC4H5N3O2
Molecular Weight127.1
Purity98.00%
Density1.7±0.1 g/cm3
Melting Point210-212°C
AppearanceSolid;White to Almost white powder to crystal
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 932-53-6 |
| Catalog No. | 2A-1176588 |
| Chinese Name | 6-氮杂胸腺嘧啶 |
| Synonyms | 6-Methyl-2H-[1,2,4]triazin-3,5-dion; USAF CB-28; Azathymine; 6-methyl-2H-[1,2,4]triazine-3,5-dione; Azathymine,6; 6-azathymine; 1,2,4-Triazine-3,5(2H,4H)-dione,6-methyl; 6-methyl-2H-[1,2,4]triazin-3,5-dione; 6-methyl-2,3,4,5-tetrahydro-1,2,4-triazine-3,5-dione; 6-Methyl-1,2,4-triazine-3,5(2H,4H)-dione; 6-methyl-1,2,4-triazine-3,5-diol; 5-Methyl-6-azauracil; MFCD00006457; EINECS 213-253-9 |
| Molecular Formula | C4H5N3O2 |
| Molecular Weight | 127.1 |
| Purity | 98.00 |
| Density | 1.7±0.1 g/cm3 |
| Melting Point | 210-212°C |
| Appearance | Solid;White to Almost white powder to crystal |
| Storage Condition | Keep container sealed and store in a cool, dry pla |
| Application | 6-Azathymine, the 6-nitrogen analog of thymine, is a potent inhibitor of D-3-aminoisobutyrate-pyruvate aminotransferase. 6-Azathymine inhibits DNA biosynthesis and has antibacterial and antiviral acti |
| HTC | 2933699090 |
| MDL Number | C4H5N3O2 |
| SMILES | Cc1n[nH]c(=O)[nH]c1=O |
| InChI | InChI=1S/C4H5N3O2/c1-2-3(8)5-4(9)7-6-2/h1H3,(H2,5,7,8,9) |
| InChI Key | XZWMZFQOHTWGQE-UHFFFAOYSA-N |
| MSDS | msds/177115_1_932_53_6.pdf |
| Bioactivity | 6-Azathymine, a 6-nitrogen analog of thymine, is a potent D-3-aminoisobutyrate-pyruvate aminotransferase inhibitor. 6-Azathymine inhibits the biosynthesis of DNA, and has antibacterial and antiviral activities[1][2][3][4]. Related Catalog Signaling Pathways >> Anti-infection >> Influenza Virus Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Signaling Pathways >> Anti-infection >> Bacterial In Vitro 6-Azathymine is a competitive antagonist of the growth of Streptococcus faecalis (8043) and several other strains of microorganisms. Studies of the mechanism of action of 6-Azathymine reveal that S. faecalis can convert the analog to the corresponding deoxyriboside, azathymidine[2]. References [1]. N Tamaki, et al. Purification, Characterization and Inhibition of D-3-aminoisobutyrate Aminotransferase From the Rat Liver. Eur J Biochem. 1990 Apr 20;189(1):39-45. [2]. W H PRUSOFF, et al. Effect of the Deoxyriboside of 6-azathymine (Azathymidine) on the Biosynthesis of Deoxyribonucleic Acid by Bone Marrow and Neoplastic Cells (In Vitro). Biochim Biophys Acta. 1956 Apr;20(1):209-14. [3]. R A GAITO, et al. Studies on the Metabolism of Thymine and 6-azathymine. Biochem Pharmacol. Apr-May 1962;11:323-36. [4]. B. Gabrielsen, et al. In vitro and in vivo antiviral (RNA) evaluation of orotidine 51-monophosphatedecarboxylase inhibitors and analogues including 6-azauridine-51-(ethylmethoxyalaninyl)phosphate (a 51-monophosphate prodrug). Antiviral Chemistry & Chemotherapy (1994) 5(4), 209-220. Chemical & Physical Properties Density 1.7±0.1 g/cm3 Melting Point 210-212°C Molecular Formula C4H5N3O2 Molecular Weight 127.101 Exact Mass 127.038177 PSA 78.61000 LogP -2.05 Index of Refraction 1.692 InChIKey XZWMZFQOHTWGQE-UHFFFAOYSA-N SMILES Cc1n[nH]c(=O)[nH]c1=O |
| Use of | 6-Azathymine, a 6-nitrogen analog of thymine, is a potent D-3-aminoisobutyrate-pyruvate aminotransferase inhibitor. 6-Azathymine inhibits the biosynthesis of DNA, and has antibacterial and antiviral activities[1][2][3][4]. Properties Name 6-methyl-2H-1,2,4-triazine-3,5-dione Synonym More Synonyms 6-Azathymine Biological Activity Description 6-Azathymine, a 6-nitrogen analog of thymine, is a potent D-3-aminoisobutyrate-pyruvate aminotransferase inhibitor. 6-Azathymine inhibits the biosynthesis of DNA, and has antibacterial and antiviral activities[1][2][3][4]. Related Catalog Signaling Pathways >> Anti-infection >> Influenza Virus Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Signaling Pathways >> Anti-infection >> Bacterial In Vitro 6-Azathymine is a competitive antagonist of the growth of Streptococcus faecalis (8043) and several other strains of microorganisms. Studies of the mechanism of action of 6-Azathymine reveal that S. faecalis can convert the analog to the corresponding deoxyriboside, azathymidine[2]. References [1]. N Tamaki, et al. Purification, Characterization and Inhibition of D-3-aminoisobutyrate Aminotransferase From the Rat Liver. Eur J Biochem. 1990 Apr 20;189(1):39-45. [2]. W H PRUSOFF, et al. Effect of the Deoxyriboside of 6-azathymine (Azathymidine) on the Biosynthesis of Deoxyribonucleic Acid by Bone Marrow and Neoplastic Cells (In Vitro). Biochim Biophys Acta. 1956 Apr;20(1):209-14. [3]. R A GAITO, et al. Studies on the Metabolism of Thymine and 6-azathymine. Biochem Pharmacol. Apr-May 1962;11:323-36. [4]. B. Gabrielsen, et al. In vitro and in vivo antiviral (RNA) evaluation of orotidine 51-monophosphatedecarboxylase inhibitors and analogues including 6-azauridine-51-(ethylmethoxyalaninyl)phosphate (a 51-monophosphate prodrug). Antiviral Chemistry & Chemotherapy (1994) 5(4), 209-220. Chemical & Physical Properties Molecular Formula C4H5N3O2 Exact Mass 127.038177 PSA 78.61000 LogP -2.05 Index of Refraction 1.692 InChIKey XZWMZFQOHTWGQE-UHFFFAOYSA-N SMILES Cc1n[nH]c(=O)[nH]c1=O |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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