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PF03716556 structure, CAS 928774-43-0

PF03716556

CAS Number928774-43-0

SynonymsPF 03716556; PF03716556; PF-3716556

Molecular FormulaC22H26N4O3

Molecular Weight394.467

Purity

Density1.3±0.1 g/cm3

Boiling Point

Melting Point143-145°C

Flash Point

Appearancewhite to tan

EINECS

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-1175022 Purity:
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Quality Control of [ 928774-43-0 ] SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number928774-43-0
Catalog No.2A-1175022
Chinese NamePF 03716556
SynonymsPF 03716556; PF03716556; PF-3716556
Molecular FormulaC22H26N4O3
Molecular Weight394.467
Density1.3±0.1 g/cm3
Melting Point143-145°C
Appearancewhite to tan
Water SolubilityDMSO: ≥10mg/mL
Storage ConditionRefrigerator
PubChem ID56459702
SMILESCc1cn2cc(C(=O)N(C)CCO)cc(NC3CCOc4cccc(C)c43)c2n1
InChIInChI=1S/C22H26N4O3/c1-14-5-4-6-19-20(14)17(7-10-29-19)24-18-11-16(22(28)25(3)8-9-27)13-26-12-15(2)23-21(18)26/h4-6,11-13,17,24,27H,7-10H2,1-3H3/t17-/m1/s1
InChI KeyYBHKBMJREUZHOV-QGZVFWFLSA-N
MSDSmsds/175427_2_928774_43_0.pdf
BioactivityPF 03716556 is a potent, and selective acid pump (H+,K+ ATPase) antagonist, with pIC50 value of 6.009.IC50 value:6.009 (pIC50)Target: H+,K+ ATPasePF-03716556 inhibited the activity of H+, K+-ATPase with pIC50 of 6.026 ± 0.112, 6.038 ± 0.039 and 6.009 ± 0.209 at pH 6.4 for porcine, canine and human ion-leaky membrane vesicles, respectively. PF-03716556 (PF03716556) is useful for treatment of gastroesophageal reflux disease. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Research Areas >> Metabolic Disease References [1]. Mori et al (2009) N-(2-hydroxyethyl)-N,2-dimethyl-8-{[(4R)-5-methyl-3,4-dihydro-2H-chromen-4-yl]amino}imidazo[1,2-a]py ridine-6-carboxamide (PF-03716556), a novel, potent, and selective acid pump antagonist for the treatment of gastroesophageal reflux disease Chemical & Physical Properties Density 1.3±0.1 g/cm3 Melting Point 143-145°C Molecular Formula C22H26N4O3 Molecular Weight 394.467 Exact Mass 394.200500 PSA 79.10000 LogP 2.60 Appearance of Characters white to tan Index of Refraction 1.651 InChIKey YBHKBMJREUZHOV-QGZVFWFLSA-N SMILES Cc1cn2cc(C(=O)N(C)CCO)cc(NC3CCOc4cccc(C)c43)c2n1 Storage condition Refrigerator Water Solubility DMSO: ≥10mg/mL
Use ofProperties Name N-(2-hydroxyethyl)-N,2-dimethyl-8-[[(4R)-5-methyl-3,4-dihydro-2H-chromen-4-yl]amino]imidazo[1,2-a]pyridine-6-carboxamide Synonym More Synonyms PF-3716556 Biological Activity Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Research Areas >> Metabolic Disease References [1]. Mori et al (2009) N-(2-hydroxyethyl)-N,2-dimethyl-8-{[(4R)-5-methyl-3,4-dihydro-2H-chromen-4-yl]amino}imidazo[1,2-a]py ridine-6-carboxamide (PF-03716556), a novel, potent, and selective acid pump antagonist for the treatment of gastroesophageal reflux disease Chemical & Physical Properties Molecular Formula C22H26N4O3 Exact Mass 394.200500 PSA 79.10000 Appearance of Characters white to tan Index of Refraction 1.651 InChIKey YBHKBMJREUZHOV-QGZVFWFLSA-N Storage condition Refrigerator
Transport InfoProduct name: PF-3716556
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