CAS Number62568-57-4
Synonymstrp-ala-gly-gly-asp-ala-ser-gly-glu; UNII:YN28Z5YZ73; trp-ala-gly-gly-asn-ala-ser-gly-glu; sleep inducing peptide; emideltide; waggdasge; TRP-ALA-GLY-GLY-ASP-ALA-SER: PO3H2-GLY-GLU [WAGGDA-S: PO3H2-GE]; δ-Sleep Inducing Peptide
Molecular FormulaC35H48N10O15
Molecular Weight848.814
Density1.5±0.1 g/cm3
Boiling Point1522.7±65.0 °C at 760 mmHg
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 62568-57-4 |
| Catalog No. | 2A-1174890 |
| Chinese Name | 依米地肽 |
| Synonyms | trp-ala-gly-gly-asp-ala-ser-gly-glu; UNII:YN28Z5YZ73; trp-ala-gly-gly-asn-ala-ser-gly-glu; sleep inducing peptide; emideltide; waggdasge; TRP-ALA-GLY-GLY-ASP-ALA-SER: PO3H2-GLY-GLU [WAGGDA-S: PO3H2-GE]; δ-Sleep Inducing Peptide |
| Molecular Formula | C35H48N10O15 |
| Molecular Weight | 848.814 |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 1522.7±65.0 °C at 760 mmHg |
| Water Solubility | Soluble in water at 0.5mg/ml |
| Storage Condition | −20°C |
| Application | δ-Sleep Inducing Peptide is a neuropeptide with antioxidant and anxiolytic effects. |
| PubChem ID | 8192363 |
| SMILES | CC(NC(=O)C(N)Cc1c[nH]c2ccccc12)C(=O)NCC(=O)NCC(=O)NC(CC(=O)O)C(=O)NC(C)C(=O)NC(CO)C(=O)NCC(=O)NC(CCC(=O)O)C(=O)O |
| InChI | InChI=1S/C35H48N10O15/c1-16(41-32(56)20(36)9-18-11-37-21-6-4-3-5-19(18)21)30(54)39-12-25(47)38-13-26(48)44-23(10-29(52)53)34(58)42-17(2)31(55)45-24(15-46)33(57)40-14-27(49)43-22(35(59)60)7-8-28(50)51/h3-6,11,16-17,20,22-24,37,46H,7-10,12-15,36H2,1-2H3,(H,38,47)(H,39,54)(H,40,57)(H,41,56)(H,42,58)(H,43,49)(H,44,48)(H,45,55)(H,50,51)(H,52,53)(H,59,60)/t16-,17-,20-,22-,23-,24-/m0/s1 |
| InChI Key | ZRZROXNBKJAOKB-GFVHOAGBSA-N |
| Hazard Symbols | transportation |
| MSDS | msds/175269_1_62568_57_4.pdf |
| Bioactivity | δ-Sleep Inducing Peptide is a neuropeptide, with antioxidant and anxiolytic properties. Related Catalog Signaling Pathways >> Others >> Others Peptides Research Areas >> Neurological Disease In Vivo In rabbit infused with δ-Sleep Inducing Peptide (DSIP), the spindle activity is increased, and heart and respiration rate are moderately decreased. δ-Sleep Inducing Peptide (DSIP) may act as a programming modulator at supra-operational level rather than as a transmitter at operational level[1]. δ-Sleep Inducing Peptide (DSIP; 40 μg/kg, i.p.) increases catalase and superoxide dismutase (SOD) activities and malonic dialdehyde (MDA) concentration in the liver homogenate of rats subjected to acute stress, but the opposite effects are observed at 120, and 360 μg/kg[2]. Animal Admin Rats[2] Experiments are performed on male Wistar rats (n = 100) weighing 250-280 g. The animals are divided into groups (10 specimens per group). They are maintained under standard vivarium conditions and have free access to water and food (12:12-h light/dark regimen). δ-Sleep Inducing Peptide is dissolved in physiological saline and injected intraperitoneally 60 min before each stress exposure. Control animals receive an equivalent volume of physiological saline (1 mL/kg). The liver is homogenized in ice-cold physiological saline and centrifuged. The content of LPO products and activities of antioxidant enzymes are measured in the supernatant. LPO intensity is evaluated by malonic dialdehyde (MDA) concentration. Activities of superoxide dismutase (SOD) and catalase are measured spectrophotometrically. The total antioxidant activity (TAA) is evaluated by the method based on inhibition of ascorbate-induced and iron-induced oxidation of Tween-80 to MDA. The assay is conducted on a BTS-330 biochemical analyzer[2]. References [1]. Monnier M, et al. The delta sleep inducing peptide (DSIP). Comparative properties of the original and synthetic nonapeptide. Experientia. 1977 Apr 15;33(4):548-52. [2]. Bobyntsev II, et al. Effect of Delta Sleep-Inducing Peptide on Functional State of Hepatocytes in Rats During Restraint Stress. Bull Exp Biol Med. 2016 Feb;160(4):421-4. Chemical & Physical Properties Density 1.5±0.1 g/cm3 Boiling Point 1522.7±65.0 °C at 760 mmHg Molecular Formula C35H48N10O15 Molecular Weight 848.814 Flash Point 874.7±34.3 °C Exact Mass 848.330078 PSA 406.74000 LogP -3.57 Vapour Pressure 0.0±0.3 mmHg at 25°C Index of Refraction 1.612 InChIKey ZRZROXNBKJAOKB-GFVHOAGBSA-N SMILES CC(NC(=O)C(N)Cc1c[nH]c2ccccc12)C(=O)NCC(=O)NCC(=O)NC(CC(=O)O)C(=O)NC(C)C(=O)NC(CO)C(=O)NCC(=O)NC(CCC(=O)O)C(=O)O Storage condition −20°C Water Solubility Soluble in water at 0.5mg/ml |
| Use of | δ-Sleep Inducing Peptide is a neuropeptide, with antioxidant and anxiolytic properties. Properties Synonym More Synonyms Biological Activity Description δ-Sleep Inducing Peptide is a neuropeptide, with antioxidant and anxiolytic properties. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease In Vivo In rabbit infused with δ-Sleep Inducing Peptide (DSIP), the spindle activity is increased, and heart and respiration rate are moderately decreased. δ-Sleep Inducing Peptide (DSIP) may act as a programming modulator at supra-operational level rather than as a transmitter at operational level[1]. δ-Sleep Inducing Peptide (DSIP; 40 μg/kg, i.p.) increases catalase and superoxide dismutase (SOD) activities and malonic dialdehyde (MDA) concentration in the liver homogenate of rats subjected to acute stress, but the opposite effects are observed at 120, and 360 μg/kg[2]. References [1]. Monnier M, et al. The delta sleep inducing peptide (DSIP). Comparative properties of the original and synthetic nonapeptide. Experientia. 1977 Apr 15;33(4):548-52. [2]. Bobyntsev II, et al. Effect of Delta Sleep-Inducing Peptide on Functional State of Hepatocytes in Rats During Restraint Stress. Bull Exp Biol Med. 2016 Feb;160(4):421-4. Chemical & Physical Properties Molecular Formula C35H48N10O15 Exact Mass 848.330078 PSA 406.74000 LogP -3.57 Index of Refraction 1.612 InChIKey ZRZROXNBKJAOKB-GFVHOAGBSA-N |
| Transport Info | Product name: Purity: 97.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: No dangerous goods IMDG Code: No dangerous goods International Air Transport Dangerous Regulations: No dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special precautions for users No data available |
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