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Semax structure, CAS 80714-61-0

Semax

CAS Number80714-61-0

Synonyms1,3,5-tris[6-isocyanatohexyl]-2,4,6-trioxo-s-triazine; HMDI trimer; tris(6-isocyanatohexyl) isocyanurate; L-2-methylleucine methyl ester; 1,3,5-Tris(isocyanatohexamethylene)isocyanurate; Lys(Z)-OBzl.TosOH; H-MeLeu-OMe; hexamethylene diisocyanate isocyanurate; trimeric hexamethylene diisocyanate; H-Lys(Z)-OBzl*TosOH; H-Met-Glu-His-Phe-Pro-Gly-Pro; TsOH*H-Lys(Z)-OBzl; Desmodur N 3390 BA; Met-Glu-His-Phe-Pro-Gly-Pro

Molecular FormulaC37H51N9O10S

Molecular Weight813.92 (free base basis)

Purity≥98 (HPLC)%

Density1.391g/cm3

Boiling Point1335.2ºC at 760 mmHg

Melting Point

Flash Point

Appearancepowder

EINECS

MSDSChineseEnglish

Symboltransportation

Signal WordWarning

Cat. No.: 2A-0202372 Purity: ≥98 (HPLC)%
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Quality Control of [ 80714-61-0 ] Purity: ≥98 (HPLC)% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number80714-61-0
Catalog No.2A-0202372
Chinese Name脑力肽
Synonyms1,3,5-tris[6-isocyanatohexyl]-2,4,6-trioxo-s-triazine; HMDI trimer; tris(6-isocyanatohexyl) isocyanurate; L-2-methylleucine methyl ester; 1,3,5-Tris(isocyanatohexamethylene)isocyanurate; Lys(Z)-OBzl.TosOH; H-MeLeu-OMe; hexamethylene diisocyanate isocyanurate; trimeric hexamethylene diisocyanate; H-Lys(Z)-OBzl*TosOH; H-Met-Glu-His-Phe-Pro-Gly-Pro; TsOH*H-Lys(Z)-OBzl; Desmodur N 3390 BA; Met-Glu-His-Phe-Pro-Gly-Pro
Molecular FormulaC37H51N9O10S
Molecular Weight813.92 (free base basis)
Purity≥98 (HPLC)
Density1.391g/cm3
Boiling Point1335.2ºC at 760 mmHg
Appearancepowder
Storage Condition-20°C, sealed, dry
ApplicationMEHFPGP is a neuroprotective peptide. MEHFPGP can be used in stroke research[1][2].
PubChem ID329824612
MDL NumberMFCD04113563
SMILESOC(=O)C(F)(F)F.CSCC[C@H](N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc2ccccc2)C(=O)N3CCC[C@H]3C(=O)NCC(=O)N4CCC[C@H]4C(O)=O
InChI1S/C37H51N9O10S.C2HF3O2/c1-57-16-13-24(38)32(50)42-25(11-12-31(48)49)33(51)43-26(18-23-19-39-21-41-23)34(52)44-27(17-22-7-3-2-4-8-22)36(54)46-15-5-9-28(46)35(53)40-20-30(47)45-14-6-10-29(45)37(55)56;3-2(4,5)1(6)7/h2-4,7-8,19,21,24-29H,5-6,9-18,20,38H2,1H3,(H,39,41)(H,40,53)(H,42,50)(H,43,51)(H,44,52)(H,48,49)(H,55,56);(H,6,7)/t24-,25-,26-,27-,28-,29-;/m0./s1
InChI KeyUAXRUQRHZBYPHF-IGCYJKAMSA-N
NACRES CodeNA.32
UNSPSC51111800
Hazard Symbolstransportation
BioactivityMEHFPGP is a nootropic neuroprotective peptide. MEHFPGP can be used in the research of brain stroke[1][2]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease In Vitro MEHFPGP (25 μM and 100 μM, 48 h) reduces the Abeta oligomers (100 μM) levels[2]. MEHFPGP (100 nM) increase survival of cholinergic basal forebrain neurons[3]. MEHFPGP (100 nM) stimulates activity of choline acetyltransferase in dissociated basal forebrain tissue culture[3]. MEHFPGP (10 μM, 24 h) stimulates the synthesis of brain-derived neurotrophic factor (BDNF) in astrocytes cultured from rat basal forebrain[4]. In Vivo MEHFPGP (Semax, 100 μg/kg, i.p.) promotes the formation and functioning of the vascular system in Ischemia (pMCAO) rats[1]. MEHFPGP (50 µg and 250 µg, 100 µL/kg, intranasal inhalation) increases levels of b BDNF protein in rat basal forebrain[5]. Animal Model: Ischemia (pMCAO) rats[1]. Dosage: 100 μg/kg Administration: Intraperitoneal injections (i.p.), performed 15 min, 1, 4 and 8 h after permanent middle cerebral artery occlusion (pMCAO). Result: Increased the immune response (upregulation of transcripts). Animal Model: Rats[5] Dosage: 50 µg, 250 µg, 100 µL/kg Administration: Intranasal inhalation Result: Increased levels of brain-derived neurotrophic factor (BDNF) protein in rat basal forebrain. Chemical & Physical Properties Density 1.391g/cm3 Boiling Point 1335.2ºC at 760 mmHg Molecular Formula C37H51N9O10S Molecular Weight 813.92000 Flash Point 761.3ºC Exact Mass 813.34800 PSA 325.58000 LogP 2.71460 Index of Refraction 1.617 InChIKey AFEHBIGDWIGTEH-AQRCPPRCSA-N SMILES CSCCC(N)C(=O)NC(CCC(=O)O)C(=O)NC(Cc1cnc[nH]1)C(=O)NC(Cc1ccccc1)C(=O)N1CCCC1C(=O)NCC(=O)N1CCCC1C(=O)O
Use ofMEHFPGP is a nootropic neuroprotective peptide. MEHFPGP can be used in the research of brain stroke[1][2]. Properties Name L-Methionyl-L-α-glutamylhistidyl-L-phenylalanyl-L-prolylglycyl-L- proline Synonym More Synonyms Semax Biological Activity Description MEHFPGP is a nootropic neuroprotective peptide. MEHFPGP can be used in the research of brain stroke[1][2]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease In Vitro MEHFPGP (25 μM and 100 μM, 48 h) reduces the Abeta oligomers (100 μM) levels[2]. MEHFPGP (100 nM) increase survival of cholinergic basal forebrain neurons[3]. MEHFPGP (100 nM) stimulates activity of choline acetyltransferase in dissociated basal forebrain tissue culture[3]. MEHFPGP (10 μM, 24 h) stimulates the synthesis of brain-derived neurotrophic factor (BDNF) in astrocytes cultured from rat basal forebrain[4]. Chemical & Physical Properties Molecular Formula C37H51N9O10S Exact Mass 813.34800 PSA 325.58000 LogP 2.71460 Index of Refraction 1.617 InChIKey AFEHBIGDWIGTEH-AQRCPPRCSA-N
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip.
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