CAS Number80-08-0
SynonymsAradur 976-1; Seikacure S; 4,4'-Sulfonylbisbenzeneamine; Dapsone (USP); Dapsone; 1,1'-Sulfonylbis[4-aminobenzene]; ACZONE; 4-(4-aminophenyl)sulfonylaniline; EINECS 201-248-4; 4,4'-Sulfonyldianiline; Diaphenylsulfone (JAN); MFCD00007887; 4,4'-Diaminodiphenylsulfone; ZR DSWR DZ; 4-Aminophenylsulfone; Bis(p-aminophenyl)sulfone
Molecular Formula[4-(NH2)C6H4]2SO2
Molecular Weight248.30
Purity≥97.0 (HPLC)%
Density1.4±0.1 g/cm3
Boiling Point511.7±35.0 °C at 760 mmHg
Melting Point172-175 °C
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 80-08-0 |
| Catalog No. | 2A-9017294 |
| Chinese Name | 4,4'-二氨基二苯砜 |
| Synonyms | Aradur 976-1; Seikacure S; 4,4'-Sulfonylbisbenzeneamine; Dapsone (USP); Dapsone; 1,1'-Sulfonylbis[4-aminobenzene]; ACZONE; 4-(4-aminophenyl)sulfonylaniline; EINECS 201-248-4; 4,4'-Sulfonyldianiline; Diaphenylsulfone (JAN); MFCD00007887; 4,4'-Diaminodiphenylsulfone; ZR DSWR DZ; 4-Aminophenylsulfone; Bis(p-aminophenyl)sulfone |
| Molecular Formula | [4-(NH2)C6H4]2SO2 |
| Molecular Weight | 248.30 |
| Purity | ≥97.0 (HPLC) |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 511.7±35.0 °C at 760 mmHg |
| Melting Point | 172-175 °C |
| Appearance | powder |
| Water Solubility | <0.1 g/100 mL at 20 ºC |
| Storage Condition | This product should be sealed and stored away from |
| Packaging | III |
| Application | Dapsone can fight a variety of bacteria and is mainly used to fight Mycobacterium leprae. |
| HTC | 29309070 |
| MDL Number | MFCD00007887 |
| SMILES | [S](=O)(=O)(c2ccc(cc2)N)c1ccc(cc1)N |
| InChI | 1S/C12H12N2O2S/c13-9-1-5-11(6-2-9)17(15,16)12-7-3-10(14)4-8-12/h1-8H,13-14H2 |
| InChI Key | MQJKPEGWNLWLTK-UHFFFAOYSA-N |
| NACRES Code | NA.22 |
| UNSPSC | 12352116 |
| Hazard Symbols | 6.1(b) |
| MSDS | msds/17294_1_80_08_0.pdf |
| Bioactivity | Dapsone is a sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae.Target: AntibacterialDapsone is an antibacterial most commonly used in combination with rifampicin and clofazimine as multidrug therapy (MDT) for the treatment of Mycobacterium leprae infections (leprosy). Dapsone antagonized all of the I/R end points measured, showing a remarkable ability to decrease markers of damage through antioxidant, antiinflammatory, and anti-apoptotic effects [1]. As an antibacterial, dapsone inhibits bacterial synthesis of dihydrofolic acid, via competition with para-aminobenzoate for the active site of dihydropteroate synthetase. Dapsone has anti-inflammatory and immunomodulatory effects [2]. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [1]. Diaz-Ruiz, A., et al., Antioxidant, antiinflammatory and antiapoptotic effects of dapsone in a model of brain ischemia/reperfusion in rats. J Neurosci Res, 2008. 86(15): p. 3410-9. [2]. Begon, E., O. Chosidow, and P. Wolkenstein, [Disulone]. Ann Dermatol Venereol, 2004. 131(12): p. 1062-73. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 511.7±35.0 °C at 760 mmHg Melting Point 175-177 °C(lit.) Molecular Formula C12H12N2O2S Molecular Weight 248.301 Flash Point 263.2±25.9 °C Exact Mass 248.061951 PSA 94.56000 LogP 0.94 Vapour Pressure 0.0±1.3 mmHg at 25°C Index of Refraction 1.662 InChIKey MQJKPEGWNLWLTK-UHFFFAOYSA-N SMILES Nc1ccc(S(=O)(=O)c2ccc(N)cc2)cc1 Stability Stable. Combustible. Incompatible with strong oxidizing agents. Water Solubility <0.1 g/100 mL at 20 ºC |
| Use of | Dapsone is a sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae.Target: AntibacterialDapsone is an antibacterial most commonly used in combination with rifampicin and clofazimine as multidrug therapy (MDT) for the treatment of Mycobacterium leprae infections (leprosy). Dapsone antagonized all of the I/R end points measured, showing a remarkable ability to decrease markers of damage through antioxidant, antiinflammatory, and anti-apoptotic effects [1]. As an antibacterial, dapsone inhibits bacterial synthesis of dihydrofolic acid, via competition with para-aminobenzoate for the active site of dihydropteroate synthetase. Dapsone has anti-inflammatory and immunomodulatory effects [2]. Properties Articles96 Name dapsone Synonym More Synonyms 4,4'-Diaminodiphenylsulfone Biological Activity Description Dapsone is a sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae.Target: AntibacterialDapsone is an antibacterial most commonly used in combination with rifampicin and clofazimine as multidrug therapy (MDT) for the treatment of Mycobacterium leprae infections (leprosy). Dapsone antagonized all of the I/R end points measured, showing a remarkable ability to decrease markers of damage through antioxidant, antiinflammatory, and anti-apoptotic effects [1]. As an antibacterial, dapsone inhibits bacterial synthesis of dihydrofolic acid, via competition with para-aminobenzoate for the active site of dihydropteroate synthetase. Dapsone has anti-inflammatory and immunomodulatory effects [2]. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [1]. Diaz-Ruiz, A., et al., Antioxidant, antiinflammatory and antiapoptotic effects of dapsone in a model of brain ischemia/reperfusion in rats. J Neurosci Res, 2008. 86(15): p. 3410-9. [2]. Begon, E., O. Chosidow, and P. Wolkenstein, [Disulone]. Ann Dermatol Venereol, 2004. 131(12): p. 1062-73. Chemical & Physical Properties Molecular Formula C12H12N2O2S Exact Mass 248.061951 PSA 94.56000 Index of Refraction 1.662 InChIKey MQJKPEGWNLWLTK-UHFFFAOYSA-N Stability Stable. Combustible. Incompatible with strong oxidizing agents. |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Chemical name |
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