CAS Number644-78-0
Synonyms3-(2-hydroxyphenyl)-1-phenylprop-2-en-1-one; EINECS 211-422-1; MFCD00016449
Molecular FormulaC15H12O2
Molecular Weight224.25500
Density1.191g/cm3
Boiling Point396.566ºC at 760 mmHg
Melting Point144-150ºC(lit.)
AppearanceLight yellow-yellow green crystal-powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 644-78-0 |
| Catalog No. | 2A-1172291 |
| Chinese Name | 2-羟基查酮 |
| Synonyms | 3-(2-hydroxyphenyl)-1-phenylprop-2-en-1-one; EINECS 211-422-1; MFCD00016449 |
| Molecular Formula | C15H12O2 |
| Molecular Weight | 224.25500 |
| Density | 1.191g/cm3 |
| Boiling Point | 396.566ºC at 760 mmHg |
| Melting Point | 144-150ºC(lit.) |
| Appearance | Light yellow-yellow green crystal-powder |
| Storage Condition | Store in an airtight container in a cool, dry plac |
| Application | 2-hydroxychalcone is a natural flavonoid that is an antioxidant and inhibits lipid peroxidation. 2-hydroxychalcone induces apoptosis through downregulation of Bcl-2. 2-Hydroxychalcone inhibits the act |
| HTC | 2914501900 |
| PubChem ID | 93789 |
| SMILES | Oc1ccccc1\C=C\C(=O)c2ccccc2 |
| InChI | InChI=1S/C15H12O2/c16-14-9-5-4-8-13(14)10-11-15(17)12-6-2-1-3-7-12/h1-11,16H/b11-10+ |
| InChI Key | InChIKey=UDOOPSJCRMKSGL-ZHACJKMWSA-N |
| Bioactivity | 2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. 2-Hydroxychalcone induces apoptosis by Bcl-2 downregulation. 2-Hydroxychalcone inhibits the activation of NF-kB[1][2][3]. Related Catalog Signaling Pathways >> Apoptosis >> Bcl-2 Family Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Metabolic Disease In Vitro 2-Hydroxychalcone inhibits invasion of triple negative breast cancer cells[1]. 2-hydroxychalcone inhibits the adhesion of peripheral neutrophils to the endothelial cell monolayers by inhibiting the expression of ICAM-1, VCAM-1, and E-selectin in a concentration-dependent manner[2]. References [1]. Sun Young Kim, et al. 2-Hydroxychalcone and Xanthohumol Inhibit Invasion of Triple Negative Breast Cancer Cells. Chem Biol Interact. 2013 May 25;203(3):565-72. [2]. B Madan, et al. 2'-hydroxychalcone Inhibits Nuclear factor-kappaB and Blocks Tumor Necrosis Factor-Alpha- And Lipopolysaccharide-Induced Adhesion of Neutrophils to Human Umbilical Vein Endothelial Cells. Mol Pharmacol. 2000 Sep;58(3):526-34. [3]. BABITA MADAN, et al. 2-Hydroxychalcone Inhibits Nuclear Factor-kB and Blocks Tumor Necrosis Factor-a- and Lipopolysaccharide-Induced Adhesion of Neutrophils to Human Umbilical Vein Endothelial Cells. Mol Pharmacol 58:526-534, 2000. Chemical & Physical Properties Density 1.191g/cm3 Boiling Point 396.566ºC at 760 mmHg Melting Point 144-150ºC(lit.) Molecular Formula C15H12O2 Molecular Weight 224.25500 Flash Point 169.35ºC Exact Mass 224.08400 PSA 37.30000 LogP 3.28830 Index of Refraction 1.654 |
| Use of | 2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. 2-Hydroxychalcone induces apoptosis by Bcl-2 downregulation. 2-Hydroxychalcone inhibits the activation of NF-kB[1][2][3]. Properties Name 2-Hydroxychalcone Synonym More Synonyms 2-Hydroxychalcone Biological Activity Description 2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. 2-Hydroxychalcone induces apoptosis by Bcl-2 downregulation. 2-Hydroxychalcone inhibits the activation of NF-kB[1][2][3]. Related Catalog Signaling Pathways >> Apoptosis >> Bcl-2 Family Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Metabolic Disease In Vitro 2-Hydroxychalcone inhibits invasion of triple negative breast cancer cells[1]. 2-hydroxychalcone inhibits the adhesion of peripheral neutrophils to the endothelial cell monolayers by inhibiting the expression of ICAM-1, VCAM-1, and E-selectin in a concentration-dependent manner[2]. References [1]. Sun Young Kim, et al. 2-Hydroxychalcone and Xanthohumol Inhibit Invasion of Triple Negative Breast Cancer Cells. Chem Biol Interact. 2013 May 25;203(3):565-72. [2]. B Madan, et al. 2'-hydroxychalcone Inhibits Nuclear factor-kappaB and Blocks Tumor Necrosis Factor-Alpha- And Lipopolysaccharide-Induced Adhesion of Neutrophils to Human Umbilical Vein Endothelial Cells. Mol Pharmacol. 2000 Sep;58(3):526-34. [3]. BABITA MADAN, et al. 2-Hydroxychalcone Inhibits Nuclear Factor-kB and Blocks Tumor Necrosis Factor-a- and Lipopolysaccharide-Induced Adhesion of Neutrophils to Human Umbilical Vein Endothelial Cells. Mol Pharmacol 58:526-534, 2000. Chemical & Physical Properties Molecular Formula C15H12O2 Exact Mass 224.08400 PSA 37.30000 LogP 3.28830 Index of Refraction 1.654 |
| Tax Rebate | 9.0% |
| Supervision | none |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified 2-Hydroxychalcone |
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