| Chemical & Physical Properties | |
|---|---|
| CAS Number | 474-67-9 |
| Catalog No. | 2A-1172148 |
| Chinese Name | 菜籽甾醇 |
| Synonyms | EINECS 207-486-5; Ergosta-5,22-dien-3β-ol; (3β,22E)-Ergosta-5,22-dien-3-ol |
| Molecular Formula | C28H46O |
| Molecular Weight | 398.664 |
| Purity | 98.00 |
| Density | 1.0±0.1 g/cm3 |
| Boiling Point | 488.7±14.0 °C at 760 mmHg |
| Storage Condition | Store sealed at 2-8°C, placed in a ventilated, dry |
| Application | Brassinosterol is a metabolite of ergosterol and plays a role in inhibiting the development and promotion of bladder cancer through androgen signaling [1]. Brassinosterol has dual anti-infectious prop |
| PubChem ID | 11006 |
| SMILES | CC(C)C(C)C=CC(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C |
| InChI | InChI=1S/C28H46O/c1-18(2)19(3)7-8-20(4)24-11-12-25-23-10-9-21-17-22(29)13-15-27(21,5)26(23)14-16-28(24,25)6/h7-9,18-20,22-26,29H,10-17H2,1-6H3/b8-7+/t19-,20+,22-,23-,24+,25-,26-,27-,28+/m0/s1 |
| InChI Key | OILXMJHPFNGGTO-ZAUYPBDWSA-N |
| MSDS | msds/172372_2_474_67_9.pdf |
| Bioactivity | Brassicasterol, a metabolite of Ergosterol, plays a role in the inhibitory effect on bladder carcinogenesis promotion via androgen signaling[1]. Brassicasterol shows dual anti-infective properties against HSV-1 (IC50=1.2 µM) and Mycobacterium tuberculosis, and cardiovascular protective effect[2]. Brassicasterol exerts an anti-cancer effect by dual-targeting AKT and androgen receptor signaling in prostate cancer[3]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Anti-infection >> HSV Research Areas >> Infection Signaling Pathways >> Others >> Androgen Receptor Signaling Pathways >> Anti-infection >> Bacterial References [1]. Yasuharu Yazawa, et al. Inhibitory effect of ergosterol on bladder carcinogenesis is due to androgen signaling inhibition by brassicasterol, a metabolite of ergosterol. J Nat Med. 2020 Sep;74(4):680-688. [2]. Sherif T S Hassan. Brassicasterol with Dual Anti-Infective Properties against HSV-1 and Mycobacterium tuberculosis, and Cardiovascular Protective Effect: Nonclinical In Vitro and In Silico Assessments. Biomedicines. 2020 May 24;8(5):132. [3]. Yinzhu Xu, et al. Brassicasterol from Edible Aquacultural Hippocampus abdominalis Exerts an Anti-Cancer Effect by Dual-Targeting AKT and AR Signaling in Prostate Cancer. Biomedicines. 2020 Sep 22;8(9):370. Chemical & Physical Properties Density 1.0±0.1 g/cm3 Boiling Point 488.7±14.0 °C at 760 mmHg Molecular Formula C28H46O Molecular Weight 398.664 Flash Point 213.3±12.4 °C Exact Mass 398.354858 PSA 20.23000 LogP 9.68 Vapour Pressure 0.0±2.8 mmHg at 25°C Index of Refraction 1.532 InChIKey OILXMJHPFNGGTO-ZAUYPBDWSA-N SMILES CC(C)C(C)C=CC(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C Storage condition 2-8°C |
| Use of | Brassicasterol, a metabolite of Ergosterol, plays a role in the inhibitory effect on bladder carcinogenesis promotion via androgen signaling[1]. Brassicasterol shows dual anti-infective properties against HSV-1 (IC50=1.2 µM) and Mycobacterium tuberculosis, and cardiovascular protective effect[2]. Brassicasterol exerts an anti-cancer effect by dual-targeting AKT and androgen receptor signaling in prostate cancer[3]. Properties Name Brassicasterol Synonym More Synonyms Ergosta-5,22-dien-3β-ol Biological Activity Description Brassicasterol, a metabolite of Ergosterol, plays a role in the inhibitory effect on bladder carcinogenesis promotion via androgen signaling[1]. Brassicasterol shows dual anti-infective properties against HSV-1 (IC50=1.2 µM) and Mycobacterium tuberculosis, and cardiovascular protective effect[2]. Brassicasterol exerts an anti-cancer effect by dual-targeting AKT and androgen receptor signaling in prostate cancer[3]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Anti-infection >> HSV Research Areas >> Infection Signaling Pathways >> Others >> Androgen Receptor Signaling Pathways >> Anti-infection >> Bacterial References [1]. Yasuharu Yazawa, et al. Inhibitory effect of ergosterol on bladder carcinogenesis is due to androgen signaling inhibition by brassicasterol, a metabolite of ergosterol. J Nat Med. 2020 Sep;74(4):680-688. [2]. Sherif T S Hassan. Brassicasterol with Dual Anti-Infective Properties against HSV-1 and Mycobacterium tuberculosis, and Cardiovascular Protective Effect: Nonclinical In Vitro and In Silico Assessments. Biomedicines. 2020 May 24;8(5):132. [3]. Yinzhu Xu, et al. Brassicasterol from Edible Aquacultural Hippocampus abdominalis Exerts an Anti-Cancer Effect by Dual-Targeting AKT and AR Signaling in Prostate Cancer. Biomedicines. 2020 Sep 22;8(9):370. Chemical & Physical Properties Molecular Formula C28H46O Exact Mass 398.354858 PSA 20.23000 Index of Refraction 1.532 InChIKey OILXMJHPFNGGTO-ZAUYPBDWSA-N |
| Transport Info | Product name: Rapeseed sterol |
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