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Home > Products > Specialty & Industrial Chemicals > Specialty Chemicals > LOXOPROFEN SODIUM SALT
LOXOPROFEN SODIUM SALT structure, CAS 226721-96-6

LOXOPROFEN SODIUM SALT

CAS Number226721-96-6

Synonyms2-[4-[(2-Oxocyclopentyl)methyl]phenyl]propionic Acid Sodium Salt Dihydrate; Lobu; CS-600; Loxoprofen sodium hydrate; Oxeno; Loxoprofen sodium salt; Loxoprofen sodium dihydrate; Loxoprofen Sodium Salt Dihydrate

Molecular FormulaC15H21NaO5

Molecular Weight304.31400

Purity

Density

Boiling Point

Melting Point198 °C(dec.)

Flash Point

AppearanceSolid;White to Almost white powder to crystal

EINECS

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Symbol1.0

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Cat. No.: 2A-1172287 Purity:
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Quality Control of [ 226721-96-6 ] SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number226721-96-6
Catalog No.2A-1172287
Chinese Name洛索洛芬钠二水合物
Synonyms2-[4-[(2-Oxocyclopentyl)methyl]phenyl]propionic Acid Sodium Salt Dihydrate; Lobu; CS-600; Loxoprofen sodium hydrate; Oxeno; Loxoprofen sodium salt; Loxoprofen sodium dihydrate; Loxoprofen Sodium Salt Dihydrate
Molecular FormulaC15H21NaO5
Molecular Weight304.31400
Melting Point198 °C(dec.)
AppearanceSolid;White to Almost white powder to crystal
Storage Conditionroom temperature, dry
PackagingIII
ApplicationLoxoprofen sodium dihydrate is a non-steroidal orally active anti-inflammatory agent with analgesic and antipyretic properties. Loxoprofen sodium dihydrate is a non-selective COX inhibitor, with IC50s
PubChem ID7848772
SMILESCC(C(=O)[O-])c1ccc(CC2CCCC2=O)cc1.O.O.[Na+]
InChIInChI=1S/C15H18O3.Na.2H2O/c1-10(15(17)18)12-7-5-11(6-8-12)9-13-3-2-4-14(13)16;;;/h5-8,10,13H,2-4,9H2,1H3,(H,17,18);;2*1H2/q;+1;;/p-1
InChI KeyBAZQYVYVKYOAGO-UHFFFAOYSA-M
Hazard Symbols1.0
BioactivityLoxoprofen sodium dihydrate is a non-steroidal, orally active anti-inflammatory agent with analgesic and anti-pyretic properties. Loxoprofen sodium dihydrate is a nonselective COX inhibitor with IC50s of 6.5 and 13.5 μM for COX-1 and COX-2, respectively. Loxoprofen sodium dihydrate can reduce atherosclerosis and shows antitumor activity[1][2][3][4]. Related Catalog Research Areas >> Cancer Research Areas >> Cardiovascular Disease Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX Target COX-1:6.5 μM (IC50, in human whole blood) COX-2:13.5 μM (IC50, in human whole blood) In Vitro Loxoprofen sodium dihydrate, an anti-inflammatory prodrug (NSAID), is a nonselective COX inhibitor with IC50s of 6.5 and 13.5 μM for COX-1 and COX-2 in human whole blood assays, respectively[1]. Loxoprofen (LOX) sodium dihydrate is a non-selective cyclooxygenase inhibitor that is widely used for the reasearch of pain and inflammation caused by chronic and transitory conditions. Its alcoholic metabolites are formed by carbonyl reductase (CR) and they consist of trans-LOX, which is active, and cis-LOX, which is inactive. In addition, LOX sodium dihydrate can also be converted into an inactive hydroxylated metabolite (OH-LOXs) by cytochrome P450 (CYP)[2]. In Vivo Loxoprofen sodium (4 mg/kg/day; p.o.; 1 or 8 weeks) dihydrate reduces atherosclerosis in mice by reducing inflammation[3].Loxoprofen sodium (60 μg/mL; p.o.; 24 days) dihydrate suppresses mouse tumor growth by inhibiting VEGF[4]. Animal Model: ApoE-/- mice (C57BL/6J-Apoetm1Unc) with high-fat diet (0.2% cholesterol, 21% saturated fat) from 8 to 16 weeks of age[3] Dosage: 4 mg/kg/day in drinking water Administration: Oral dosing from 8 to 16 weeks of age or from 15 to 16 weeks of age Result: Inhibited platelet thromboxane production and platelet aggregation. Reduced extent of atherosclerosis. Suppressed the production of PGE2, TxB2 and PGI2. Animal Model: 6-week-old male C57BL/6 and BDF1 mice, 100 μL suspensions (2 × 106 cells/mL) of LLC cells and KLN205 cells were injected subcutaneously into C57BL/6 and BDF1 mice, respectively[4]. Dosage: 60 μg/mL Administration: Oral dosing in drinking water, every day for 24 days Result: Suppressed tumor growth and angiogenesis, suppressed expression of VEGF in mice with LLC tumor, inhibited tubular formation of HUVECs. References [1]. Riendeau D, et al. Evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2. Bioorg Med Chem Lett. 2004;14(5):1201-1203. [2]. Paudel S, et al. Assessing Drug Interaction and Pharmacokinetics of Loxoprofen in Mice Treated with CYP3A Modulators. Pharmaceutics. 2019;11(9):479. Published 2019 Sep 16. [3]. Hamaguchi M, et al. Loxoprofen Sodium, a Non-Selective NSAID, Reduces Atherosclerosis in Mice by Reducing Inflammation. J Clin Biochem Nutr. 2010 Sep;47(2):138-47. [4]. Kanda A, et al. Loxoprofen sodium suppresses mouse tumor growth by inhibiting vascular endothelial growth factor. Acta Oncol. 2003;42(1):62-70. Chemical & Physical Properties Melting Point 198 °C(dec.) Molecular Formula C15H21NaO5 Molecular Weight 304.31400 Exact Mass 304.12900 PSA 75.66000 LogP 1.32310 InChIKey BAZQYVYVKYOAGO-UHFFFAOYSA-M SMILES CC(C(=O)[O-])c1ccc(CC2CCCC2=O)cc1.O.O.[Na+]
Use ofLoxoprofen sodium dihydrate is a non-steroidal, orally active anti-inflammatory agent with analgesic and anti-pyretic properties. Loxoprofen sodium dihydrate is a nonselective COX inhibitor with IC50s of 6.5 and 13.5 μM for COX-1 and COX-2, respectively. Loxoprofen sodium dihydrate can reduce atherosclerosis and shows antitumor activity[1][2][3][4]. Properties Name sodium,2-[4-[(2-oxocyclopentyl)methyl]phenyl]propanoate,dihydrate Synonym More Synonyms LOXOPROFEN SODIUM SALT Biological Activity Description Loxoprofen sodium dihydrate is a non-steroidal, orally active anti-inflammatory agent with analgesic and anti-pyretic properties. Loxoprofen sodium dihydrate is a nonselective COX inhibitor with IC50s of 6.5 and 13.5 μM for COX-1 and COX-2, respectively. Loxoprofen sodium dihydrate can reduce atherosclerosis and shows antitumor activity[1][2][3][4]. Related Catalog Research Areas >> Cancer Research Areas >> Cardiovascular Disease Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX COX-1:6.5 μM (IC50, in human whole blood) COX-2:13.5 μM (IC50, in human whole blood) In Vitro Loxoprofen sodium dihydrate, an anti-inflammatory prodrug (NSAID), is a nonselective COX inhibitor with IC50s of 6.5 and 13.5 μM for COX-1 and COX-2 in human whole blood assays, respectively[1]. Loxoprofen (LOX) sodium dihydrate is a non-selective cyclooxygenase inhibitor that is widely used for the reasearch of pain and inflammation caused by chronic and transitory conditions. Its alcoholic metabolites are formed by carbonyl reductase (CR) and they consist of trans-LOX, which is active, and cis-LOX, which is inactive. In addition, LOX sodium dihydrate can also be converted into an inactive hydroxylated metabolite (OH-LOXs) by cytochrome P450 (CYP)[2]. References [1]. Riendeau D, et al. Evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2. Bioorg Med Chem Lett. 2004;14(5):1201-1203. [2]. Paudel S, et al. Assessing Drug Interaction and Pharmacokinetics of Loxoprofen in Mice Treated with CYP3A Modulators. Pharmaceutics. 2019;11(9):479. Published 2019 Sep 16. [3]. Hamaguchi M, et al. Loxoprofen Sodium, a Non-Selective NSAID, Reduces Atherosclerosis in Mice by Reducing Inflammation. J Clin Biochem Nutr. 2010 Sep;47(2):138-47. [4]. Kanda A, et al. Loxoprofen sodium suppresses mouse tumor growth by inhibiting vascular endothelial growth factor. Acta Oncol. 2003;42(1):62-70. Chemical & Physical Properties Molecular Formula C15H21NaO5 Exact Mass 304.12900 PSA 75.66000 LogP 1.32310 InChIKey BAZQYVYVKYOAGO-UHFFFAOYSA-M
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information United Nations classification: Item 1 Poisons. UN number: 2811 Proper Shipping Name: Toxic Solid, Organic, Not Otherwise Specified Packing grade: III
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