CAS Number18010-40-7
SynonymsMarcaina; Bupivacaine hydrochloride; Sensorcaine; Marcaine; Bupivacaine (hydrochloride); 2',6'-Pipecoloxylidide,1-butyl-,monohydrochloride; bupivacaine HCl; 1-Butyl-N-(2,6-dimethylphenyl)piperidin-2-carboxamidhydrochlorid; 1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide monohydrochloride; Einecs 241-917-8; Win 11318 HCl; Bupivacaine hydrochloride(Marcain); BUPIVACAINE HYDROCHLORIDE ANHYDROUS; UNII:AKA908P8J1; 1-butyl-N-(2,6-diméthylphényl)pipéridine-2-carboxamide chlorhydrate; bupivacaine monohydrochloride; 1-butyl-piperidine-2-carboxylic acid-(2,6-dimethyl-anilide),hydrochloride; Marcain; 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide hydrochloride; 1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide hydrochloride (1:1); 1-Butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxa
Molecular FormulaC18H29ClN2O
Molecular Weight324.889
Purity98%%
Boiling Point423.4ºC at 760 mmHg
Melting Point107.5 to 108ºC
AppearanceWhite-off-white crystal-powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 18010-40-7 |
| Catalog No. | 2A-1172238 |
| Chinese Name | 盐酸布比卡因 |
| Synonyms | Marcaina; Bupivacaine hydrochloride; Sensorcaine; Marcaine; Bupivacaine (hydrochloride); 2',6'-Pipecoloxylidide,1-butyl-,monohydrochloride; bupivacaine HCl; 1-Butyl-N-(2,6-dimethylphenyl)piperidin-2-carboxamidhydrochlorid; 1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide monohydrochloride; Einecs 241-917-8; Win 11318 HCl; Bupivacaine hydrochloride(Marcain); BUPIVACAINE HYDROCHLORIDE ANHYDROUS; UNII:AKA908P8J1; 1-butyl-N-(2,6-diméthylphényl)pipéridine-2-carboxamide chlorhydrate; bupivacaine monohydrochloride; 1-butyl-piperidine-2-carboxylic acid-(2,6-dimethyl-anilide),hydrochloride; Marcain; 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide hydrochloride; 1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide hydrochloride (1:1); 1-Butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxa |
| Molecular Formula | C18H29ClN2O |
| Molecular Weight | 324.889 |
| Purity | 98% |
| Boiling Point | 423.4ºC at 760 mmHg |
| Melting Point | 107.5 to 108ºC |
| Appearance | White-off-white crystal-powder |
| Storage Condition | 2-8°C |
| Packaging | II |
| Application | Bupivacaine hydrochloride is a local anesthetic compound. |
| PubChem ID | 556005 |
| SMILES | CCCCN1CCCCC1C(=O)Nc1c(C)cccc1C.Cl |
| InChI | InChI=1S/C18H28N2O.ClH/c1-4-5-12-20-13-7-6-11-16(20)18(21)19-17-14(2)9-8-10-15(17)3;/h8-10,16H,4-7,11-13H2,1-3H3,(H,19,21);1H |
| InChI Key | SIEYLFHKZGLBNX-UHFFFAOYSA-N |
| Bioactivity | Bupivacaine Hydrochloride is a local anaesthetic drug belonging to the amino amide group.Target: OthersBupivacaine hydrochloride is an effective local anesthetic agent. It has a rapid onset time, a high frequency of surgical anesthesia, a long duration, and a low incidence of side effects [1]. Median doses of bupivacaine (in milligrams per kilogram) producing asystole in protocol 1 were for 17.7 for saline, 27.6 for 10% Intralipid, 49.7 for 20% Intralipid, and 82.0 for 30% Intralipid (P < 0.001 for differences between all groups). Differences in mean ± SE concentrations of bupivacaine in plasma (in micrograms per milliliter) were significant (P < 0.05) for the difference between saline (93.3 ± 7.6) and 30% Intralipid (212 ± 45). In protocol 2, lipid infusion increased the dose of bupivacaine required to cause death in 50% of animals by 48%, from 12.5 to 18.5 mg/kg. The mean lipid:aqueous ratio of concentrations of bupivacaine in a plasma-Intralipid mixture was 11.9 ± 1.77 (n = 3) [2]. Related Catalog Signaling Pathways >> MAPK/ERK Pathway >> Ribosomal S6 Kinase (RSK) Research Areas >> Neurological Disease References [1]. Laskin, J.L., W.R. Wallace, and B. DeLeo, Use of bupivacaine hydrochloride in oral surgery-a clinical study. J Oral Surg, 1977. 35(1): p. 25-9. [2]. Weinberg, G.L., et al., Pretreatment or resuscitation with a lipid infusion shifts the dose-response to bupivacaine-induced asystole in rats. Anesthesiology, 1998. 88(4): p. 1071-5. Chemical & Physical Properties Boiling Point 423.4ºC at 760 mmHg Melting Point 107.5 to 108ºC Molecular Formula C18H29ClN2O Molecular Weight 324.889 Flash Point 209.9ºC Exact Mass 324.196838 PSA 32.34000 LogP 4.70940 InChIKey SIEYLFHKZGLBNX-UHFFFAOYSA-N SMILES CCCCN1CCCCC1C(=O)Nc1c(C)cccc1C.Cl Storage condition 2-8°C |
| Use of | Properties Articles46 Name bupivacaine hydrochloride (anhydrous) Synonym More Synonyms Bupivacaine hydrochloride Biological Activity Related Catalog Signaling Pathways >> MAPK/ERK Pathway >> Ribosomal S6 Kinase (RSK) Research Areas >> Neurological Disease References [1]. Laskin, J.L., W.R. Wallace, and B. DeLeo, Use of bupivacaine hydrochloride in oral surgery-a clinical study. J Oral Surg, 1977. 35(1): p. 25-9. [2]. Weinberg, G.L., et al., Pretreatment or resuscitation with a lipid infusion shifts the dose-response to bupivacaine-induced asystole in rats. Anesthesiology, 1998. 88(4): p. 1071-5. Chemical & Physical Properties Exact Mass 324.196838 PSA 32.34000 LogP 4.70940 InChIKey SIEYLFHKZGLBNX-UHFFFAOYSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: Item 1 Poisons. UN number: 2811 Proper Shipping Name: Toxic Solid, Organic, Not Otherwise Specified Packing grade: II |
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