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Flupyradifurone structure, CAS 951659-40-8

Flupyradifurone

CAS Number951659-40-8

Synonyms4-[(6-chloro-3-pyridylmethyl)(2,2-difluoroethyl)amino]furan-2(5H)-one; 4-{[(6-chloropyrid-3-yl)methyl](2,2-difluoro-ethyl)amino}furan-2(5H)-one; 4-{[(6-chloropyridin-3-yl)methyl](2,2-difluoroethyl)amino}furan-2(5H)-one; Flupyradifurone [ISO]; 4-{[(6-chloropyrid-3-yl)methyl](2,2-difluorethyl)amino}furan-2(5H)-one; 4-[[(6-chloro-3-pyridinyl)methyl](2,2-difluoroethyl)amino]-2(5H)-furanone; 3-[(6-chloropyridin-3-yl)-(2,2-difluoroethyl)amino]-2H-furan-5-one

Molecular FormulaC12H11ClF2N2O2

Molecular Weight288.67800

Purity

Density

Boiling Point

Melting Point69°C(lit.)

Flash Point

Appearancecrystallization

EINECS

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-1171652 Purity:
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Chemical & Physical Properties
CAS Number951659-40-8
Catalog No.2A-1171652
Chinese NameFlupyradifurone
Synonyms4-[(6-chloro-3-pyridylmethyl)(2,2-difluoroethyl)amino]furan-2(5H)-one; 4-{[(6-chloropyrid-3-yl)methyl](2,2-difluoro-ethyl)amino}furan-2(5H)-one; 4-{[(6-chloropyridin-3-yl)methyl](2,2-difluoroethyl)amino}furan-2(5H)-one; Flupyradifurone [ISO]; 4-{[(6-chloropyrid-3-yl)methyl](2,2-difluorethyl)amino}furan-2(5H)-one; 4-[[(6-chloro-3-pyridinyl)methyl](2,2-difluoroethyl)amino]-2(5H)-furanone; 3-[(6-chloropyridin-3-yl)-(2,2-difluoroethyl)amino]-2H-furan-5-one
Molecular FormulaC12H11ClF2N2O2
Molecular Weight288.67800
Melting Point69°C(lit.)
Appearancecrystallization
Storage Conditionroom temperature
ApplicationFluopyfuranone is a systemic nAChR agonist that can interfere with signal transduction in the central nervous system of sucking pests. Fluopyfuranone can be used as a butenolide insecticide [1].
PubChem ID26740989
SMILESO=C1C=C(N(Cc2ccc(Cl)nc2)CC(F)F)CO1
InChIInChI=1S/C12H11ClF2N2O2/c13-10-2-1-8(4-16-10)5-17(6-11(14)15)9-3-12(18)19-7-9/h1-4,11H,5-7H2
InChI KeyQOIYTRGFOFZNKF-UHFFFAOYSA-N
BioactivityFlupyradifurone is a systemic nAChR agonist that interferes with signal transduction in the central nervous system of sucking pests. Flupyradifurone can be used as a butenolide insecticide[1]. Related Catalog Research Areas >> Infection Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR In Vitro Flupyradifurone is a butenolide insecticide that activates insect nAChRs. Flupyradifurone is a butenolide insecticide and is considered friendly to honey bee fitness[1]. Flupyradifurone (FLF), an insecticide, compete with imidacloprid (IMI) for the same high affinity-binding site at the insect nAChR, the modulation of which leads to the toxic end point[2]. In Vivo The half-life of Flupyradifurone in peppers is 2.6-3.8 days. The national estimated daily intake of Flupyradifurone is 0.00094 mg/kg[3]. References [1]. Yi Guo, et al. The Effects of Exposure to Flupyradifurone on Survival, Development, and Foraging Activity of Honey Bees (Apis mellifera L.) under Field Conditions. Insects. 2021 Apr 16;12(4):357. [2]. Mark Montgomery, et al. Structural Biology-Guided Design, Synthesis, and Biological Evaluation of Novel Insect Nicotinic Acetylcholine Receptor Orthosteric Modulators. J Med Chem. 2022 Jan 5. [3]. Yizhi Feng, et al. Determination, residue analysis, dietary risk assessment, and processing of flupyradifurone and its metabolites in pepper under field conditions using LC-MS/MS. Biomed Chromatogr. 2022 Jan 3;e5312. Chemical & Physical Properties Melting Point 69°C(lit.) Molecular Formula C12H11ClF2N2O2 Molecular Weight 288.67800 Exact Mass 288.04800 PSA 42.43000 LogP 2.24280 InChIKey QOIYTRGFOFZNKF-UHFFFAOYSA-N SMILES O=C1C=C(N(Cc2ccc(Cl)nc2)CC(F)F)CO1
Use ofFlupyradifurone is a systemic nAChR agonist that interferes with signal transduction in the central nervous system of sucking pests. Flupyradifurone can be used as a butenolide insecticide[1]. Properties Name flupyradifurone Synonym More Synonyms Flupyradifurone Biological Activity Description Flupyradifurone is a systemic nAChR agonist that interferes with signal transduction in the central nervous system of sucking pests. Flupyradifurone can be used as a butenolide insecticide[1]. Related Catalog Research Areas >> Infection Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR In Vitro Flupyradifurone is a butenolide insecticide that activates insect nAChRs. Flupyradifurone is a butenolide insecticide and is considered friendly to honey bee fitness[1]. Flupyradifurone (FLF), an insecticide, compete with imidacloprid (IMI) for the same high affinity-binding site at the insect nAChR, the modulation of which leads to the toxic end point[2]. References [1]. Yi Guo, et al. The Effects of Exposure to Flupyradifurone on Survival, Development, and Foraging Activity of Honey Bees (Apis mellifera L.) under Field Conditions. Insects. 2021 Apr 16;12(4):357. [2]. Mark Montgomery, et al. Structural Biology-Guided Design, Synthesis, and Biological Evaluation of Novel Insect Nicotinic Acetylcholine Receptor Orthosteric Modulators. J Med Chem. 2022 Jan 5. [3]. Yizhi Feng, et al. Determination, residue analysis, dietary risk assessment, and processing of flupyradifurone and its metabolites in pepper under field conditions using LC-MS/MS. Biomed Chromatogr. 2022 Jan 3;e5312. Chemical & Physical Properties Exact Mass 288.04800 PSA 42.43000 LogP 2.24280 InChIKey QOIYTRGFOFZNKF-UHFFFAOYSA-N
Transport InfoProduct name: Fluopyfuranone
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