CAS Number77-60-1
SynonymsTIGOGENIN; Tsosarsasaprgein; (3β,5α,25R)-Spirostan-3-ol; MFCD00067287; Ticogenin; (25R)-5a-Spirostan-3b-ol; (25R)-5α-Spirostan-3β-ol; Sisalagenin; Trigonegenin B; EINECS 201-041-9
Molecular FormulaC27H44O3
Molecular Weight416.64
Purity≥90.0 (GC)%
Density1.1±0.1 g/cm3
Boiling Point516.6±20.0 °C at 760 mmHg
Melting Point202-204ºC
AppearanceWhite, microcrystalline powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 77-60-1 |
| Catalog No. | 2A-9017176 |
| Chinese Name | 剑麻皂苷元； 剑麻皂甙元； 剑麻皂素 |
| Synonyms | TIGOGENIN; Tsosarsasaprgein; (3β,5α,25R)-Spirostan-3-ol; MFCD00067287; Ticogenin; (25R)-5a-Spirostan-3b-ol; (25R)-5α-Spirostan-3β-ol; Sisalagenin; Trigonegenin B; EINECS 201-041-9 |
| Molecular Formula | C27H44O3 |
| Molecular Weight | 416.64 |
| Purity | ≥90.0 (GC) |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 516.6±20.0 °C at 760 mmHg |
| Melting Point | 202-204ºC |
| Appearance | White, microcrystalline powder |
| Storage Condition | Room Temperature |
| Application | Tigogenin is a steroidal saponin that is widely used in the synthesis of steroid drugs. Tigogenin inhibits adipocyte differentiation of mouse bone marrow stromal cells and induces osteoblast different |
| HTC | 2932999099 |
| MDL Number | MFCD00067287 |
| SMILES | C[C@@H]1CC[C@@]2(OC1)O[C@H]3C[C@H]4[C@@H]5CC[C@H]6C[C@@H](O)CC[C@]6(C)[C@H]5CC[C@]4(C)[C@H]3[C@@H]2C |
| InChI | 1S/C27H44O3/c1-16-7-12-27(29-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(28)8-10-25(18,3)21(20)9-11-26(22,24)4/h16-24,28H,5-15H2,1-4H3/t16-,17+,18+,19+,20-,21+,22+,23+,24+,25+,26+,27-/m1/s1 |
| InChI Key | GMBQZIIUCVWOCD-MFRNJXNGSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | 2.3 |
| MSDS | msds/17176_1_77_60_1.pdf |
| Use of | Tigogenin, one of steroidal sapogenins, is widely used for synthesizing steroid drugs. Tigogenin inhibits adipocytic differentiation and induces osteoblastic differentiation in mouse bone marrow stromal cells[1]. Properties Name (25R)-5.α.-Spirostan-3.β.-ol Synonym More Synonyms Tigogenin Biological Activity Description Tigogenin, one of steroidal sapogenins, is widely used for synthesizing steroid drugs. Tigogenin inhibits adipocytic differentiation and induces osteoblastic differentiation in mouse bone marrow stromal cells[1]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease References [1]. Zhou H, et al. Tigogenin inhibits adipocytic differentiation and induces osteoblastic differentiation in mouse bone marrow stromal cells. Mol Cell Endocrinol. 2007 May 30;270(1-2):17-22. Chemical & Physical Properties Molecular Formula C27H44O3 Exact Mass 416.329041 PSA 38.69000 Index of Refraction 1.552 InChIKey GMBQZIIUCVWOCD-MFRNJXNGSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 5-alpha-Spirostan-3-beta-ol, (25R)- CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C27-H44-O3 MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 29QKAZ "Toxins of Animal and Plant Origin, Proceedings International Symposium, 2nd, 1970," de Vries, A., and E. Kochva, eds., 3 vols., New York, Gordon and Breach Science Pub., 1971-73 Volume(issue)/page/year: 2,597,1972 Safety Information Hazard Codes Xi RTECS WH1443500 Hazard Class 2.3 HS Code 2932999099 Synthetic Route Literature: Williams, John R.; Gong, Hua; Hoff, Nathan; Olubodun, Olaoluwa I.; Carroll, Patrick J. Organic Letters, 2004 , vol. 6, # 2 p. 269 - 271 HECOGENIN ACETA... Literature: Upadhyay, Sunil Kumar; Creech, Clinton C.; Bowdy, Katharine L.; Stevens, Edwin D.; Jursic, Branko S.; Neumann, Donna M. Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 10 p. 2826 - 2831 (E)-1-(tert-but... 690275-05-9 Literature: Furrow, Michael E.; Myers, Andrew G. Journal of the American Chemical Society, 2004 , vol. 126, # 17 p. 5436 - 5445 Precursor & DownStream Precursor 5 CAS#:512-04-9 CAS#:915-35-5 HECOGENIN ACETATE CAS#:690275-05-9 (E)-1-(tert-but... CAS#:110124-76-0 (25R)-5α-spiros... DownStream 4 CAS#:17916-30-2 Pregn-5-en-20-o... CAS#:571-20-0 5α-Androstane-3... CAS#:1169-20-6 (3β,5α)-20-Oxop... CAS#:1239-31-2 Epiandrosterone... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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