CAS Number77-53-2
Synonyms8bH-Cedran-8-ol; EINECS 201-035-6; Cedarwood oil alcohols; (8α)-Cedran-8-ol; Cedar camphor; (1S,2R,5S,7R,8R)-2,6,6,8-Tetramethyltricyclo[5.3.1.0]undecan-8-ol; 8betaH-Cedran-8-ol; EUDESMOL; (1S,2R,5S,7R,8R)-2,6,6,8-Tétraméthyltricyclo[5.3.1.0]undécan-8-ol; Cypress camphor; 8βH-cedran-8-ol; [3R-(3a,3ab,6a,7b,8aa)]-Octahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulen-6-ol; Cedrol; MFCD00062952
Molecular FormulaC15H26O
Molecular Weight222.37
Purity≥99.0 (sum of enantiomers, GC)%
Density1.0±0.1 g/cm3
Boiling Point273 °C (lit.)
Melting Point82-86 °C
Appearancesolid
EINECS201-035-6
Symbol
Signal WordWarning
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| Chemical & Physical Properties | |
|---|---|
| CAS Number | 77-53-2 |
| Catalog No. | 2A-9017171 |
| Chinese Name | 柏木脑 |
| Synonyms | 8bH-Cedran-8-ol; EINECS 201-035-6; Cedarwood oil alcohols; (8α)-Cedran-8-ol; Cedar camphor; (1S,2R,5S,7R,8R)-2,6,6,8-Tetramethyltricyclo[5.3.1.0]undecan-8-ol; 8betaH-Cedran-8-ol; EUDESMOL; (1S,2R,5S,7R,8R)-2,6,6,8-Tétraméthyltricyclo[5.3.1.0]undécan-8-ol; Cypress camphor; 8βH-cedran-8-ol; [3R-(3a,3ab,6a,7b,8aa)]-Octahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulen-6-ol; Cedrol; MFCD00062952 |
| Molecular Formula | C15H26O |
| Molecular Weight | 222.37 |
| Purity | ≥99.0 (sum of enantiomers, GC) |
| Density | 1.0±0.1 g/cm3 |
| Boiling Point | 273 °C (lit.) |
| Melting Point | 82-86 °C |
| Appearance | solid |
| Water Solubility | Water solubility: insoluble; soluble in: chlorofor |
| Storage Condition | Storage, transportation and storage of tin cans, s |
| Application | Cedrol is a bioactive sesquiterpene and a potent competitive inhibitor of cytochrome P-450 (CYP) enzymes. Cedrol inhibits CYP2B6-mediated bupropion hydroxylase and CYP3A4-mediated hydroxylation of mid |
| EINECS | 201-035-6 |
| HTC | 2906199090 |
| PubChem ID | 57647965 |
| MDL Number | MFCD00062952 |
| SMILES | C[C@@H]1CC[C@H]2C(C)(C)[C@H]3C[C@@]12CC[C@@]3(C)O |
| InChI | 1S/C15H26O/c1-10-5-6-11-13(2,3)12-9-15(10,11)8-7-14(12,4)16/h10-12,16H,5-9H2,1-4H3/t10-,11+,12-,14-,15+/m1/s1 |
| InChI Key | SVURIXNDRWRAFU-OGMFBOKVSA-N |
| Beilstein/REAXYS | 2206347 |
| NACRES Code | NA.22 |
| UNSPSC | 12352212 |
| Hazard Symbols | Transport |
| MSDS | msds/17171_1_77_53_2.pdf |
| Bioactivity | Cedrol is a bioactive sesquiterpene, a potent competitive inhibitor of cytochrome P-450 (CYP) enzymes. Cedrol inhibits CYP2B6-mediated bupropion hydroxylase and CYP3A4-mediated midazolam hydroxylation with Ki of 0.9 μM and 3.4 μM, respectively. Cedrol also has weak inhibitory effect on CYP2C8, CYP2C9, and CYP2C19 enzymes[1]. Cedrol is found in cedar essential oil and poetesses anti-septic, anti-inflammatory, anti-spasmodic, tonic, astringent, diuretic, sedative, insecticidal, and anti-fungal activities[2]. Related Catalog Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Research Areas >> Inflammation/Immunology Target CYP2B6; CYP3A4; CYP2C8; CYP2C9; CYP2C19[1] References [1]. Jeong HU, et al. Inhibitory effects of cedrol, β-cedrene, and thujopsene on cytochrome P450 enzyme activities in human liver microsomes. J Toxicol Environ Health A. 2014;77(22-24):1522-32. [2]. Jin MH, et al. Cedrol Enhances Extracellular Matrix Production in Dermal Fibroblasts in a MAPK-Dependent Manner. Ann Dermatol. 2012 Feb;24(1):16-21 Chemical & Physical Properties Density 1.0±0.1 g/cm3 Boiling Point 277.2±8.0 °C at 760 mmHg Melting Point 55-59 °C(lit.) Molecular Formula C15H26O Molecular Weight 222.366 Flash Point 115.5±10.9 °C Exact Mass 222.198364 PSA 20.23000 LogP 4.77 Vapour Pressure 0.0±1.3 mmHg at 25°C Index of Refraction 1.519 InChIKey SVURIXNDRWRAFU-OGMFBOKVSA-N SMILES CC1CCC2C(C)(C)C3CC12CCC3(C)O |
| Use of | Properties Articles21 Name cedrol Synonym More Synonyms (+)-Cedrol Biological Activity Related Catalog Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Research Areas >> Inflammation/Immunology References [1]. Jeong HU, et al. Inhibitory effects of cedrol, β-cedrene, and thujopsene on cytochrome P450 enzyme activities in human liver microsomes. J Toxicol Environ Health A. 2014;77(22-24):1522-32. [2]. Jin MH, et al. Cedrol Enhances Extracellular Matrix Production in Dermal Fibroblasts in a MAPK-Dependent Manner. Ann Dermatol. 2012 Feb;24(1):16-21 Chemical & Physical Properties Molecular Formula C15H26O Exact Mass 222.198364 PSA 20.23000 Index of Refraction 1.519 InChIKey SVURIXNDRWRAFU-OGMFBOKVSA-N |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 5.5% Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 0.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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