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Home > Products > Pharmaceuticals & Life Science > Pharmaceutical Intermediates > 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1-(2,5-dioxo-1-pyrrolidinyl) ester
1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1-(2,5-dioxo-1-pyrrolidinyl) ester structure, CAS 170908-81-3

1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1-(2,5-dioxo-1-pyrrolidinyl) ester

CAS Number170908-81-3

Synonyms1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1-(2,5-dioxo-1-pyrrolidinyl) ester; 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid,1-(2,5-dioxo-1-pyrrolidinyl) ester

Molecular FormulaC20H31N5O10

Molecular Weight501.48800

Purity98.00%

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Cat. No.: 2A-1171546 Purity: 98.00%
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Quality Control of [ 170908-81-3 ] Purity: 98.00% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number170908-81-3
Catalog No.2A-1171546
Chinese Name1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸 1-(2,5-二氧代-1-吡咯烷基)酯
Synonyms1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1-(2,5-dioxo-1-pyrrolidinyl) ester; 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid,1-(2,5-dioxo-1-pyrrolidinyl) ester
Molecular FormulaC20H31N5O10
Molecular Weight501.48800
Purity98.00
Storage Conditionroom temperature, dry
ApplicationDOTA-NHS-ester is a cross-linker for affibody molecules that can be used in small animal positron emission tomography (PET), single photon emission computed tomography (SPECT) and CT scans. DOTA-NHS-e
HTC2933990090
PubChem ID16590629
SMILESO=C(O)CN1CCN(CC(=O)O)CCN(CC(=O)ON2C(=O)CCC2=O)CCN(CC(=O)O)CC1
InChIInChI=1S/C20H31N5O10/c26-15-1-2-16(27)25(15)35-20(34)14-24-9-7-22(12-18(30)31)5-3-21(11-17(28)29)4-6-23(8-10-24)13-19(32)33/h1-14H2,(H,28,29)(H,30,31)(H,32,33)
InChI KeyXSVWFLQICKPQAA-UHFFFAOYSA-N
Use ofDOTA-NHS-ester is a linker for affibody molecules and is applied in small animals PET, SPECT, and CT. DOTA-NHS-ester can be used to label radiotherapeutic agents or imaging probes for the detection of tumors[1]. Properties Name DOTA mono-N-hydroxysuccinimide ester Synonym More Synonyms DOTA-NHS-ester Biological Activity Description DOTA-NHS-ester is a linker for affibody molecules and is applied in small animals PET, SPECT, and CT. DOTA-NHS-ester can be used to label radiotherapeutic agents or imaging probes for the detection of tumors[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker References [1]. Hoppmann S, et al. Radiolabeled affibody-albumin bioconjugates for HER2-positive cancer targeting.Bioconjug Chem. 2011 Mar 16;22(3):413-2 Chemical & Physical Properties Molecular Formula C20H31N5O10 Exact Mass 501.20700 PSA 188.54000 InChIKey XSVWFLQICKPQAA-UHFFFAOYSA-N Safety Information Hazard Codes Xn HS Code 2933990090 Synthetic Route Total: 1 Page DOTA-tris(tBu)e... CAS#:819869-77-7 DOTA-NHS-ester CAS#:170908-81-3 Literature: Li, Cong; Winnard Jr., Paul T.; Takagi, Tomoyo; Artemov, Dmitri; Bhujwalla, Zaver M. Journal of the American Chemical Society, 2006 , vol. 128, # 47 p. 15072 - 15073 Precursor & DownStream Precursor 1 CAS#:819869-77-7 DOTA-tris(tBu)e... DownStream 0
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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