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Home > Products > Pharmaceuticals & Life Science > Pharmaceutical Intermediates > 2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide
2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide structure, CAS 883031-03-6

2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide

CAS Number883031-03-6

SynonymsHC-067047

Molecular FormulaC26H28F3N3O2

Molecular Weight471.51500

Purity98.00%

Density

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Cat. No.: 2A-1171537 Purity: 98.00%
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Quality Control of [ 883031-03-6 ] Purity: 98.00% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number883031-03-6
Catalog No.2A-1171537
Chinese NameHC-067047
SynonymsHC-067047
Molecular FormulaC26H28F3N3O2
Molecular Weight471.51500
Purity98.00
Storage Condition2-8℃
ApplicationHC-067047 is a potent and selective TRPV4 antagonist, with IC50s of 48 nM, 133 nM, and 17 nM for inhibiting human, rat, and mouse TRPV4 respectively.
PubChem ID3166908
SMILESCc1c(C(=O)Nc2cccc(C(F)(F)F)c2)cc(-c2ccccc2)n1CCCN1CCOCC1
InChIInChI=1S/C26H28F3N3O2/c1-19-23(25(33)30-22-10-5-9-21(17-22)26(27,28)29)18-24(20-7-3-2-4-8-20)32(19)12-6-11-31-13-15-34-16-14-31/h2-5,7-10,17-18H,6,11-16H2,1H3,(H,30,33)
InChI KeyNCZYSQOTAYFTNM-UHFFFAOYSA-N
Hazard Symbolstransportation
BioactivityHC-067047 is a potent and selective TRPV4 antagonist with IC50s of 48 nM, 133 nM, and 17 nM for human, rat, and mouse TRPV4. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Cancer Target IC50: 48 nM (human TRPV4), 133 nM (rat TRPV4), 17 nM (mouse TRPV4)[1] References [1]. Everaerts W et al. Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis.Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19084-9. Chemical & Physical Properties Molecular Formula C26H28F3N3O2 Molecular Weight 471.51500 Exact Mass 471.21300 PSA 49.99000 LogP 5.77880 InChIKey NCZYSQOTAYFTNM-UHFFFAOYSA-N SMILES Cc1c(C(=O)Nc2cccc(C(F)(F)F)c2)cc(-c2ccccc2)n1CCCN1CCOCC1 Storage condition 2-8℃
Use ofHC-067047 is a potent and selective TRPV4 antagonist with IC50s of 48 nM, 133 nM, and 17 nM for human, rat, and mouse TRPV4. Properties Name 2-methyl-1-(3-morpholin-4-ylpropyl)-5-phenyl-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamide Synonym More Synonyms HC 067047 Biological Activity Description HC-067047 is a potent and selective TRPV4 antagonist with IC50s of 48 nM, 133 nM, and 17 nM for human, rat, and mouse TRPV4. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Cancer IC50: 48 nM (human TRPV4), 133 nM (rat TRPV4), 17 nM (mouse TRPV4)[1] References [1]. Everaerts W et al. Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis.Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19084-9. Chemical & Physical Properties Molecular Formula C26H28F3N3O2 Exact Mass 471.21300 PSA 49.99000 LogP 5.77880 InChIKey NCZYSQOTAYFTNM-UHFFFAOYSA-N Storage condition 2-8℃
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 United Nations shipping name European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (2-methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-5- phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide) IMDG: TOXIC SOLID, ORGANIC, N.O.S. (2-methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-5- phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide) International air transport hazard regulations: Toxic solid, organic, n.o.s. (2-methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-5-phenyl-N-[3- (trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available
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