CAS Number1452-77-3
Synonymspyridine-2-carboxamide; Picolinamide; 2-Pyridinecarboxamide; 2-Pyridinecarboximidic acid; 2-PicolinaMide; EINECS 215-921-5; MFCD00023483
Molecular FormulaC6H6N2O
Molecular Weight122.125
Density1.2±0.1 g/cm3
Boiling Point257.7±32.0 °C at 760 mmHg
Melting Point110 °C (dec.)(lit.)
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1452-77-3 |
| Catalog No. | 2A-1171466 |
| Chinese Name | 吡啶酰胺 |
| Synonyms | pyridine-2-carboxamide; Picolinamide; 2-Pyridinecarboxamide; 2-Pyridinecarboximidic acid; 2-PicolinaMide; EINECS 215-921-5; MFCD00023483 |
| Molecular Formula | C6H6N2O |
| Molecular Weight | 122.125 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 257.7±32.0 °C at 760 mmHg |
| Melting Point | 110 °C (dec.)(lit.) |
| Storage Condition | Keep the container sealed and stored in a cool, dr |
| Application | Pyridinamide (2-pyridinamide) is an inhibitor of rat islet cell nuclear poly(ADP-ribose) synthase [1][3]. |
| HTC | 2933399090 |
| PubChem ID | 5053 |
| SMILES | NC(=O)c1ccccn1 |
| InChI | InChI=1S/C6H6N2O/c7-6(9)5-3-1-2-4-8-5/h1-4H,(H2,7,9) |
| InChI Key | IBBMAWULFFBRKK-UHFFFAOYSA-N |
| Hazard Symbols | transportation |
| MSDS | msds/171668_2_1452_77_3.pdf |
| Bioactivity | Picolinamide (2-Picolinamide) is an inhibitor of Poly(ADP-ribose) synthetase of nuclei from rat pancreatic islet cells[1][3]. Related Catalog Signaling Pathways >> Epigenetics >> PARP Research Areas >> Metabolic Disease Signaling Pathways >> Cell Cycle/DNA Damage >> PARP Target Poly(ADP-ribose) synthetase[1] In Vitro Picolinamide (10 μM-1 mM) inhibits Poly(ADP-ribose) synthetase activity[2]. Picolinamide (2 mM) protects against streptozotocin-induced depression of proinsulin synthesis in isolated pancreatic islets of rats[3]. In Vivo Picolinamide (4 mmol/kg, i.p., rats) inhibits Na+/phosphate cotransport by isolated renal brush border membrane vesicles[1]. Picolinamide (250 mg/kg, i.p., rats) enhances the tumorigenic effect of Streptozotocin and Alloxan on islet B-cells[4]. Animal Model: Rats[1] Dosage: 4 mmol/kg Administration: Intraperitoneal injection (i.p.) Result: Increased renal cortical NAD content (1.5 fold). References [1]. Campbell PI, et al. Specific inhibition of rat renal Na+/phosphate cotransport by picolinamide. J Pharmacol Exp Ther. 1989 Oct;251(1):188-92. [2]. Uchigata Y, et al. Protection by superoxide dismutase, catalase, and poly(ADP-ribose) synthetase inhibitors against alloxan- and streptozotocin-induced islet DNA strand breaks and against the inhibition of proinsulin synthesis. J Biol Chem. 1982 Jun 10;257(11):6084-8. [3]. Yamamoto H, et al. Protection by picolinamide, a novel inhibitor of poly (ADP-ribose) synthetase, against both streptozotocin-induced depression of proinsulin synthesis and reduction of NAD content in pancreatic islets. Biochem Biophys Res Commun. 1980 Jul 16;95(1):474-81. [4]. amagami T, et al. Induction of rat pancreatic B-cell tumors by the combined administration of streptozotocin or alloxan and poly(adenosine diphosphate ribose) synthetase inhibitors. Cancer Res. 1985 Apr;45(4):1845-9. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 257.7±32.0 °C at 760 mmHg Melting Point 110 °C (dec.)(lit.) Molecular Formula C6H6N2O Molecular Weight 122.125 Flash Point 109.7±25.1 °C Exact Mass 122.048012 PSA 55.98000 LogP -0.24 Vapour Pressure 0.0±0.6 mmHg at 25°C Index of Refraction 1.590 InChIKey IBBMAWULFFBRKK-UHFFFAOYSA-N SMILES NC(=O)c1ccccn1 |
| Use of | Picolinamide (2-Picolinamide) is an inhibitor of Poly(ADP-ribose) synthetase of nuclei from rat pancreatic islet cells[1][3]. Properties Articles35 Name picolinamide Synonym More Synonyms PYRIDINE-2-CARBOXAMIDE Biological Activity Description Picolinamide (2-Picolinamide) is an inhibitor of Poly(ADP-ribose) synthetase of nuclei from rat pancreatic islet cells[1][3]. Related Catalog Signaling Pathways >> Epigenetics >> PARP Research Areas >> Metabolic Disease Signaling Pathways >> Cell Cycle/DNA Damage >> PARP Poly(ADP-ribose) synthetase[1] References [1]. Campbell PI, et al. Specific inhibition of rat renal Na+/phosphate cotransport by picolinamide. J Pharmacol Exp Ther. 1989 Oct;251(1):188-92. [2]. Uchigata Y, et al. Protection by superoxide dismutase, catalase, and poly(ADP-ribose) synthetase inhibitors against alloxan- and streptozotocin-induced islet DNA strand breaks and against the inhibition of proinsulin synthesis. J Biol Chem. 1982 Jun 10;257(11):6084-8. [3]. Yamamoto H, et al. Protection by picolinamide, a novel inhibitor of poly (ADP-ribose) synthetase, against both streptozotocin-induced depression of proinsulin synthesis and reduction of NAD content in pancreatic islets. Biochem Biophys Res Commun. 1980 Jul 16;95(1):474-81. [4]. amagami T, et al. Induction of rat pancreatic B-cell tumors by the combined administration of streptozotocin or alloxan and poly(adenosine diphosphate ribose) synthetase inhibitors. Cancer Res. 1985 Apr;45(4):1845-9. Chemical & Physical Properties Molecular Formula C6H6N2O Exact Mass 122.048012 PSA 55.98000 LogP -0.24 Index of Refraction 1.590 InChIKey IBBMAWULFFBRKK-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: No dangerous goods IMDG Code: No dangerous goods International Air Transport Dangerous Regulations: No dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special precautions for users No data available |
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