CAS Number439239-90-4
SynonymsCOL-144; 2,4,6-trifluoro-N-[6-(1-methyl-piperidin-4-ylcarbonyl)-pyridin-2-yl]-benzamide; 2,4,6-Trifluoro-N-(6-(1-methylpiperidine-4-carbonyl)pyridin-2-yl)benzamide; Lasmiditan [INN]; 2,4,6-trifluoro-N-{6-[(1-methylpiperidin-4-yl)carbonyl]pyridin-2-yl}benzamide; 2,4,6-trifluoro-N-[6-(1-methyl-piperidin-4-ylcarbonyl)-pyridine-2-yl]-benzamide; 2,4,6-Trifluoro-N-{6-[(1-methyl-4-piperidinyl)carbonyl]-2-pyridinyl}benzamide; 2,4,6-trifluoro-N-(6-(1-methylpiperidine-4-carbonyl)pyridine-2-yl)benzamide; Lasmiditan (USAN/INN); lasmitidan; Lasmiditan
Molecular FormulaC19H18F3N3O2
Molecular Weight377.360
Purity98.00%%
Density1.4±0.1 g/cm3
Boiling Point433.3±45.0 °C at 760 mmHg
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 439239-90-4 |
| Catalog No. | 2A-1171037 |
| Chinese Name | 2,4,6-三氟-N-[6-[(1-甲基-4-哌啶基)羰基]-2-吡啶基]苯甲酰胺 |
| Synonyms | COL-144; 2,4,6-trifluoro-N-[6-(1-methyl-piperidin-4-ylcarbonyl)-pyridin-2-yl]-benzamide; 2,4,6-Trifluoro-N-(6-(1-methylpiperidine-4-carbonyl)pyridin-2-yl)benzamide; Lasmiditan [INN]; 2,4,6-trifluoro-N-{6-[(1-methylpiperidin-4-yl)carbonyl]pyridin-2-yl}benzamide; 2,4,6-trifluoro-N-[6-(1-methyl-piperidin-4-ylcarbonyl)-pyridine-2-yl]-benzamide; 2,4,6-Trifluoro-N-{6-[(1-methyl-4-piperidinyl)carbonyl]-2-pyridinyl}benzamide; 2,4,6-trifluoro-N-(6-(1-methylpiperidine-4-carbonyl)pyridine-2-yl)benzamide; Lasmiditan (USAN/INN); lasmitidan; Lasmiditan |
| Molecular Formula | C19H18F3N3O2 |
| Molecular Weight | 377.360 |
| Purity | 98.00% |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 433.3±45.0 °C at 760 mmHg |
| Storage Condition | 2-8℃ |
| Application | Lasmiditan (COL-144; LY573144) is a high-affinity 5-HT1F selective agonist with a Ki of 2.1 nM and a Ki of 1043 nM and 1357 nM for the 5-HT(1B) and 5-HT(1D) receptors, respectively. |
| HTC | 2933990090 |
| PubChem ID | 16713395 |
| SMILES | CN1CCC(C(=O)c2cccc(NC(=O)c3c(F)cc(F)cc3F)n2)CC1 |
| InChI | InChI=1S/C19H18F3N3O2/c1-25-7-5-11(6-8-25)18(26)15-3-2-4-16(23-15)24-19(27)17-13(21)9-12(20)10-14(17)22/h2-4,9-11H,5-8H2,1H3,(H,23,24,27) |
| InChI Key | XEDHVZKDSYZQBF-UHFFFAOYSA-N |
| Use of | Properties Name 2,4,6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)pyridin-2-yl]benzamide Synonym More Synonyms Lasmiditan Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Research Areas >> Neurological Disease References [1]. Nelson DL, et al. Preclinical pharmacological profile of the selective 5-HT1F receptor agonist lasmiditan. Cephalalgia. 2010 Oct;30(10):1159-69. [2]. Tfelt-Hansen PC, et al. The 5-HT1F receptor agonist lasmiditan as a potential treatment of migraine attacks: a review of two placebo-controlled phase II trials. J Headache Pain. 2012 Jun;13(4):271-5. Chemical & Physical Properties Molecular Formula C19H18F3N3O2 Exact Mass 377.135101 PSA 62.30000 Index of Refraction 1.585 InChIKey XEDHVZKDSYZQBF-UHFFFAOYSA-N Storage condition 2-8℃ Safety Information HS Code 2933990090 Synthetic Route Total: 1 Page (6-AMINOPYRIDIN... CAS#:613678-03-8 2,4,6-Trifluoro... CAS#:79538-29-7 Lasmiditan CAS#:439239-90-4 Precursor & DownStream Precursor 2 CAS#:613678-03-8 (6-AMINOPYRIDIN... CAS#:79538-29-7 2,4,6-Trifluoro... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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