CAS Number888216-25-9
SynonymsGanetespib (USAN); Ganetespib; Ganetespib,STA-9090; 5-(2,4-Dihydroxy-5-isopropylphenyl)-4-(1-methyl-1H-indol-5-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one; STA9090; STA-9090; UNII-2E8412Y946; Ganetespib [USAN:INN]
Molecular FormulaC20H20N4O3
Molecular Weight364.398
Purity98%%
Density1.4±0.1 g/cm3
Boiling Point685.8±57.0 °C at 760 mmHg
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 888216-25-9 |
| Catalog No. | 2A-1170963 |
| Chinese Name | 的ganetespib |
| Synonyms | Ganetespib (USAN); Ganetespib; Ganetespib,STA-9090; 5-(2,4-Dihydroxy-5-isopropylphenyl)-4-(1-methyl-1H-indol-5-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one; STA9090; STA-9090; UNII-2E8412Y946; Ganetespib [USAN:INN] |
| Molecular Formula | C20H20N4O3 |
| Molecular Weight | 364.398 |
| Purity | 98% |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 685.8±57.0 °C at 760 mmHg |
| Appearance | powder |
| Storage Condition | -20℃ |
| Application | Ganetespib is a heat shock protein 90 (HSP90) inhibitor that exhibits potent cytotoxicity in multiple hematological and solid tumor cell lines. |
| HTC | 2933990090 |
| PubChem ID | 46484925 |
| SMILES | CC(C)c1cc(-c2n[nH]c(=O)n2-c2ccc3c(ccn3C)c2)c(O)cc1O |
| InChI | InChI=1S/C20H20N4O3/c1-11(2)14-9-15(18(26)10-17(14)25)19-21-22-20(27)24(19)13-4-5-16-12(8-13)6-7-23(16)3/h4-11,25-26H,1-3H3,(H,22,27) |
| InChI Key | RVAQIUULWULRNW-UHFFFAOYSA-N |
| Use of | Ganetespib is a heat shock protein 90 (HSP90) inhibitor which exhibits potent cytotoxicity in a wide variety of hematological and solid tumor cell lines. Properties Name (5Z)-5-(4-hydroxy-6-oxo-3-propan-2-ylcyclohexa-2,4-dien-1-ylidene)-4-(1-methylindol-5-yl)-1,2,4-triazolidin-3-one Synonym More Synonyms Ganetespib(STA-9090) Biological Activity Description Ganetespib is a heat shock protein 90 (HSP90) inhibitor which exhibits potent cytotoxicity in a wide variety of hematological and solid tumor cell lines. Related Catalog Signaling Pathways >> Cell Cycle/DNA Damage >> HSP Signaling Pathways >> Metabolic Enzyme/Protease >> HSP Research Areas >> Cancer References [1]. Shimamura T, et al. Ganetespib (STA-9090), a Non-Geldanamycin HSP90 Inhibitor, has Potent Antitumor Activity in In Vitro and In Vivo Models of Non-Small Cell Lung Cancer. Clin Cancer Res. 2012 Jul 17. [2]. Ying W, et al. Ganetespib, a unique triazolone-containing Hsp90 inhibitor, exhibits potent antitumor activity and a superior safety profile for cancer therapy. Mol Cancer Ther. 2012 Feb;11(2):475-84. [3]. London CA, et al. Phase I evaluation of STA-1474, a prodrug of the novel HSP90 inhibitor ganetespib, in dogs with spontaneous cancer.PLoS One. 2011;6(11):e27018. [4]. Proia DA, et al. Multifaceted intervention by the Hsp90 inhibitor ganetespib (STA-9090) in cancer cells with activated JAK/STAT signaling. PLoS One. 2011 Apr 14;6(4):e18552. [5]. Stewart E, et al. Identification of Therapeutic Targets in Rhabdomyosarcoma through Integrated Genomic, Epigenomic, and Proteomic Analyses. Cancer Cell. 2018 Sep 10;34(3):411-426.e19. Chemical & Physical Properties Molecular Formula C20H20N4O3 Exact Mass 364.153534 PSA 96.33000 Index of Refraction 1.698 InChIKey RVAQIUULWULRNW-UHFFFAOYSA-N Storage condition -20℃ Safety Information HS Code 2933990090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| KRN 633 | 286370-15-8 | 2A-1170957 |
| TRV-130 | 1401031-39-7 | 2A-1170958 |
| UNC0379 | 1620401-82-2 | 2A-1170959 |
| T-1095 | 209746-59-8 | 2A-1170960 |
| Temozolomideacid | 113942-30-6 | 2A-1170961 |
| (E)-3-(3-bromo-4,5-dihydroxyphenyl)-N-(3,4,5-trihydroxybenzyl)prop-2-enethioamide | 1384426-12-3 | 2A-1170964 |
| AMG 925 | 1401033-86-0 | 2A-1170965 |
| AMG319 | 1608125-21-8 | 2A-1170966 |
| 1-(4-(5-(5-amino-6-(5-(tert-butyl)-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1H-1,2,4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-one | 1620576-64-8 | 2A-1170967 |
| IMISOPASEM MANGANESE | 218791-21-0 | 2A-1170969 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS