CAS Number61135-33-9
Synonyms5-ethynyl-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione; 5-Ethynyl-2'-deoxyuridine
Molecular FormulaC11H12N2O5
Molecular Weight252.22300
Density1.55g/cm3
Melting Point199 °C
AppearanceSolid;White to Orange to Green powder to crystal
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 61135-33-9 |
| Catalog No. | 2A-1170802 |
| Chinese Name | 5-乙炔基-2'-脱氧尿苷 |
| Synonyms | 5-ethynyl-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione; 5-Ethynyl-2'-deoxyuridine |
| Molecular Formula | C11H12N2O5 |
| Molecular Weight | 252.22300 |
| Density | 1.55g/cm3 |
| Melting Point | 199 °C |
| Appearance | Solid;White to Orange to Green powder to crystal |
| Storage Condition | 2~8℃, sealed, dry |
| Application | 5-Ethynyl-2'-deoxyuridine is a PROTAC linker and belongs to the alkyl chain class. Can be used to synthesize PROTAC molecules. |
| PubChem ID | 627678 |
| SMILES | C#Cc1cn(C2CC(O)C(CO)O2)c(=O)[nH]c1=O |
| InChI | InChI=1S/C11H12N2O5/c1-2-6-4-13(11(17)12-10(6)16)9-3-7(15)8(5-14)18-9/h1,4,7-9,14-15H,3,5H2,(H,12,16,17)/t7-,8+,9+/m0/s1 |
| InChI Key | CDEURGJCGCHYFH-DJLDLDEBSA-N |
| Hazard Symbols | transportation |
| Bioactivity | 5-Ethynyl-2'-deoxyuridine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker Target Alkyl-Chain In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. References [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 Chemical & Physical Properties Density 1.55g/cm3 Melting Point 199 °C Molecular Formula C11H12N2O5 Molecular Weight 252.22300 Exact Mass 252.07500 PSA 104.55000 Index of Refraction 1.644 InChIKey CDEURGJCGCHYFH-DJLDLDEBSA-N SMILES C#Cc1cn(C2CC(O)C(CO)O2)c(=O)[nH]c1=O |
| Use of | 5-Ethynyl-2'-deoxyuridine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Properties Articles66 Name 5-Ethynyl-2′-deoxyuridine, (EdU) Synonym More Synonyms 5-Ethynyl-2'-deoxyuridine Biological Activity Description 5-Ethynyl-2'-deoxyuridine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker Alkyl-Chain In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. References [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 Chemical & Physical Properties Molecular Formula C11H12N2O5 Exact Mass 252.07500 PSA 104.55000 Index of Refraction 1.644 InChIKey CDEURGJCGCHYFH-DJLDLDEBSA-N |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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