| Chemical & Physical Properties | |
|---|---|
| CAS Number | 5452-87-9 |
| Catalog No. | 2A-1170704 |
| Chinese Name | N-甲基-N,N-双(2-吡啶基乙基)胺 |
| Synonyms | N-methyl-2-pyridin-2-yl-N-(2-pyridin-2-ylethyl)ethanamine; NSC19005 |
| Molecular Formula | C15H19N3 |
| Molecular Weight | 241.33100 |
| Purity | 98% |
| Density | 1.067g/cm3 |
| Boiling Point | 371.9ºC at 760mmHg |
| Appearance | light yellow solid |
| Storage Condition | -20℃ |
| Application | Betahistine EP Impurity C (NSC19005) is an impurity of Betahistine. Betahistine is an orally active histamine H1 receptor agonist and H3 receptor antagonist studied in rheumatoid arthritis (RA). |
| HTC | 2933399090 |
| PubChem ID | 81958 |
| SMILES | CN(CCc1ccccn1)CCc1ccccn1 |
| InChI | InChI=1S/C15H19N3/c1-18(12-8-14-6-2-4-10-16-14)13-9-15-7-3-5-11-17-15/h2-7,10-11H,8-9,12-13H2,1H3 |
| InChI Key | PQHKIDBZBKQYMR-UHFFFAOYSA-N |
| Use of | Betahistine EP Impurity C (NSC19005) is an impurity of Betahistine[1]. Betahistine is a potent, orally active and well-tolerated histamine H1 receptor agonist and H3 receptor antagonist used for the study of rheumatoid arthritis (RA)[2][3]. Properties Name N-Methyl-N,N-bis(2-pyridylethyl)amine Synonym More Synonyms Betahistine EP Impurity C Biological Activity Description Betahistine EP Impurity C (NSC19005) is an impurity of Betahistine[1]. Betahistine is a potent, orally active and well-tolerated histamine H1 receptor agonist and H3 receptor antagonist used for the study of rheumatoid arthritis (RA)[2][3]. Related Catalog Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Histamine Receptor In Vitro Betahistine (0-10 μM) inhibits [125I]iodoproxyfan binding to membranes of CHO (rH3(445)R) and CHO (hH3(445)R) cells with IC50 values of 1.9 μM and 3.3 μM, respectively. Lead to Ki values of 1.4 μM and 2.5 μM, respectively[3]. References [1]. Murilo B. M. de Mello, et al. Characterization and in silico Mutagenic Assessment of a New Betahistine Degradation Impurity. J. Braz. Chem. Soc. vol.30 no.7 São Paulo July 2019 Epub July 04, 2019 [2]. Poyurovsky M, et al. The effect of betahistine, a histamine H1 receptor agonist/H3 antagonist, on olanzapine-induced weight gain in first-episode schizophrenia patients. Int Clin Psychopharmacol. 2005 Mar;20(2):101-3. [3]. Betahistine EP Impurity C (NSC19005) is an impurity of Betahistine[1]. Betahistine is a potent, orally active and well-tolerated histamine H1 receptor agonist and H3 receptor antagonist used for the study of rheumatoid arthritis (RA)[2]. Chemical & Physical Properties Molecular Formula C15H19N3 Exact Mass 241.15800 PSA 29.02000 LogP 2.19360 Index of Refraction 1.568 InChIKey PQHKIDBZBKQYMR-UHFFFAOYSA-N Storage condition -20℃ Safety Information HS Code 2933399090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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