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Home > Products > Specialty & Industrial Chemicals > Specialty Chemicals > COPROPORPHYRIN III DIHYDROCHLORIDE
COPROPORPHYRIN III DIHYDROCHLORIDE structure, CAS 14643-66-4

COPROPORPHYRIN III DIHYDROCHLORIDE

CAS Number14643-66-4

Synonyms3,3',3'',3'''-(3,8,13,17-tetramethyl-porphyrin-2,7,12,18-tetrayl)-tetra-propionic acid; COPROPORPHYRIN III DIHYDROCHLORIDE; 3,3',3'',3'''-(3,8,13,17-Tetramethyl-porphyrin-2,7,12,18-tetrayl)-tetra-propionsaeure; 3,3',3'',3'''-(3,8,13,17-tetramethyl-21H,23H-porphine-2,7,12,18-tetrayl)-tetrakis-propionic acid; CoproporphyrinIII Dihyrochloride; 2,7,12,18-Tetramethyl-21H,23H-porphyrin-3,8,13,17-tetrapropionic acid; coproporphyrin; Coproporphyrin III; Coproporphyrin dihydrochloride; coproporphyriniii2HCl; 3,8,13,17-tetramethylporphyrin-2,7,12,18-tetrapropanoic acid; 3,8,13,17-TETRAMETHYL-21H,23H-PORPHINE-2,7,12,18-TETRAPROPIONIC ACID DIHYDROCHLORIDE; Koproporphyrin III

Molecular FormulaC36H38N4O8

Molecular Weight654.71

Purity98.00%

Density1.366 g/cm3

Boiling Point1258ºC at 760 mmHg

Melting Point

Flash Point

Appearancepurple crystal

EINECS

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Symbol

Signal Word

Cat. No.: 2A-1170701 Purity: 98.00%
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Quality Control of [ 14643-66-4 ] Purity: 98.00% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number14643-66-4
Catalog No.2A-1170701
Chinese Name粪卟啉III二盐酸盐
Synonyms3,3',3'',3'''-(3,8,13,17-tetramethyl-porphyrin-2,7,12,18-tetrayl)-tetra-propionic acid; COPROPORPHYRIN III DIHYDROCHLORIDE; 3,3',3'',3'''-(3,8,13,17-Tetramethyl-porphyrin-2,7,12,18-tetrayl)-tetra-propionsaeure; 3,3',3'',3'''-(3,8,13,17-tetramethyl-21H,23H-porphine-2,7,12,18-tetrayl)-tetrakis-propionic acid; CoproporphyrinIII Dihyrochloride; 2,7,12,18-Tetramethyl-21H,23H-porphyrin-3,8,13,17-tetrapropionic acid; coproporphyrin; Coproporphyrin III; Coproporphyrin dihydrochloride; coproporphyriniii2HCl; 3,8,13,17-tetramethylporphyrin-2,7,12,18-tetrapropanoic acid; 3,8,13,17-TETRAMETHYL-21H,23H-PORPHINE-2,7,12,18-TETRAPROPIONIC ACID DIHYDROCHLORIDE; Koproporphyrin III
Molecular FormulaC36H38N4O8
Molecular Weight654.71
Purity98.00
Density1.366 g/cm3
Boiling Point1258ºC at 760 mmHg
Appearancepurple crystal
Storage Condition2-8℃
ApplicationCoproporphyrin III is a porphyrin derivative.
PubChem ID8065
SMILESCC1=C(CCC(=O)O)c2cc3nc(cc4[nH]c(cc5[nH]c(cc1n2)c(C)c5CCC(=O)O)c(CCC(=O)O)c4C)C(CCC(=O)O)=C3C
InChIInChI=1S/C36H38N4O8.2ClH/c1-17-21(5-9-33(41)42)29-14-27-19(3)22(6-10-34(43)44)30(39-27)15-28-20(4)24(8-12-36(47)48)32(40-28)16-31-23(7-11-35(45)46)18(2)26(38-31)13-25(17)37-29;;/h13-16,38,40H,5-12H2,1-4H3,(H,41,42)(H,43,44)(H,45,46)(H,47,48);2*1H
InChI KeyXNBNKCLBGTWWSD-UHFFFAOYSA-N
BioactivityCoproporphyrin III is a porphyrin derivative. Related Catalog Research Areas >> Others Natural Products >> Others Target Human Endogenous Metabolite In Vitro Coproporphyrin III methyl ester is repeatedly isolated in considerable amount from both feces and urine. A great increase of coproporphyrin III excretion is unaccompanied by symptoms or signs of porphyria, metal or chemical poisoning or liver disease[1]. Primary cultures of chick embryo hepatocytes have been used to study the mechanism by which chemicals cause accumulation of intermediates of the heme synthetic pathway. In the presence of the porphyrin precursor, 5-aminolevulinate (ALA), addition of insulin causes a striking increase in accumulation of uroporphyrin I and coproporphyrin III. Antioxidants abolishes the uroporphyrin I accumulation and increases coproporphyrin III[2]. In Vivo Urinary DMA and porphyrin profile can be used as an early warning biomarker for chronic MMA exposure before the onset of cancer. After 4 weeks the level of coproporphyrin III concentration significantly increases in all the treatment groups compared to the control[3]. References [1]. Watson CJ, et al. Studies of coproporphyrin. iii. idiopathic coproporphyrinuria; a hitherto unrecognized form characterized by lack of symptoms in spite of the excretion of large amounts of coproporphyrin. J Clin Invest. 1949 May;28(3):465-8. [2]. Trask HW, et al. Effect of insulin and glucagon on accumulation of uroporphyrin and coproporphyrin from 5-aminolevulinate in hepatocyte cultures. Arch Biochem Biophys. 2005 Jul 1;439(1):1-11. [3]. Krishnamohan M, et al. Urinary arsenic and porphyrin profile in C57BL/6J mice chronically exposed to monomethylarsonous acid (MMAIII) for two years. Toxicol Appl Pharmacol. 2007 Oct 1;224(1):89-97. Chemical & Physical Properties Density 1.366 g/cm3 Boiling Point 1258ºC at 760 mmHg Molecular Formula C36H38N4O8 Molecular Weight 654.71 Flash Point 714.6ºC PSA 205.50000 LogP 4.69760 Vapour Pressure 0mmHg at 25°C Index of Refraction 1.638 InChIKey XNBNKCLBGTWWSD-UHFFFAOYSA-N SMILES CC1=C(CCC(=O)O)c2cc3nc(cc4[nH]c(cc5[nH]c(cc1n2)c(C)c5CCC(=O)O)c(CCC(=O)O)c4C)C(CCC(=O)O)=C3C Storage condition 2-8℃
Use ofCoproporphyrin III is a porphyrin derivative. Properties Name coproporphyrin III Synonym More Synonyms Coproporphyrin III Biological Activity Description Coproporphyrin III is a porphyrin derivative. Related Catalog Research Areas >> Others Natural Products >> Others Human Endogenous Metabolite In Vitro Coproporphyrin III methyl ester is repeatedly isolated in considerable amount from both feces and urine. A great increase of coproporphyrin III excretion is unaccompanied by symptoms or signs of porphyria, metal or chemical poisoning or liver disease[1]. Primary cultures of chick embryo hepatocytes have been used to study the mechanism by which chemicals cause accumulation of intermediates of the heme synthetic pathway. In the presence of the porphyrin precursor, 5-aminolevulinate (ALA), addition of insulin causes a striking increase in accumulation of uroporphyrin I and coproporphyrin III. Antioxidants abolishes the uroporphyrin I accumulation and increases coproporphyrin III[2]. In Vivo Urinary DMA and porphyrin profile can be used as an early warning biomarker for chronic MMA exposure before the onset of cancer. After 4 weeks the level of coproporphyrin III concentration significantly increases in all the treatment groups compared to the control[3]. References [1]. Watson CJ, et al. Studies of coproporphyrin. iii. idiopathic coproporphyrinuria; a hitherto unrecognized form characterized by lack of symptoms in spite of the excretion of large amounts of coproporphyrin. J Clin Invest. 1949 May;28(3):465-8. [2]. Trask HW, et al. Effect of insulin and glucagon on accumulation of uroporphyrin and coproporphyrin from 5-aminolevulinate in hepatocyte cultures. Arch Biochem Biophys. 2005 Jul 1;439(1):1-11. [3]. Krishnamohan M, et al. Urinary arsenic and porphyrin profile in C57BL/6J mice chronically exposed to monomethylarsonous acid (MMAIII) for two years. Toxicol Appl Pharmacol. 2007 Oct 1;224(1):89-97. Chemical & Physical Properties Molecular Formula C36H38N4O8 PSA 205.50000 LogP 4.69760 Index of Refraction 1.638 InChIKey XNBNKCLBGTWWSD-UHFFFAOYSA-N Storage condition 2-8℃
Transport InfoProduct Name: Coproporphyrin III
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