CAS Number86347-14-0
SynonymsMedetomidine; Medetomidina; 4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole; Medetomidine [inn:ban]; (rac)-4-[1-(2,3-dimethylphenyl)ethyl]-3H-imidazole; Medetomidinum; 4-(1-(2,3-Dimethylphenyl)ethyl)-1H-imidazole; Medetomidina [spanish]; DoMtor
Molecular FormulaC13H16N2
Molecular Weight200.279
Density1.1±0.1 g/cm3
Boiling Point381.9±11.0 °C at 760 mmHg
Melting Point151.5 - 152.5ºC
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 86347-14-0 |
| Catalog No. | 2A-1170678 |
| Chinese Name | 美托咪定 |
| Synonyms | Medetomidine; Medetomidina; 4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole; Medetomidine [inn:ban]; (rac)-4-[1-(2,3-dimethylphenyl)ethyl]-3H-imidazole; Medetomidinum; 4-(1-(2,3-Dimethylphenyl)ethyl)-1H-imidazole; Medetomidina [spanish]; DoMtor |
| Molecular Formula | C13H16N2 |
| Molecular Weight | 200.279 |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 381.9±11.0 °C at 760 mmHg |
| Melting Point | 151.5 - 152.5ºC |
| Storage Condition | -20°C |
| Application | Medetomidine (Domtor) is an α2-adrenergic receptor agonist, with Ki of α2 and α1-adrenoceptors being 1.08 nM and 1750 nM respectively. |
| HTC | 2933290090 |
| PubChem ID | 7784775 |
| SMILES | Cc1cccc(C(C)c2cnc[nH]2)c1C |
| InChI | InChI=1S/C13H16N2.ClH/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13;/h4-8,11H,1-3H3,(H,14,15);1H |
| InChI Key | CUHVIMMYOGQXCV-UHFFFAOYSA-N |
| Use of | Medetomidine(Domtor) is a potent, highly selective α2-adrenoceptor agonist (Ki values are 1.08 and 1750 nM for α2- and α1-adrenoceptors respectively). IC50 value:Target: α2-adrenoceptorMedetomidine displays greater selectivity over α1-adrenoceptors than clonidine and UK 14,304 (1620-, 220- and 300-fold respectively). Medetomidine inhibits twitch response in electrically stimulated mouse vas deferens (pD2 = 9.0). Active in vivo; displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and analgesic effects. Properties Name medetomidine Synonym More Synonyms Medetomidine Biological Activity Description Medetomidine(Domtor) is a potent, highly selective α2-adrenoceptor agonist (Ki values are 1.08 and 1750 nM for α2- and α1-adrenoceptors respectively). IC50 value:Target: α2-adrenoceptorMedetomidine displays greater selectivity over α1-adrenoceptors than clonidine and UK 14,304 (1620-, 220- and 300-fold respectively). Medetomidine inhibits twitch response in electrically stimulated mouse vas deferens (pD2 = 9.0). Active in vivo; displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and analgesic effects. Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Natural Products >> Alkaloid Research Areas >> Neurological Disease References [3]. Kallio A, Koulu M, Scheinin H, Viikari J, Scheinin M. Acute effects of medetomidine, a selective alpha 2-adrenoceptor agonist, on anterior pituitary hormone and cortisol secretion in man. Acta Endocrinol (Copenh). 1988 Sep;119(1):11-5. [4]. Virtanen R, Savola JM, Saano V, Nyman L. Characterization of the selectivity, specificity and potency of medetomidine as an alpha 2-adrenoceptor agonist. Eur J Pharmacol. 1988 May 20;150(1-2):9-14. [5]. Stenberg D, Salvén P, Miettinen MV. Sedative action of the alpha 2-agonist medetomidine in cats. J Vet Pharmacol Ther. 1987 Dec;10(4):319-23. Chemical & Physical Properties Molecular Formula C13H16N2 Exact Mass 200.131348 PSA 28.68000 Index of Refraction 1.570 InChIKey CUHVIMMYOGQXCV-UHFFFAOYSA-N Safety Information HS Code 2933290090 Synthetic Route 1-benzyl-4-[1-(... 1311376-20-1 Medetomidine 86347-14-0 1416172-11-6 Medetomidine 86347-14-0 Medetomidine HC... 86347-15-1 Medetomidine 86347-14-0 Precursor & DownStream Precursor 8 CAS#:86347-15-1 Medetomidine HCl CAS#:60907-90-6 Benzenemethanol... CAS#:18156-74-6 N-(Trimethylsil... CAS#:576-23-8 2,3-Dimethylbro... DownStream 1 CAS#:86347-15-1 Medetomidine HCl |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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