CAS Number5053-08-7
SynonymsFenspiride (Hydrochloride); Fenspiride HCl; NDR-5998A; Depiride; Fluiden; Pneumorel; Tegencia hydrochloride; Viarespan hydrochloride; Espiran; 8-(2-Phenylethyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one hydrochloride; fenspiride hydrochloride
Molecular FormulaC15H21ClN2O2
Molecular Weight296.79200
Density1.19g/cm3
Boiling Point474.3ºC at 760mmHg
Melting Point235-238ºC (dec.)
Appearancepowder | white
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 5053-08-7 |
| Catalog No. | 2A-1170676 |
| Chinese Name | 盐酸芬司匹利 |
| Synonyms | Fenspiride (Hydrochloride); Fenspiride HCl; NDR-5998A; Depiride; Fluiden; Pneumorel; Tegencia hydrochloride; Viarespan hydrochloride; Espiran; 8-(2-Phenylethyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one hydrochloride; fenspiride hydrochloride |
| Molecular Formula | C15H21ClN2O2 |
| Molecular Weight | 296.79200 |
| Density | 1.19g/cm3 |
| Boiling Point | 474.3ºC at 760mmHg |
| Melting Point | 235-238ºC (dec.) |
| Appearance | powder | white |
| Water Solubility | Water solubility: soluble |
| Storage Condition | Refrigerator |
| Application | Fenspiride hydrochloride is an adrenergic and H1 receptor antagonist. |
| PubChem ID | 8149701 |
| SMILES | Cl.O=C1NCC2(CCN(CCc3ccccc3)CC2)O1 |
| InChI | InChI=1S/C15H20N2O2.ClH/c18-14-16-12-15(19-14)7-10-17(11-8-15)9-6-13-4-2-1-3-5-13;/h1-5H,6-12H2,(H,16,18);1H |
| InChI Key | FIKFLLIUPUVONI-UHFFFAOYSA-N |
| Hazard Symbols | transportation |
| Bioactivity | Fenspiride Hcl is an α adrenergic and H1 histamine receptor antagonist.IC50 value:Target: Adrenergic receptor; H1 receptorFenspiride hydrochloride is a bronchodilator with anti-inflammatory properties. Fenspiride hydrochloride inhibits mucus secretion and reduces the release of tachykinins at a prejunctional level. Fenspiride hydrochloride also may be an antagonist at α adrenergic and H1 histamine receptors. Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Natural Products >> Alkaloid Research Areas >> Inflammation/Immunology References [1]. Lebedenko AA, Mal'tsev SV. .[The efficacy of application of fenspiride (erespal) for the treatment of exacerbation of bronchial asthma in children.] Vestn Otorinolaringol. 2011;(4):66-67. [2]. Khawaja AM, Liu YC, Rogers DF. et al.Effect of fenspiride, a non-steroidal antiinflammatory agent, on neurogenic mucus secretion in ferret trachea in vitro. Pulm Pharmacol Ther. 1999;12(6):363-8. [3]. Zielnik-Jurkiewicz B, Jurkiewicz D. et al. Usefulness of fenspiride in the treatment of acute otitis media in children. Pol Merkur Lekarski. 2005 Jun;18(108):624-8. [4]. Bee D, Laude EA, Emery CJ, Howard P. Effect of fenspiride on pulmonary function in the rat and guinea pig. Clin Sci (Lond). 1995 Mar;88(3):325-30. [5]. Fenspiride Chemical & Physical Properties Density 1.19g/cm3 Boiling Point 474.3ºC at 760mmHg Melting Point 235-238ºC (dec.) Molecular Formula C15H21ClN2O2 Molecular Weight 296.79200 Flash Point 240.6ºC Exact Mass 296.12900 PSA 41.57000 LogP 2.87220 Appearance of Characters powder | white InChIKey FIKFLLIUPUVONI-UHFFFAOYSA-N SMILES Cl.O=C1NCC2(CCN(CCc3ccccc3)CC2)O1 Storage condition Refrigerator |
| Use of | Fenspiride Hcl is an α adrenergic and H1 histamine receptor antagonist.IC50 value:Target: Adrenergic receptor; H1 receptorFenspiride hydrochloride is a bronchodilator with anti-inflammatory properties. Fenspiride hydrochloride inhibits mucus secretion and reduces the release of tachykinins at a prejunctional level. Fenspiride hydrochloride also may be an antagonist at α adrenergic and H1 histamine receptors. Properties Name 8-(2-phenylethyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one,hydrochloride Synonym More Synonyms fenspiride hydrochloride Biological Activity Description Fenspiride Hcl is an α adrenergic and H1 histamine receptor antagonist.IC50 value:Target: Adrenergic receptor; H1 receptorFenspiride hydrochloride is a bronchodilator with anti-inflammatory properties. Fenspiride hydrochloride inhibits mucus secretion and reduces the release of tachykinins at a prejunctional level. Fenspiride hydrochloride also may be an antagonist at α adrenergic and H1 histamine receptors. Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Natural Products >> Alkaloid Research Areas >> Inflammation/Immunology References [1]. Lebedenko AA, Mal'tsev SV. .[The efficacy of application of fenspiride (erespal) for the treatment of exacerbation of bronchial asthma in children.] Vestn Otorinolaringol. 2011;(4):66-67. [2]. Khawaja AM, Liu YC, Rogers DF. et al.Effect of fenspiride, a non-steroidal antiinflammatory agent, on neurogenic mucus secretion in ferret trachea in vitro. Pulm Pharmacol Ther. 1999;12(6):363-8. [3]. Zielnik-Jurkiewicz B, Jurkiewicz D. et al. Usefulness of fenspiride in the treatment of acute otitis media in children. Pol Merkur Lekarski. 2005 Jun;18(108):624-8. [4]. Bee D, Laude EA, Emery CJ, Howard P. Effect of fenspiride on pulmonary function in the rat and guinea pig. Clin Sci (Lond). 1995 Mar;88(3):325-30. [5]. Fenspiride Chemical & Physical Properties Exact Mass 296.12900 PSA 41.57000 LogP 2.87220 Appearance of Characters powder | white InChIKey FIKFLLIUPUVONI-UHFFFAOYSA-N Storage condition Refrigerator |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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