CAS Number130465-39-3
Synonymscis-1-(Aminomethyl)-3-phenylisochroman-5,6-diol hydrochloride; (1R,3S)-1-(aminomethyl)-3-phenyl-3,4-dihydro-1H-isochromene-5,6-diol,hydrochloride
Molecular FormulaC16H18ClNO3
Molecular Weight307.77200
Purity98.00%
Melting Point250ºC
Appearanceoff-white solid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 130465-39-3 |
| Catalog No. | 2A-1170635 |
| Chinese Name | 1-(氨基甲基)-3,4-二氢-3-苯基-1H-2-苯并吡喃-5,6-二醇盐酸盐 |
| Synonyms | cis-1-(Aminomethyl)-3-phenylisochroman-5,6-diol hydrochloride; (1R,3S)-1-(aminomethyl)-3-phenyl-3,4-dihydro-1H-isochromene-5,6-diol,hydrochloride |
| Molecular Formula | C16H18ClNO3 |
| Molecular Weight | 307.77200 |
| Purity | 98.00 |
| Melting Point | 250ºC |
| Appearance | off-white solid |
| Storage Condition | -20°C |
| Application | A68930 hydrochloride, as a dopamine D1 receptor agonist, can be used in the study of bronchiectasis [1]. |
| HTC | 2932999099 |
| PubChem ID | 14874115 |
| SMILES | Cl.NCC1OC(c2ccccc2)Cc2c1ccc(O)c2O |
| InChI | InChI=1S/C16H17NO3.ClH/c17-9-15-11-6-7-13(18)16(19)12(11)8-14(20-15)10-4-2-1-3-5-10;/h1-7,14-15,18-19H,8-9,17H2;1H/t14-,15-;/m0./s1 |
| InChI Key | PQPGUUQPTSMLKU-YYLIZZNMSA-N |
| Hazard Symbols | transportation |
| Bioactivity | A68930 hydrochloride, as a dopamine D1 receptor agonist, can be used for the research of bronchiectasis[1]. Related Catalog Research Areas >> Others Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Target D1 Receptor In Vitro A68930 hydrochloride (1 μM; 5-60 minutes; 16HBE14o- or NCI-H292 cells) significantly increases phosphorylation of cAMP response element binding (CREB) protein[1]. A68930 hydrochloride (1 μM; 48 hours; NCI-H292 cells) induces MUC5AC mRNA expression and increases the mRNA data of MUC5AC and MUC5AC protein expression[1]. A68930 hydrochloride (1 μM; 20 minutes; NCI-H292 cells) significantly increases intracellular cAMP levels[1]. Western Blot Analysis[1] Cell Line: 16HBE14o- or NCI-H292 cells Concentration: 1 μM Incubation Time: 5~60 minutes Result: Significantly increased phosphorylation of CREB. RT-PCR[1] Cell Line: NCI-H292 cells Concentration: 1 μM Incubation Time: 48 hours Result: Induced MUC5AC mRNA expression. Immunofluorescence[1] Cell Line: NCI-H292 cells Concentration: 1 μM Incubation Time: 48 hours Result: The mRNA data of MUC5AC, MUC5AC protein expression were increased. References [1]. Matsuyama N, et al. The dopamine D1 receptor is expressed and induces CREB phosphorylation and MUC5AC expression in human airway epithelium. Respir Res. 2018;19(1):53. Published 2018 Apr 2. Chemical & Physical Properties Melting Point 250ºC Molecular Formula C16H18ClNO3 Molecular Weight 307.77200 Exact Mass 307.09800 PSA 75.71000 LogP 3.91390 InChIKey PQPGUUQPTSMLKU-YYLIZZNMSA-N SMILES Cl.NCC1OC(c2ccccc2)Cc2c1ccc(O)c2O Storage condition -20°C |
| Use of | A68930 hydrochloride, as a dopamine D1 receptor agonist, can be used for the research of bronchiectasis[1]. Properties Name A-68930 hydrochloride Synonym More Synonyms A-68930 hydrochloride Biological Activity Description A68930 hydrochloride, as a dopamine D1 receptor agonist, can be used for the research of bronchiectasis[1]. Related Catalog Research Areas >> Others Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor D1 Receptor References [1]. Matsuyama N, et al. The dopamine D1 receptor is expressed and induces CREB phosphorylation and MUC5AC expression in human airway epithelium. Respir Res. 2018;19(1):53. Published 2018 Apr 2. Chemical & Physical Properties Exact Mass 307.09800 PSA 75.71000 LogP 3.91390 InChIKey PQPGUUQPTSMLKU-YYLIZZNMSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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