CAS Number86-34-0
Synonyms1-methyl-3-phenyl-pyrrolidine-2,5-dione; 1-methyl-3-phenylsuccinimide; Milontin; Lifen; Mirotin; Lifene; Mirontin; 1-Methyl-3-phenyl-pyrrolidin-2,5-dion; Milonton; Epimal; Epimid; N-methylphenylsuccinimide; PM 334
Molecular FormulaC11H11NO2
Molecular Weight189.21100
Purity98.00%
Density1.1596 (rough estimate)
Boiling Point324.47°C (rough estimate)
Melting Point71-73°
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 86-34-0 |
| Catalog No. | 2A-1170631 |
| Chinese Name | 苯琥胺 |
| Synonyms | 1-methyl-3-phenyl-pyrrolidine-2,5-dione; 1-methyl-3-phenylsuccinimide; Milontin; Lifen; Mirotin; Lifene; Mirontin; 1-Methyl-3-phenyl-pyrrolidin-2,5-dion; Milonton; Epimal; Epimid; N-methylphenylsuccinimide; PM 334 |
| Molecular Formula | C11H11NO2 |
| Molecular Weight | 189.21100 |
| Purity | 98.00 |
| Density | 1.1596 (rough estimate) |
| Boiling Point | 324.47°C (rough estimate) |
| Melting Point | 71-73° |
| Storage Condition | 2-8°C |
| Application | Phensuximide is a succinimide antiepileptic and anticonvulsant agent. Phensuximide inhibits the accumulation of cyclic AMP and cyclic GMP in depolarized brain tissue. In animal models, Phensuximide ca |
| HTC | 2925190090 |
| PubChem ID | 9641 |
| SMILES | CN1C(=O)CC(c2ccccc2)C1=O |
| InChI | InChI=1S/C11H11NO2/c1-12-10(13)7-9(11(12)14)8-5-3-2-4-6-8/h2-6,9H,7H2,1H3 |
| InChI Key | WLWFNJKHKGIJNW-UHFFFAOYSA-N |
| Use of | Phensuximide is an orally active succinimide antiepileptic and anticonvulsant agent. Phensuximide inhibits cyclic AMP and cyclic GMP accumulation in depolarized brain tissue. Phensuximide can be used for the study of seizure and petit mal[1][3]. Properties Name phensuximide Synonym More Synonyms Phensuximide Biological Activity Description Phensuximide is an orally active succinimide antiepileptic and anticonvulsant agent. Phensuximide inhibits cyclic AMP and cyclic GMP accumulation in depolarized brain tissue. Phensuximide can be used for the study of seizure and petit mal[1][3]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease Research Areas >> Neurological Disease IC50: cyclic AMP and cyclic GMP accumulation[2] References [1]. G O Rankin, et al. Urinary Tract Effects of Phensuximide in the Sprague-Dawley and Fischer 344 Rat. J Appl Toxicol. . 1986 Oct;6(5):349-56. [2]. J A Ferrendelli, et al. Inhibitory Effects of Anticonvulsant Drugs on Cyclic Nucleotide Accumulation in Brain. Ann Neurol. 1979 Jun;5(6):533-8. [3]. J G MILLICHAP, et al. Milontin: A New Drug in the Treatment of Petit Mal.Lancet. 1952 Nov 8;2(6741):907-10. [4]. S D Hall,et al. Characterization and inhibition of mephenytoin 4-hydroxylase activity in human liver microsomes. The JOURNAL OP PHARMAcOLOGY AND EXPERIMENTAL THERAPEUTICS Chemical & Physical Properties Molecular Formula C11H11NO2 Exact Mass 189.07900 PSA 37.38000 LogP 1.09680 Index of Refraction 1.5012 (estimate) InChIKey WLWFNJKHKGIJNW-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Succinimide, N-methyl-2-phenyl- CAS REGISTRY NUMBER : BEILSTEIN REFERENCE NO. : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C11-H11-N-O2 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : T5VNVTJ B1 DR HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Kidney, Ureter, Bladder - proteinuria Kidney, Ureter, Bladder - hematuria Kidney, Ureter, Bladder - inflammation, necrosis, or scarring of bladder TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SEX/DURATION : female 8-10 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - other developmental abnormalities TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Unreported SEX/DURATION : female 8-10 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system MUTATION DATA TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Human Leukocyte DOSE/DURATION : REFERENCE : AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- Volume(issue)/page/year: 116,867,1973 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4457 No. of Facilities: 46 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 279 (estimated) No. of Female Employees: 46 (estimated) Safety Information RIDADR NONH for all modes of transport HS Code 2925190090 Synthetic Route 2-(Dimethylphen... 853955-69-8 N-Methylmaleimi... Phensuximide Literature: Nakao, Yoshiaki; Chen, Jinshui; Imanaka, Hidekazu; Hiyama, Tamejiro; Ichikawa, Yoshitaka; Duan, Wei-Liang; Shintani, Ryo; Hayashi, Tamio Journal of the American Chemical Society, 2007 , vol. 129, # 29 p. 9137 - 9143 Phenylsuccinic ... methylamine Phensuximide Literature: Collection of Czechoslovak Chemical Communications, , vol. 24, p. 804,807 Journal of the American Chemical Society, , vol. 73, p. 4895,4897 1-methyl-3-(met... 398130-26-2 Phensuximide Literature: Shigemitsu, Yasuhiro; Tominaga, Yoshinori Heterocycles, 2001 , vol. 55, # 12 p. 2257 - 2260 Precursor & DownStream Precursor 8 CAS#:853955-69-8 2-(Dimethylphen... CAS#:930-88-1 N-Methylmaleimide CAS#:635-51-8 Phenylsuccinic acid CAS#:74-89-5 methylamine DownStream 1 CAS#:54433-49-7 1H-Pyrrole-2,5-... |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
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