
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 37000-20-7 |
| Catalog No. | 2A-1170462 |
| Chinese Name | 净特罗 |
| Synonyms | ZINTEROL; MJ-9184-1; Zinterolum; Allopregnanolone |
| Molecular Formula | C19H26N2O4S |
| Molecular Weight | 378.48600 |
| Purity | 98.00 |
| Density | 1.282g/cm3 |
| Boiling Point | 574.3ºC at 760mmHg |
| Storage Condition | -20°C |
| Application | Zinterol (MJ 9184) is a potent and selective β2-adrenoceptor (β2-adrenoceptor) agonist. Zinterol enhances ICa with an EC50 of 2.2 nM. |
| HTC | 2935009090 |
| PubChem ID | 5757686 |
| SMILES | CC(C)(Cc1ccccc1)NCC(O)c1ccc(O)c(NS(C)(=O)=O)c1 |
| InChI | InChI=1S/C19H26N2O4S.ClH/c1-19(2,12-14-7-5-4-6-8-14)20-13-18(23)15-9-10-17(22)16(11-15)21-26(3,24)25;/h4-11,18,20-23H,12-13H2,1-3H3;1H |
| InChI Key | XJBCFFLVLOPYBV-UHFFFAOYSA-N |
| Use of | Zinterol (MJ 9184) is a potent and selective β2-adrenoceptor agonist[1]. Zinterol increases ICa in a concentration-dependent manner with an EC50 of 2.2 nM[2]. Properties Name N-[2-hydroxy-5-[1-hydroxy-2-[(2-methyl-1-phenylpropan-2-yl)amino]ethyl]phenyl]methanesulfonamide Synonym More Synonyms Zinterol Biological Activity Description Zinterol (MJ 9184) is a potent and selective β2-adrenoceptor agonist[1]. Zinterol increases ICa in a concentration-dependent manner with an EC50 of 2.2 nM[2]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor β2-adrenoceptor[1] References [1]. Gwee MC, et al. Pharmacological actions of a new -adrenoceptor agonist, MJ-9184-1, in anaesthetized cats. Br J Pharmacol. 1972 Nov;46(3):375-85. [2]. Skeberdis VA, et al. Beta-2 adrenergic activation of L-type Ca2+ current in cardiac myocytes. J Pharmacol Exp Ther. 1997 Nov;283(2):452-61. [3]. Desantiago J, et al. Arrhythmogenic effects of beta2-adrenergic stimulation in the failing heart are attributable to enhanced sarcoplasmic reticulum Ca load. Circ Res. 2008 Jun 6;102(11):1389-97. Chemical & Physical Properties Molecular Formula C19H26N2O4S Exact Mass 378.16100 PSA 107.04000 LogP 3.95270 Index of Refraction 1.615 InChIKey XJBCFFLVLOPYBV-UHFFFAOYSA-N Safety Information Hazard Codes Xi HS Code 2935009090 |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 35.0% |
| Transport Info | Product name: Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
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