CAS Number300-84-5
Synonyms2-Aminoethanesulfinic acid; 2-Amino-aethansulfinsaeure; MFCD00038197; aminoethylsulfinic acid; 2-amino-Ethanesulfinic acid; 2-aminoethanesulfinate; Cystaminesulfinic acid; 2-Aminoethylsulfinate; 2-Aminoethylsulfinic acid; Ethanesulfinic acid,2-amino; Hypotaurine; Cystaminesulfinate
Molecular FormulaC2H7NO2S
Molecular Weight109.147
Purity98.00%
Density1.5±0.1 g/cm3
Boiling Point354.9±44.0 °C at 760 mmHg
AppearanceWhite
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 300-84-5 |
| Catalog No. | 2A-1170456 |
| Chinese Name | 2-氨基乙烷亚磺酸 |
| Synonyms | 2-Aminoethanesulfinic acid; 2-Amino-aethansulfinsaeure; MFCD00038197; aminoethylsulfinic acid; 2-amino-Ethanesulfinic acid; 2-aminoethanesulfinate; Cystaminesulfinic acid; 2-Aminoethylsulfinate; 2-Aminoethylsulfinic acid; Ethanesulfinic acid,2-amino; Hypotaurine; Cystaminesulfinate |
| Molecular Formula | C2H7NO2S |
| Molecular Weight | 109.147 |
| Purity | 98.00 |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 354.9±44.0 °C at 760 mmHg |
| Appearance | White |
| Water Solubility | H2O: 100 mg/mL |
| Storage Condition | Store sealed in a dry and dark place. |
| Application | Hypotaurine (2-aminoethanesulfinic acid) is a taurine biosynthetic intermediate of cysteine in astrocytes and an endogenous inhibitory amino acid of glycine receptor. |
| HTC | 2930909090 |
| PubChem ID | 3802 |
| SMILES | NCCS(=O)O |
| InChI | InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5)/p-1 |
| InChI Key | VVIUBCNYACGLLV-UHFFFAOYSA-N |
| Hazard Symbols | transportation |
| MSDS | msds/170618_2_300_84_5.pdf |
| Bioactivity | Hypotaurine (2-aminoethanesulfinic acid), an intermediate in taurine biosynthesis from cysteine in astrocytes, is an endogenous inhibitory amino acid of the glycine receptor. Related Catalog Research Areas >> Neurological Disease Natural Products >> Others Target Human Endogenous Metabolite In Vitro Hypotaurine and taurine are found to reside within the cytosolic compartment of the cell. The ratio of taurine to hypotaurine is approx 50:1. The cytosolic concentration of taurine is approx. 50 mM. The concentration of hypotaurine decreases by 80% when resting neutrophils are converted into actively respiring cells by exposure to opsonized zymosan[1]. Hypotaurine activates hypoxia signaling through the competitive inhibition of prolyl hydroxylase domain-2. This leads to the activation of hypoxia signaling as well as to the enhancement of glioma cell proliferation and invasion[2]. In Vivo Hypotaurine has antinociceptive effects on thermal, mechanical, and chemical nociception in the spinal cord. In CCI rats, hypotaurine alleviates mechanical allodynia and thermal hyperalgesia. Intrathecal hypotaurine suppresses acute, inflammatory, and neuropathic pain. Hypotaurine may regulate nociceptive transmission physiologically by activating glycinergic neurons in the spinal cord[3]. Animal Admin Rats: A radiant heat source is focused on the middle part of the rat's tail. The time interval from the onset of the stimulus until the tail flick response is measured using a tail flick unit. The intensity of the radiant heat is adjusted to give a tail flick latency of 4-5 s before the administration of hypotaurine or saline. In the absence of a response, the stimulus is terminated after 15 s (cutoff) to prevent tissue damage. The effects of hypotaurine (100, 200, 400, and 600 μg) on thermal nociception are assessed repeatedly for 120 min post-injection[3]. References [1]. Green TR, et al. Antioxidant role and subcellular location of hypotaurine and taurine in human neutrophils. Biochim Biophys Acta. 1991 Jan 23;1073(1):91-7. https://www.ncbi.nlm.nih.gov/pubmed/1846756 [2]. Gao P, et al. Hypotaurine evokes a malignant phenotype in glioma through aberrant hypoxic signaling. Oncotarget. 2016 Mar 22;7(12):15200-14. [3]. Hara K, et al. Antinociceptive effect of intrathecal administration of hypotaurine in rat models of inflammatory and neuropathic pain. Amino Acids. 2012 Jul;43(1):397-404. Hara K, et al. Antinociceptive effect of intrathecal administration of hypotaurine in rat models of inflammatory and neuropathic pain. Amino Acids. 2012 Jul;43(1):397-404. Chemical & Physical Properties Density 1.5±0.1 g/cm3 Boiling Point 354.9±44.0 °C at 760 mmHg Molecular Formula C2H7NO2S Molecular Weight 109.147 Flash Point 168.5±28.4 °C Exact Mass 109.019745 PSA 82.53000 LogP -2.03 Vapour Pressure 0.0±1.7 mmHg at 25°C Index of Refraction 1.616 InChIKey VVIUBCNYACGLLV-UHFFFAOYSA-N SMILES NCCS(=O)O Storage condition Desiccate at RT Water Solubility H2O: 100 mg/mL |
| Use of | Hypotaurine (2-aminoethanesulfinic acid), an intermediate in taurine biosynthesis from cysteine in astrocytes, is an endogenous inhibitory amino acid of the glycine receptor. Properties Articles65 Name hypotaurine Synonym More Synonyms HYPOTAURINE Biological Activity Description Hypotaurine (2-aminoethanesulfinic acid), an intermediate in taurine biosynthesis from cysteine in astrocytes, is an endogenous inhibitory amino acid of the glycine receptor. Related Catalog Research Areas >> Neurological Disease Natural Products >> Others Human Endogenous Metabolite In Vivo Hypotaurine has antinociceptive effects on thermal, mechanical, and chemical nociception in the spinal cord. In CCI rats, hypotaurine alleviates mechanical allodynia and thermal hyperalgesia. Intrathecal hypotaurine suppresses acute, inflammatory, and neuropathic pain. Hypotaurine may regulate nociceptive transmission physiologically by activating glycinergic neurons in the spinal cord[3]. References [1]. Green TR, et al. Antioxidant role and subcellular location of hypotaurine and taurine in human neutrophils. Biochim Biophys Acta. 1991 Jan 23;1073(1):91-7. https://www.ncbi.nlm.nih.gov/pubmed/1846756 [2]. Gao P, et al. Hypotaurine evokes a malignant phenotype in glioma through aberrant hypoxic signaling. Oncotarget. 2016 Mar 22;7(12):15200-14. [3]. Hara K, et al. Antinociceptive effect of intrathecal administration of hypotaurine in rat models of inflammatory and neuropathic pain. Amino Acids. 2012 Jul;43(1):397-404. Hara K, et al. Antinociceptive effect of intrathecal administration of hypotaurine in rat models of inflammatory and neuropathic pain. Amino Acids. 2012 Jul;43(1):397-404. Chemical & Physical Properties Molecular Formula C2H7NO2S Exact Mass 109.019745 PSA 82.53000 LogP -2.03 Index of Refraction 1.616 InChIKey VVIUBCNYACGLLV-UHFFFAOYSA-N SMILES NCCS(=O)O Storage condition Desiccate at RT |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 United Nations number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special precautions No data available |
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