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SU 6656 structure, CAS 330161-87-0

SU 6656

CAS Number330161-87-0

Synonyms(3Z)-N,N-Dimethyl-2-oxo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylene)-5-indolinesulfonamide; (3Z)-N,N-Dimethyl-2-oxo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylene)indoline-5-sulfonamide; SU6656

Molecular FormulaC19H21N3O3S

Molecular Weight371.453

Purity

Density1.4±0.1 g/cm3

Boiling Point

Melting Point

Flash Point

Appearancepowder

EINECS

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Cat. No.: 2A-1170324 Purity:
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Quality Control of [ 330161-87-0 ] SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number330161-87-0
Catalog No.2A-1170324
Chinese Name2,3-二氢-N,N-二甲基-2-氧代-3-[(4,5,6,7-四氢-1H-吲哚-2-基)亚甲基] -1H-吲哚-5-磺酰胺
Synonyms(3Z)-N,N-Dimethyl-2-oxo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylene)-5-indolinesulfonamide; (3Z)-N,N-Dimethyl-2-oxo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylene)indoline-5-sulfonamide; SU6656
Molecular FormulaC19H21N3O3S
Molecular Weight371.453
Density1.4±0.1 g/cm3
Appearancepowder
Storage Condition-20℃
ApplicationSU 6656 is a Src family kinase inhibitor. The IC50 for inhibiting Src, Yes, Lyn, and Fyn is 280, 20, 130, and 170 nM respectively.
PubChem ID5620781
SMILESCN(C)S(=O)(=O)c1ccc2c(c1)C(=Cc1cc3c([nH]1)CCCC3)C(=O)N2
InChIInChI=1S/C19H21N3O3S/c1-22(2)26(24,25)14-7-8-18-15(11-14)16(19(23)21-18)10-13-9-12-5-3-4-6-17(12)20-13/h7-11,20H,3-6H2,1-2H3,(H,21,23)/b16-10+
InChI KeyLOGJQOUIVKBFGH-YBEGLDIGSA-N
Hazard Symbolstransportation
MSDSmsds/170475_2_330161_87_0.pdf
BioactivitySU 6656 is a Src family kinases inhibitor with IC50s of 280, 20, 130, 170 nM for Src, Yes, Lyn, and Fyn, respectively. Related Catalog Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Src Research Areas >> Cancer References [1]. Blake RA, et al. SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling. Mol Cell Biol. 2000 Dec;20(23):9018-27. [2]. Veracini L, et al. Elevated Src family kinase activity stabilizes E-cadherin-based junctions and collective movement of head and neck squamous cell carcinomas. Oncotarget. 2014 Dec 26. [3]. Wu ML, et al. Divergent signaling pathways cooperatively regulate TGFβ induction of cysteine-rich protein 2 in vascular smooth muscle cells. Cell Commun Signal. 2014 Mar 28;12:22. [4]. Ondrusová L, et al. Inhibition of mTORC1 by SU6656, the selective Src kinase inhibitor, is not accompanied by activation of Akt/PKB signalling in melanoma cells. Folia Biol (Praha). 2013;59(4):162-7. [5]. Kumar A, et al. Pharmacological investigations on possible role of Src kinases in neuroprotective mechanism of ischemic postconditioning in mice. Int J Neurosci. 2014 Oct;124(10):777-86. [6]. Liu XF, et al. Antitumor effects of immunotoxins are enhanced by lowering HCK or treatment with SRC kinase inhibitors. Mol Cancer Ther. 2014 Jan;13(1):82-9. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Molecular Formula C19H21N3O3S Molecular Weight 371.453 Exact Mass 371.130371 PSA 90.65000 LogP 3.46 Index of Refraction 1.657 InChIKey LOGJQOUIVKBFGH-YBEGLDIGSA-N SMILES CN(C)S(=O)(=O)c1ccc2c(c1)C(=Cc1cc3c([nH]1)CCCC3)C(=O)N2 Storage condition -20℃
Use ofSU 6656 is a Src family kinases inhibitor with IC50s of 280, 20, 130, 170 nM for Src, Yes, Lyn, and Fyn, respectively. Properties Name su 6656 Synonym More Synonyms SU6656 Biological Activity Description SU 6656 is a Src family kinases inhibitor with IC50s of 280, 20, 130, 170 nM for Src, Yes, Lyn, and Fyn, respectively. Related Catalog Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Src Research Areas >> Cancer References [1]. Blake RA, et al. SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling. Mol Cell Biol. 2000 Dec;20(23):9018-27. [2]. Veracini L, et al. Elevated Src family kinase activity stabilizes E-cadherin-based junctions and collective movement of head and neck squamous cell carcinomas. Oncotarget. 2014 Dec 26. [3]. Wu ML, et al. Divergent signaling pathways cooperatively regulate TGFβ induction of cysteine-rich protein 2 in vascular smooth muscle cells. Cell Commun Signal. 2014 Mar 28;12:22. [4]. Ondrusová L, et al. Inhibition of mTORC1 by SU6656, the selective Src kinase inhibitor, is not accompanied by activation of Akt/PKB signalling in melanoma cells. Folia Biol (Praha). 2013;59(4):162-7. [5]. Kumar A, et al. Pharmacological investigations on possible role of Src kinases in neuroprotective mechanism of ischemic postconditioning in mice. Int J Neurosci. 2014 Oct;124(10):777-86. [6]. Liu XF, et al. Antitumor effects of immunotoxins are enhanced by lowering HCK or treatment with SRC kinase inhibitors. Mol Cancer Ther. 2014 Jan;13(1):82-9. Chemical & Physical Properties Molecular Formula C19H21N3O3S Exact Mass 371.130371 PSA 90.65000 Index of Refraction 1.657 InChIKey LOGJQOUIVKBFGH-YBEGLDIGSA-N Storage condition -20℃
Transport InfoProduct name: Purity: 97.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available
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