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Home > Products > Pharmaceutical R&D Materials > Heterocyclic Building Blocks > 2-(2-Chlorophenyl)-4-(3-(diMethylaMino)phenyl)-5-Methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione
2-(2-Chlorophenyl)-4-(3-(diMethylaMino)phenyl)-5-Methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione structure, CAS 1218942-37-0

2-(2-Chlorophenyl)-4-(3-(diMethylaMino)phenyl)-5-Methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione

CAS Number1218942-37-0

Synonyms2-(2-Chlorophenyl)-4-(3-(dimethylamino)phenyl)-5-methyl-1H-pyrazolo(4,3-c)pyridine-3,6(2H,5H)-dione; 2-(2-Chlorophenyl)-4-[3-(dimethylamino)phenyl]-5-methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione; GKT137831

Molecular FormulaC21H19ClN4O2

Molecular Weight394.854

Purity

Density1.4±0.1 g/cm3

Boiling Point560.5±60.0 °C at 760 mmHg

Melting Point

Flash Point

Appearancepowder

EINECS

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Symbol

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Cat. No.: 2A-1170279 Purity:
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Quality Control of [ 1218942-37-0 ] SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number1218942-37-0
Catalog No.2A-1170279
Chinese NameGKT137831
Synonyms2-(2-Chlorophenyl)-4-(3-(dimethylamino)phenyl)-5-methyl-1H-pyrazolo(4,3-c)pyridine-3,6(2H,5H)-dione; 2-(2-Chlorophenyl)-4-[3-(dimethylamino)phenyl]-5-methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione; GKT137831
Molecular FormulaC21H19ClN4O2
Molecular Weight394.854
Density1.4±0.1 g/cm3
Boiling Point560.5±60.0 °C at 760 mmHg
Appearancepowder
Storage Condition-20℃
ApplicationGKT137831 is a selective NADPH oxidase (NOX1/4) inhibitor with Ki of 140 and 110nM respectively.
HTC2933990090
PubChem ID138845995
SMILESCN(C)c1cccc(-c2c3c(=O)n(-c4ccccc4Cl)[nH]c3cc(=O)n2C)c1
InChIInChI=1S/C21H19ClN4O2/c1-24(2)14-8-6-7-13(11-14)20-19-16(12-18(27)25(20)3)23-26(21(19)28)17-10-5-4-9-15(17)22/h4-12,23H,1-3H3
InChI KeyRGYQPQARIQKJKH-UHFFFAOYSA-N
Use ofProperties Name 2-(2-chlorophenyl)-4-[3-(dimethylamino)phenyl]-5-methyl-1H-pyrazolo[4,3-c]pyridine-3,6-dione Synonym More Synonyms Setanaxib (GKT137831) Biological Activity Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Cardiovascular Disease Cell Assay Monolayers of HPAECs and HPASMCs are propagated in culture and placed in normoxic (21% O2, 5% CO2) or hypoxic (1% O2, 5% CO2) conditions for 72 hours. GKT137831 (0.1-20 μM), or vehicle (1% DMSO) are added to the culture medium at the onset (prevention regimen) or during the last 24 hours (intervention regimen) of a 72-hour hypoxia exposure regimen[2]. References [1]. Aoyama T, et al. Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent. Hepatology. 2012 Dec;56(6):2316-27. [2]. Green DE, et al. The Nox4 inhibitor GKT137831 attenuates hypoxia-induced pulmonary vascular cell proliferation. Am J Respir Cell Mol Biol. 2012 Nov;47(5):718-26. Chemical & Physical Properties Exact Mass 394.119659 PSA 63.03000 Index of Refraction 1.713 InChIKey RGYQPQARIQKJKH-UHFFFAOYSA-N Storage condition -20℃ Safety Information HS Code 2933990090
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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