![6-(4-FLUOROPHENYL)-2,3-DIHYDRO-5-(4-PYRIDINYL)IMIDAZO[2,1-B]THIAZOLE DIHYDROCHLORIDE structure, CAS 72873-74-6](/structures/180000/170404_2_72873_74_6.png)
CAS Number72873-74-6
Synonyms5-(4-pyridyl)-6-(4-fluorophenyl)-2,3-dihydroimidazo(2,1-b)-thiazole; MFCD00869367; 6-(4-Fluorophenyl)-5-(4-pyridinyl)-2,3-dihydroimidazo[2,1-b][1,3]thiazole; 6-(4-Fluorophenyl)-5-(pyridin-4-yl)-2,3-dihydroimidazo[2,1-b][1,3]thiazole; SKF-86002
Molecular FormulaC16H12FN3S
Molecular Weight297.350
Density1.4±0.1 g/cm3
Boiling Point476.1±55.0 °C at 760 mmHg
Melting Point189-190ºC(lit.)
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 72873-74-6 |
| Catalog No. | 2A-1170259 |
| Chinese Name | 6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氢咪唑并[2,1-B]-噻唑 |
| Synonyms | 5-(4-pyridyl)-6-(4-fluorophenyl)-2,3-dihydroimidazo(2,1-b)-thiazole; MFCD00869367; 6-(4-Fluorophenyl)-5-(4-pyridinyl)-2,3-dihydroimidazo[2,1-b][1,3]thiazole; 6-(4-Fluorophenyl)-5-(pyridin-4-yl)-2,3-dihydroimidazo[2,1-b][1,3]thiazole; SKF-86002 |
| Molecular Formula | C16H12FN3S |
| Molecular Weight | 297.350 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 476.1±55.0 °C at 760 mmHg |
| Melting Point | 189-190ºC(lit.) |
| Storage Condition | Store in an airtight container in a cool, dry plac |
| Application | SKF-86002 is a p38MAPK inhibitor with an IC50 value of 0.5-1uM. |
| HTC | 2934100090 |
| PubChem ID | 598789 |
| SMILES | Fc1ccc(-c2nc3n(c2-c2ccncc2)CCS3)cc1 |
| InChI | InChI=1S/C16H12FN3S/c17-13-3-1-11(2-4-13)14-15(12-5-7-18-8-6-12)20-9-10-21-16(20)19-14/h1-8H,9-10H2 |
| InChI Key | YOELZIQOLWZLQC-UHFFFAOYSA-N |
| Use of | Properties Articles24 Name 6-(4-fluorophenyl)-5-pyridin-4-yl-2,3-dihydroimidazo[2,1-b][1,3]thiazole Synonym More Synonyms SKF 86002 Biological Activity Related Catalog Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Research Areas >> Inflammation/Immunology References [1]. Griswold DE, et al. SK&F 86002: a structurally novel anti-inflammatory agent that inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid. Biochem Pharmacol. 1987 Oct 15;36(20):3463-70. [3]. Nick JA, et al. Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP. J Clin Invest. 1997 Mar 1;99(5):975-86. Chemical & Physical Properties Molecular Formula C16H12FN3S Exact Mass 297.073608 PSA 56.01000 Index of Refraction 1.713 InChIKey YOELZIQOLWZLQC-UHFFFAOYSA-N Storage condition 2-8℃ Safety Information Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves Hazard Codes Xi: Irritant; Safety Phrases 26-36 RIDADR NONH for all modes of transport HS Code 2934100090 Synthetic Route 5-(N-ethoxycarb... CAS#:106465-75-2 CAS#:72873-74-6 Literature: Lantos, Ivan; Gombatz, Kerry; McGuire, Michael; Pridgen, Lendon; Remich, James; Shilcrat, Susan Journal of Organic Chemistry, 1988 , vol. 53, # 18 p. 4223 - 4227 1-(4-fluorophen... CAS#:87532-41-0 CAS#:72873-74-6 Literature: Lantos, I.; Bender, P. E.; Razgaitis, K. A.; Sutton, B. M.; DiMartino, M. J.; et al. Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 72 - 75 CAS#:110-86-1 CAS#:72873-74-6 Literature: Lantos, Ivan; Gombatz, Kerry; McGuire, Michael; Pridgen, Lendon; Remich, James; Shilcrat, Susan Journal of Organic Chemistry, 1988 , vol. 53, # 18 p. 4223 - 4227 Precursor & DownStream Precursor 5 CAS#:106465-75-2 5-(N-ethoxycarb... CAS#:87532-41-0 1-(4-fluorophen... CAS#:110-86-1 CAS#:72882-75-8 4-(4-fluorophen... DownStream 1 CAS#:72873-77-9 6-(4-fluorophen... |
| Tax Rebate | 9.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0% |
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