| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1454846-35-5 |
| Catalog No. | 2A-1170249 |
| Chinese Name | 劳拉替尼 |
| Synonyms | UNII:OSP71S83EU; lorlatinib; PF06463922; PF-06463922 |
| Molecular Formula | C21H19FN6O2 |
| Molecular Weight | 406.413 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 675.0±55.0 °C at 760 mmHg |
| Appearance | White to off-white powder |
| Storage Condition | -20℃ |
| Application | Lorlatinib is a potent, dual ALK/ROS1 inhibitor, inhibiting ROS1 with Ki of 0.02 nM, 0.07 nM and 0.7 nM for wild-type ALK and mutant ALK (L1196M), respectively. |
| PubChem ID | 85342763 |
| SMILES | CC1Oc2cc(cnc2N)-c2c(nn(C)c2C#N)CN(C)C(=O)c2ccc(F)cc21 |
| InChI | InChI=1S/C21H19FN6O2/c1-11-15-7-13(22)4-5-14(15)21(29)27(2)10-16-19(17(8-23)28(3)26-16)12-6-18(30-11)20(24)25-9-12/h4-7,9,11H,10H2,1-3H3,(H2,24,25)/t11-/m1/s1 |
| InChI Key | IIXWYSCJSQVBQM-LLVKDONJSA-N |
| Transport Info | Product Name: Lorlatinib |
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