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Home > Products > Pharmaceuticals & Life Science > Pharmaceutical Intermediates > N-((S)-1-(4-((S)-2-(2,4-dichlorophenylsulfonaMido)-3-hydroxypropanoyl)piperazin-1-yl)-4-Methyl-1-oxopentan-2-yl)benzo[b]thiophene-2-carboxaMide
N-((S)-1-(4-((S)-2-(2,4-dichlorophenylsulfonaMido)-3-hydroxypropanoyl)piperazin-1-yl)-4-Methyl-1-oxopentan-2-yl)benzo[b]thiophene-2-carboxaMide structure, CAS 942206-85-1

N-((S)-1-(4-((S)-2-(2,4-dichlorophenylsulfonaMido)-3-hydroxypropanoyl)piperazin-1-yl)-4-Methyl-1-oxopentan-2-yl)benzo[b]thiophene-2-carboxaMide

CAS Number942206-85-1

SynonymsGSK1016790A

Molecular FormulaC28H32Cl2N4O6S2

Molecular Weight655.61300

Purity98.00%

Density

Boiling Point

Melting Point

Flash Point

Appearancepowder

EINECS

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Cat. No.: 2A-1170160 Purity: 98.00%
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Quality Control of [ 942206-85-1 ] Purity: 98.00% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number942206-85-1
Catalog No.2A-1170160
Chinese NameGSK1016790A
SynonymsGSK1016790A
Molecular FormulaC28H32Cl2N4O6S2
Molecular Weight655.61300
Purity98.00
Appearancepowder
Storage Condition-20℃
ApplicationGSK1016790A is a potent transient receptor potential vanilloid 4 (TRPV4) activator.
PubChem ID46491689
SMILESCC(C)CC(NC(=O)c1cc2ccccc2s1)C(=O)N1CCN(C(=O)C(CO)NS(=O)(=O)c2ccc(Cl)cc2Cl)CC1
InChIInChI=1S/C28H32Cl2N4O6S2/c1-17(2)13-21(31-26(36)24-14-18-5-3-4-6-23(18)41-24)27(37)33-9-11-34(12-10-33)28(38)22(16-35)32-42(39,40)25-8-7-19(29)15-20(25)30/h3-8,14-15,17,21-22,32,35H,9-13,16H2,1-2H3,(H,31,36)/t21-,22-/m0/s1
InChI KeyIVYQPSHHYIAUFO-VXKWHMMOSA-N
MSDSmsds/170299_2_942206_85_1.pdf
BioactivityGSK1016790A is a potent transient receptor potential vanilloid 4 (TRPV4) activator. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Cancer References [1]. Jin M et al. Determinants of TRPV4 activity following selective activation by small molecule agonist GSK1016790A. PLoS One, 2011 Feb 14;6(2):e16713. [2]. MP Addison et al. NO synthase inhibition attenuates EDHF-mediated relaxation induced by TRPV4 channel agonist GSK1016790A in the rat pulmonary artery: Role of TxA2. Pharmacol Rep, 2016 Jun, 68(3):620-6. Chemical & Physical Properties Molecular Formula C28H32Cl2N4O6S2 Molecular Weight 655.61300 Exact Mass 654.11400 PSA 176.23000 LogP 5.28510 InChIKey IVYQPSHHYIAUFO-VXKWHMMOSA-N SMILES CC(C)CC(NC(=O)c1cc2ccccc2s1)C(=O)N1CCN(C(=O)C(CO)NS(=O)(=O)c2ccc(Cl)cc2Cl)CC1 Storage condition -20℃
Use ofGSK1016790A is a potent transient receptor potential vanilloid 4 (TRPV4) activator. Properties Name N-[(2S)-1-[4-[(2S)-2-[(2,4-dichlorophenyl)sulfonylamino]-3-hydroxypropanoyl]piperazin-1-yl]-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamide Synonym More Synonyms GSK-1016790A Biological Activity Description GSK1016790A is a potent transient receptor potential vanilloid 4 (TRPV4) activator. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Cancer References [1]. Jin M et al. Determinants of TRPV4 activity following selective activation by small molecule agonist GSK1016790A. PLoS One, 2011 Feb 14;6(2):e16713. Chemical & Physical Properties Exact Mass 654.11400 PSA 176.23000 LogP 5.28510 InChIKey IVYQPSHHYIAUFO-VXKWHMMOSA-N Storage condition -20℃
Transport InfoProduct name: GSK-1016790A
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