CAS Number183133-96-2
SynonymsJevtana; Cabazitaxelum; cabazitaxel; Taxoid XRP6258; TXD258; XRP-6258
Molecular FormulaC45H57NO14
Molecular Weight835.932
Purity98.00%
Density1.3±0.1 g/cm3
Boiling Point870.7±65.0 °C at 760 mmHg
Melting Point180 °C
AppearanceSolid;White to Almost white powder to crystal
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 183133-96-2 |
| Catalog No. | 2A-1169976 |
| Chinese Name | 卡巴他赛 |
| Synonyms | Jevtana; Cabazitaxelum; cabazitaxel; Taxoid XRP6258; TXD258; XRP-6258 |
| Molecular Formula | C45H57NO14 |
| Molecular Weight | 835.932 |
| Purity | 98.00 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 870.7±65.0 °C at 760 mmHg |
| Melting Point | 180 °C |
| Appearance | Solid;White to Almost white powder to crystal |
| Storage Condition | -20°C |
| Application | Cabazitaxel is a semi-synthetic derivative of the natural taxane deacetylbaccatin III, which has significant anti-tumor effects. |
| HTC | 2942000000 |
| PubChem ID | 14816121 |
| SMILES | COC1C(=O)C2(C)C(OC)CC3OCC3(OC(C)=O)C2C(OC(=O)c2ccccc2)C2(O)CC(OC(=O)C(O)C(NC(=O)OC(C)(C)C)c3ccccc3)C(C)=C1C2(C)C |
| InChI | InChI=1S/C45H57NO14/c1-24-28(57-39(51)33(48)32(26-17-13-11-14-18-26)46-40(52)60-41(3,4)5)22-45(53)37(58-38(50)27-19-15-12-16-20-27)35-43(8,36(49)34(55-10)31(24)42(45,6)7)29(54-9)21-30-44(35,23-56-30)59-25(2)47/h11-20,28-30,32-35,37,48,53H,21-23H2,1-10H3,(H,46,52)/t28-,29-,30+,32-,33+,34+,35-,37-,43+,44-,45+/m0/s1 |
| InChI Key | BMQGVNUXMIRLCK-OAGWZNDDSA-N |
| Use of | Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Properties Name cabazitaxel Synonym More Synonyms cabazitaxel Biological Activity Description Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin Research Areas >> Cancer References [1]. Tai X, et al. Cabazitaxel and indocyanine green co-delivery tumor-targeting nanoparticle for improved antitumor efficacy and minimized drug toxicity. J Drug Target. 2016 Sep 9:1-29. [2]. Gdowski AS, et al. Bone-targeted cabazitaxel nanoparticles for metastatic prostate cancer skeletal lesions and pain. Nanomedicine (Lond). 2017 Sep;12(17):2083-2095. Chemical & Physical Properties Molecular Formula C45H57NO14 Exact Mass 835.377930 PSA 202.45000 Index of Refraction 1.592 InChIKey BMQGVNUXMIRLCK-OAGWZNDDSA-N Safety Information Hazard Codes Xi HS Code 2942000000 Precursor & DownStream Precursor 5 CAS#:1380584-07-5 2'-TES-cabazitaxel CAS#:1372883-35-6 2'-THP-cabazitaxel CAS#:1352816-81-9 2'-TBS-cabazitaxel CAS#:32981-86-5 10-Deacetylbacc... DownStream 0 |
| Transport Info | Product Name: Cabazitaxel |
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