CAS Number89365-50-4
Synonyms(+-)-4-hydroxy-alpha1-(((6-(4-phenylbutoxy)hexyl)amino)methyl)-1,3-benzenedi; SAMETEROL; SalmeterolXenofoate; 4-Hydroxy-3-[hydroxymethyl]phenyl-N-[6-phenylbutoxyhexyl]ethanolamine; Salmeterol; 2-(Hydroxymethyl)-4-(1-hydroxy-2-{[6-(4-phenylbutoxy)hexyl]amino}ethyl)phenol; 2-(hydroxymethyl)-4-[1-hydroxy-2-({6-[(4-phenylbutyl)oxy]hexyl}amino)ethyl]phenol; 2-hydroxymethyl-4-{1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl}phenol; (±)-4-Hydroxy-a1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol; MFCD00867037; serevent (R); (±)-4-Hydroxy-a1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-m-xylene-a,a1-diol; 4-HYDROXY-A1-[[[6-(4-PHENYLBUTOXY)HEXYL]AMINO]METHYL]-1,3-BENZENEDIMETHANOL
Molecular FormulaC25H37NO4
Molecular Weight415.566
Purity98%
Density1.1±0.1 g/cm3
Boiling Point603.0±55.0 °C at 760 mmHg
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 89365-50-4 |
| Catalog No. | 2A-1169855 |
| Chinese Name | 沙美特罗 |
| Synonyms | (+-)-4-hydroxy-alpha1-(((6-(4-phenylbutoxy)hexyl)amino)methyl)-1,3-benzenedi; SAMETEROL; SalmeterolXenofoate; 4-Hydroxy-3-[hydroxymethyl]phenyl-N-[6-phenylbutoxyhexyl]ethanolamine; Salmeterol; 2-(Hydroxymethyl)-4-(1-hydroxy-2-{[6-(4-phenylbutoxy)hexyl]amino}ethyl)phenol; 2-(hydroxymethyl)-4-[1-hydroxy-2-({6-[(4-phenylbutyl)oxy]hexyl}amino)ethyl]phenol; 2-hydroxymethyl-4-{1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl}phenol; (±)-4-Hydroxy-a1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol; MFCD00867037; serevent (R); (±)-4-Hydroxy-a1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-m-xylene-a,a1-diol; 4-HYDROXY-A1-[[[6-(4-PHENYLBUTOXY)HEXYL]AMINO]METHYL]-1,3-BENZENEDIMETHANOL |
| Molecular Formula | C25H37NO4 |
| Molecular Weight | 415.566 |
| Purity | 98 |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 603.0±55.0 °C at 760 mmHg |
| Appearance | powder |
| Storage Condition | Refrigerate at 2-8°C |
| Application | Salmeterol is a long-acting β2-adrenoceptor agonist that can be used to treat asthma. |
| HTC | 2922509090 |
| PubChem ID | 9450 |
| SMILES | OCc1cc(C(O)CNCCCCCCOCCCCc2ccccc2)ccc1O |
| InChI | InChI=1S/C25H37NO4/c27-20-23-18-22(13-14-24(23)28)25(29)19-26-15-7-1-2-8-16-30-17-9-6-12-21-10-4-3-5-11-21/h3-5,10-11,13-14,18,25-29H,1-2,6-9,12,15-17,19-20H2 |
| InChI Key | GIIZNNXWQWCKIB-UHFFFAOYSA-N |
| Use of | Salmeterol is a long-acting beta2-adrenergic receptor (beta 2AR) agonist used clinically to treat asthma.Target: beta2-Adrenergic ReceptorSalmeterol is a long-acting beta2-adrenergic receptor agonist drug that is prescribed for the treatment of asthma and chronic obstructive pulmonary disease (COPD). salmeterol also binds with very high affinity at a second site, termed the "exosite", and that this exosite contributes to the long duration of action of salmeterol [1]. Properties Name 2-(hydroxymethyl)-4-(1-hydroxy-2-{[6-(4-phenylbutoxy)hexyl]amino}ethyl)phenol Synonym More Synonyms Salmeterol Biological Activity Description Salmeterol is a long-acting beta2-adrenergic receptor (beta 2AR) agonist used clinically to treat asthma.Target: beta2-Adrenergic ReceptorSalmeterol is a long-acting beta2-adrenergic receptor agonist drug that is prescribed for the treatment of asthma and chronic obstructive pulmonary disease (COPD). salmeterol also binds with very high affinity at a second site, termed the "exosite", and that this exosite contributes to the long duration of action of salmeterol [1]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Others References [1]. Rong, Y., et al., Probing the salmeterol binding site on the beta 2-adrenergic receptor using a novel photoaffinity ligand, [(125)I]iodoazidosalmeterol. Biochemistry, 1999. 38(35): p. 11278-86. Chemical & Physical Properties Molecular Formula C25H37NO4 Exact Mass 415.272247 PSA 81.95000 Index of Refraction 1.566 InChIKey GIIZNNXWQWCKIB-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 1,3-Benzenedimethanol, 4-hydroxy-alpha1-(((6-(4-phenylbutoxy)hexyl)amino)met hyl)-, (+-)- CAS REGISTRY NUMBER : 89365-50-4 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C25-H37-N-O4 MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 5600 ug/kg/28D-I TOXIC EFFECTS : Liver - changes in liver weight Blood - changes in spleen Immunological Including Allergic - decreased immune response REFERENCE : IJIMDS International Journal of Immunopharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1979- Volume(issue)/page/year: 18,523,1996 Safety Information RTECS CZ6457000 HS Code 2922509090 Synthetic Route 2-(Benzyl(6-(4-... 943969-38-8 Salmeterol 89365-50-4 4-Phenylbutan-1... Salmeterol 89365-50-4 Literature: Synthetic Communications, , vol. 29, # 12 p. 2155 - 2162 [4-(6-BROMO-HEX... 94749-73-2 Salmeterol 89365-50-4 Literature: Synthetic Communications, , vol. 29, # 12 p. 2155 - 2162 Precursor & DownStream Precursor 9 CAS#:3360-41-6 4-Phenylbutan-1-ol CAS#:94749-73-2 [4-(6-BROMO-HEX... CAS#:934842-69-0 4-[2-[benzyl-[6... CAS#:629-03-8 1,6-Dibromohexane DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | A. Customs clearance form for inbound goods B. Customs clearance form for outbound goods |
| Inspection | R. Hygiene supervision and inspection of imported food S. Hygiene supervision and inspection of exported food |
| Transport Info | Product name: Supervision conditions A. Customs clearance form for inbound goods B. Customs clearance form for outbound goods |
| Related Products in API & Advanced Intermediates | ||
|---|---|---|
| Saxagliptin hydrochloride | 709031-78-7 | 2A-1169506 |
| Dapagliflozin ((2S)-1,2-propanediol, hydrate) | 960404-48-2 | 2A-1169507 |
| Omeprazole magnesium | 95382-33-5 | 2A-3169785 |
| PANTOPRAZOLE SODIUM SESQUIHYDRATE | 154644-14-1 | 2A-3169786 |
| HYDROCODONE BITARTRATE | 34195-34-1 | 2A-1169854 |
| Cabazitaxel | 183133-96-2 | 2A-1169976 |
| DesosaMinylazithroMycin | 117693-41-1 | 2A-1170147 |
| SALBUTAMOL | 35763-26-9 | 2A-1170210 |
| Dacomitinib | 1110813-31-4 | 2A-1170221 |
| Dehydro Lovastatin | 109273-98-5 | 2A-1170361 |
| Browse all API & Advanced Intermediates products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS