CAS Number565-73-1
SynonymsSodium oxamate; MFCD00044553; sodium,oxamate; Acetic acid, 2-amino-2-oxo-, sodium salt (1:1); Sodium amino(oxo)acetate; Oxalic acid monoamide sodium salt; Acetic acid, aminooxo-, monosodium salt; EINECS 209-290-5; OXAMIC ACID SODIUM SALT
Molecular FormulaC2H2NNaO3
Molecular Weight111.032
Boiling Point306.3ºC at 760 mmHg
Melting Point300 °C
AppearanceWhite crystalline powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 565-73-1 |
| Catalog No. | 2A-1169843 |
| Chinese Name | 草氨酸钠 |
| Synonyms | Sodium oxamate; MFCD00044553; sodium,oxamate; Acetic acid, 2-amino-2-oxo-, sodium salt (1:1); Sodium amino(oxo)acetate; Oxalic acid monoamide sodium salt; Acetic acid, aminooxo-, monosodium salt; EINECS 209-290-5; OXAMIC ACID SODIUM SALT |
| Molecular Formula | C2H2NNaO3 |
| Molecular Weight | 111.032 |
| Boiling Point | 306.3ºC at 760 mmHg |
| Melting Point | 300 °C |
| Appearance | White crystalline powder |
| Storage Condition | Store at RT. |
| Application | Oxalic acid (oxalate) sodium salt is an inhibitor of lactate dehydrogenase a (LDH-a). Sodium oxalate has anti-tumor and anti-proliferative activities on cancer cells and can induce cell apoptosis [1][ |
| HTC | 2924199090 |
| PubChem ID | 3134141 |
| SMILES | NC(=O)C(=O)[O-].[Na+] |
| InChI | InChI=1S/C2H3NO3.Na/c3-1(4)2(5)6;/h(H2,3,4)(H,5,6);/q;+1/p-1 |
| InChI Key | RQVZIJIQDCGIKI-UHFFFAOYSA-M |
| Hazard Symbols | transportation |
| MSDS | msds/169972_2_565_73_1.pdf |
| Bioactivity | Oxamic acid (oxamate) sodium salt is a lactate dehydrogenase-A (LDH-A) inhibitor. Oxamic acid sodium salt shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce apoptosis[1][2][3]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Lactate Dehydrogenase In Vitro Oxamic acid suppresses the proliferation, migration and invasion of both A2780 and SKOV3 cells[1]. Oxamic acid (10 μM; 24-72 h) inhibits cell proliferation in a dose- and time-dependent manner in both NPC cancer cells[2]. Oxamic acid (0-100 mM; 24 h) induces cell cycle arrest in the G2/M phase in CNE-1 and CNE-2 cells[2]. Oxamic acid (0-100 mM; 48 h) induces apoptosis via caspase-3 activation and the mitochondrial pathway in NPC cells[2]. Oxamic acid (0-100 mM; 24 h) increases ROS levels in NPC cells[2]. Cell Proliferation Assay[2] Cell Line: CNE-1 and CNE-2 cells Concentration: 10 μM Incubation Time: 24-72 hours Result: Showed IC50s of 74.6, 32.4 and 17.8 mM and 62.3, 44.5, 31.6 mM at 24, 48 and 72 h in the CNE-1 and CNE-2 cancer cells, respectively. Apoptosis Analysis[2] Cell Line: 0, 20, 50 and 100 mM Concentration: 10 μM Incubation Time: 48 hours Result: Showed the increasement of early and late apoptotic cells in a dose-dependent manner. Increased the expression of pro-apoptotic Bax and cleaved-caspase-3, while reduced the anti-apoptotic signals of Bcl-2 and pro-caspase-3. Cell Cycle Analysis[2] Cell Line: 0, 20, 50 and 100 mM Concentration: 10 μM Incubation Time: 24 hours Result: Showed a dose-dependent increase in the numbers of CNE-1 and CNE-2 cells in the G2/M phase. In Vivo Oxamic acid (intraperitoneal injection; 750 mg/kg; once daily; 3 w) treatment improves the efficacy of tumor inhibition in vivo when combined with irradiation treatment[2]. Animal Model: Female Balb/c nude mice injected with CNE-1 cells[2] Dosage: 750 mg/kg Administration: Intraperitoneal injection; 750 mg/kg; once daily; 3 weeks Result: Inhibited the tumor growth when compared to either oxamate alone or irradiation alone. Chemical & Physical Properties Boiling Point 306.3ºC at 760 mmHg Melting Point 300 °C Molecular Formula C2H2NNaO3 Molecular Weight 111.032 Flash Point 139ºC Exact Mass 110.993240 PSA 83.22000 InChIKey RQVZIJIQDCGIKI-UHFFFAOYSA-M SMILES NC(=O)C(=O)[O-].[Na+] Storage condition Store at RT. |
| Use of | Oxamic acid (oxamate) sodium salt is a lactate dehydrogenase-A (LDH-A) inhibitor. Oxamic acid sodium salt shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce apoptosis[1][2][3]. Properties Articles19 Name oxamic acid sodium salt Synonym More Synonyms Sodium oxamate Biological Activity Description Oxamic acid (oxamate) sodium salt is a lactate dehydrogenase-A (LDH-A) inhibitor. Oxamic acid sodium salt shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce apoptosis[1][2][3]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Lactate Dehydrogenase Chemical & Physical Properties Molecular Formula C2H2NNaO3 Exact Mass 110.993240 PSA 83.22000 InChIKey RQVZIJIQDCGIKI-UHFFFAOYSA-M SMILES NC(=O)C(=O)[O-].[Na+] Storage condition Store at RT. |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| Acid brown 452 | 152521-14-7 | 2A-1169837 |
| butropium bromide | 29025-14-7 | 2A-1169838 |
| baohuoside I | 113558-15-9 | 2A-1169839 |
| DL-lysine hydrochloride | 22834-80-6 | 2A-1169840 |
| Tiagabine hydrochloride | 145821-59-6 | 2A-0202294 |
| 2-METHOXYSTYRENE | 612-15-7 | 2A-1169844 |
| Bitter Melon Extract | 2A-1169846 | 2A-1169846 |
| 2,3-DIHYDRO-1,4-BENZODIOXINE-2-CARBONYL CHLORIDE | 3663-81-8 | 2A-1169847 |
| BIS(PHENYLSULFONYL)SULFIDE | 4388-22-1 | 2A-1169848 |
| 1-PHENYLDECANE | 104-72-3 | 2A-1169849 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS