CAS Number857064-38-1
Synonyms(2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]acrylamide; (E)-3-(6-bromopyridin-2-yl)-2-cyano-N-[(1S)-1-phenylethyl]prop-2-enamide; WP1066
Molecular FormulaC17H14BrN3O
Molecular Weight356.217
Density1.4±0.1 g/cm3
Boiling Point569.9±50.0 °C at 760 mmHg
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 857064-38-1 |
| Catalog No. | 2A-1169365 |
| Chinese Name | (2E)-3-(6-溴-2-吡啶基)-2-氰基-N-[(1S)-1-苯基乙基]-2-丙烯酰胺 |
| Synonyms | (2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]acrylamide; (E)-3-(6-bromopyridin-2-yl)-2-cyano-N-[(1S)-1-phenylethyl]prop-2-enamide; WP1066 |
| Molecular Formula | C17H14BrN3O |
| Molecular Weight | 356.217 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 569.9±50.0 °C at 760 mmHg |
| Storage Condition | room temperature |
| Application | WP1066 is a novel JAK2 and STAT3 inhibitor that also acts on STAT5 and ERK1/2, but has no effect on JAK1 and JAK3. |
| HTC | 2933399090 |
| PubChem ID | 16292933 |
| SMILES | CC(NC(=O)C(C#N)=Cc1cccc(Br)n1)c1ccccc1 |
| InChI | InChI=1S/C17H14BrN3O/c1-12(13-6-3-2-4-7-13)20-17(22)14(11-19)10-15-8-5-9-16(18)21-15/h2-10,12H,1H3,(H,20,22)/b14-10+/t12-/m0/s1 |
| InChI Key | VFUAJMPDXIRPKO-LQELWAHVSA-N |
| Use of | Properties Name (S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide Synonym More Synonyms WP1066 Biological Activity Related Catalog Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK Signaling Pathways >> JAK/STAT Signaling >> STAT Signaling Pathways >> Stem Cell/Wnt >> STAT Research Areas >> Cancer References [1]. Verstovsek S, et al. WP1066, a novel JAK2 inhibitor, suppresses proliferation and induces apoptosis in erythroid human cells carrying the JAK2 V617F mutation. Clin Cancer Res, 2008, (3), 788-796. [2]. Hatiboglu MA, et al. The tumor microenvironment expression of p-STAT3 influences the efficacy of cyclophosphamide with WP1066 in murine melanoma models. Int J Cancer, 2012, 131(1), 8-17 [3]. Ferrajoli A, et al. WP1066 disrupts Janus kinase-2 and induces caspase-dependent apoptosis in acute myelogenous leukemia cells. Cancer Res, 2007, 67(23), 11291-11299. Chemical & Physical Properties Molecular Formula C17H14BrN3O Exact Mass 355.032013 PSA 65.78000 Index of Refraction 1.637 InChIKey VFUAJMPDXIRPKO-LQELWAHVSA-N Safety Information Hazard Codes Xi HS Code 2933399090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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